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  • 1
    Online Resource
    Online Resource
    Application of a Novel Common-Iliac-Artery Skirt Technology (CST) in Treating Challenge Aorto-Iliac or Isolated Iliac Artery Aneurysms
    Frontiers Media SA ; 2021
    In:  Frontiers in Cardiovascular Medicine Vol. 8 ( 2021-10-18)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 8 ( 2021-10-18)
    Abstract: Purpose: To report a novel common-iliac-artery skirt technology (CST) in treating challenge iliac artery aneurysms. Methods: When required healthy landing zone of common iliac artery (CIA) is not available, CST is a strategy to exclude the internal iliac artery (IIA) and prevent IIA reflux without need of embolization. Patients who received endovascular aneurysm repair (EVAR) in our center from 2014 to 2020 were retrospectively screened, and patients treated with CST or with IIA embolization (IIAE) were enrolled. Results: After retrospective screen of 524 EVAR patients, 39 CST patients, 26 IIAE patients, and 7 CST + IIAE patients were enrolled in this study. CST group suggested to have more aged, hyperlipemia, and smoking patients than IIAE group. Two groups had comparable maximal diameter of abdominal aorta (AA), CIA, EIA, but larger diameter of IIA (CST 19.82 ± 2.281 vs. IIAE 27.82 ± 3.401, p = 0.048), and CIA bifurcation (CST 25.01 ± 1.316 vs. IIAE 29.76 ± 2.775, p = 0.087) was found in IIAE group. Anatomy of 79.5% of CST patients and 92.3% of IIAE patients ( p = 0.293) was not suitable for potential use of iliac branch device. CST group had significant shorter surgery time (CST 97.42 ± 3.891 vs. IIAE 141.0 ± 8.010, p & lt; 0.001), shorter hospital stay (CST 15.35 ± 0.873 vs. IIAE 19.32 ± 1.067, p = 0.009), lower in-hospital [CST 0% (0/39) vs. IIAE 11.5% (3/26), p = 0.059] and 1-year follow-up stent related MAEs [CST 6.7% (2/30) vs. IIAE 28.6% (6/21), p = 0.052], but comparable mortality and stent related MAEs for all-cohort follow-up analysis comparing to IIAE group. In our study, a lower in-hospital buttock claudication (BC) rate for CST (CST 20.5% vs. IIAE 46.2%, p = 0.053) and a comparable erectile dysfunction (ED) rate (CST 10.3% vs. IIAE 23.1%, p = 0.352) were found between CST and IIAE groups. After 1 year, both groups had about one third relief of BC symptoms [CST 33.3% (4/12) vs. IIAE 30.7% (4/13), p = 1.000]. Subgroup analysis of 14 patents concomitant with IIA aneurysm in CST group and the 7 CST + IIAE patients were carried out, and no difference was found in mortality, stent MAEs, sac dilation, or reintervention rate. Last, illustration of seven typical CST cases was presented. Conclusion: In selected cases, the CST is a safe, feasible-and-effective choose in treating challenge iliac artery aneurysms and preventing IIA endoleak.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    DOI: 10.3389/fcvm.2021.745250
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2781496-8
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  • 2
    Online Resource
    Online Resource
    Mass cytometry-based peripheral blood analysis as a novel tool for early detection of solid tumours: a multicentre study
    BMJ ; 2023
    In:  Gut Vol. 72, No. 5 ( 2023-05), p. 996-1006
    Details
    In: Gut, BMJ, Vol. 72, No. 5 ( 2023-05), p. 996-1006
    Abstract: Early detection of a tumour remains an unmet medical need, and approaches with high sensitivity and specificity are urgently required. Mass cytometry time-of-flight (CyTOF) is a powerful technique to profile immune cells and could be applied to tumour detection. We attempted to establish diagnostic models for hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC). Design We performed CyTOF analysis for 2348 participants from 15 centres, including 1131 participants with hepatic diseases, 584 participants with pancreatic diseases and 633 healthy volunteers. Diagnostic models were constructed through random forest algorithm and validated in subgroups. Results We determined the disturbance of systemic immunity caused by HCC and PDAC, and calculated a peripheral blood immune score (PBIScore) based on the constructed model. The PBIScore exhibited good performance in detecting HCC and PDAC, with both sensitivity and specificity being around 80% in the validation cohorts. We further established an integrated PBIScore (iPBIScore) by combining PBIScore and alpha-fetoprotein or carbohydrate antigen 19-9. The iPBIScore for HCC had an area under the curve (AUC) of 0.99, 0.97 and 0.96 in training, internal validation and external validation cohorts, respectively. Similarly, the iPBIScore for PDAC showed an AUC of 0.99, 0.98 and 0.97 in the training, internal validation and external validation cohorts, respectively. In early-stage and tumour-marker-negative patients, our iPBIScore-based models also showed an AUC of 0.95–0.96 and 0.81–0.92, respectively. Conclusion Our study proved that the alterations of peripheral immune cell subsets could assist tumour detection, and provide a ready-to-use detection model for HCC and PDAC.
    Type of Medium: Online Resource
    ISSN: 0017-5749 , 1468-3288
    URL: Article
    DOI: 10.1136/gutjnl-2022-327496
    RVK:
    XA 10000
    Language: English
    Publisher: BMJ
    Publication Date: 2023
    detail.hit.zdb_id: 1492637-4
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  • 3
    Online Resource
    Online Resource
    Turbulence‐Driven Magnetic Reconnection in the Magnetosheath Downstream of a Quasi‐Parallel Shock: A Three‐Dimensional Global Hybrid Simulation
    American Geophysical Union (AGU) ; 2020
    In:  Geophysical Research Letters Vol. 47, No. 1 ( 2020-01-16)
    Details
    In: Geophysical Research Letters, American Geophysical Union (AGU), Vol. 47, No. 1 ( 2020-01-16)
    Abstract: We describe the process for the formation of current sheets and occurrence of reconnection in the quasi‐parallel shocked magnetosheath The downstream current sheets are formed after the upstream waves penetrate through the shock and are then compressed The evidences of reconnection in the downstream include the formation of flux ropes and high‐speed flows in the outflow region
    Type of Medium: Online Resource
    ISSN: 0094-8276 , 1944-8007
    URL: Article
    DOI: 10.1029/2019GL085661
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2020
    detail.hit.zdb_id: 2021599-X
    detail.hit.zdb_id: 7403-2
    SSG: 16,13
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  • 4
    Online Resource
    Online Resource
    Aortic arch type, a novel morphological indicator and the risk for acute type B aortic dissection
    Oxford University Press (OUP) ; 2022
    In:  Interactive CardioVascular and Thoracic Surgery Vol. 34, No. 3 ( 2022-02-21), p. 446-452
    Details
    In: Interactive CardioVascular and Thoracic Surgery, Oxford University Press (OUP), Vol. 34, No. 3 ( 2022-02-21), p. 446-452
    Abstract: Aortic arch type is a readily recognizable and obtainable morphological feature of the aorta that does not require complex measurements. The goal of this study was to evaluate whether aortic arch type is a comparable and alternative morphological parameter for predicting acute type B aortic dissection (aTBAD) by comparing the prognostic value of the aortic arch type with that of other morphological parameters such as aortic length, angulation and tortuosity index. METHODS The patients with aTBAD (n = 216) were matched 1:1 with a control group (n = 263) by propensity score matching. The morphological data of the ascending aorta and the aortic arch, which included diameter, length, angulation and tortuosity index, were collected on a three-dimensional aortic model using 3mensio Vascular software. The aortic arch type was identified by the vertical distance from the origin of the brachiocephalic trunk to the top of the arch. The binary logistic regression models were analysed to determine the independent geometric variables related to the aTBAD. The nonparametric approach was performed to assess whether there were statistical differences between the area under the receiver operating characteristic curves (AUC) of the models. RESULTS After propensity score matching, 151 matched pairs of patients were selected. The diameters at the sinotubular junction and the mid-ascending aorta, the ascending aorta length and the ascending aorta angulation in the aTBAD group were significantly greater than those of the controls. Compared with the control group, the diameters at the proximal aortic arch, mid-aortic arch and distal aortic arch, the angulation and the tortuosity index of the aortic arch were significantly greater in the aTBAD group. The proportion of the type III arch in the patients with aTBAD is higher than that of the type I arch and the type II arch (χ2 = 70.187; P  & lt; 0.001). Binary logistic regression analysis showed that the diameter at the mid-aortic arch, the ascending aorta length, the aortic arch angulation and the tortuosity index were independently related to the aTBAD with an AUC value of 0.887. Another binary logistic regression analysis indicated that the diameter at the mid-aortic arch and the aortic arch type were independent correlative variables associated with the aTBAD with an AUC of 0.874. No significant difference was observed in the prognostic value of receiver operating characteristic curves between the 2 models (P = 0.716). CONCLUSIONS The type III arch, which has the characteristics of aortic elongation, incremental angulation and tortuosity index, is a comparable and alternative identifier for patients at high risk for aTBAD.
    Type of Medium: Online Resource
    ISSN: 1569-9285
    URL: Article
    DOI: 10.1093/icvts/ivab359
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 2022
    detail.hit.zdb_id: 2096257-5
    detail.hit.zdb_id: 3167862-2
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  • 5
    Online Resource
    Online Resource
    Three‐Dimensional Global Hybrid Simulations of High Latitude Magnetopause Reconnection and Flux Ropes During the Northward IMF
    American Geophysical Union (AGU) ; 2021
    In:  Geophysical Research Letters Vol. 48, No. 21 ( 2021-11-16)
    Details
    In: Geophysical Research Letters, American Geophysical Union (AGU), Vol. 48, No. 21 ( 2021-11-16)
    Abstract: High latitude magnetopause reconnection with different northward IMF clock angles is studied by using 3‐D global hybrid simulations High latitude magnetopause flux ropes (HLMFRs) with four topologies of magnetic field lines are formed by multiple X‐line reconnection IMF clock angle effects where the HLMFRs occurs and the direction of the HLMFRs' axis
    Type of Medium: Online Resource
    ISSN: 0094-8276 , 1944-8007
    URL: Article
    DOI: 10.1029/2021GL095003
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2021
    detail.hit.zdb_id: 2021599-X
    detail.hit.zdb_id: 7403-2
    SSG: 16,13
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    Online Resource
  • 6
    Online Resource
    Online Resource
    Video_1.MP4
    Frontiers Media SA ; 2022
    In:  Frontiers in Cardiovascular Medicine Vol. 9 ( 2022-6-23)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-6-23)
    Abstract: Abdominopelvic arteriovenous malformation is an uncommon congenital vascular lesion, for which the diagnosis and treatment are usually difficult. Though embolization and sclerotherapy are the primary treatment strategies, traditional surgical resection remains a valuable option. Case Presentation Herein, we present a 32-year-old female diagnosed with a massive abdominopelvic arteriovenous malformation that originates from the splenic artery and drains into the portal vein. The vascular lesion was evaluated with multiple imaging modalities and then surgically resected successfully. The patient was discharged post-operatively on day 6 and free of symptoms during the 12-month follow-up. Conclusion To our knowledge, the presented abdominopelvic arteriovenous malformation is the first to be reported in the literature, with such a rare condition originating from the splenic artery and draining into the portal vein.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    URL: Article
    DOI: 10.3389/fcvm.2022.916096
    DOI: 10.3389/fcvm.2022.916096.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2781496-8
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  • 7
    Online Resource
    Online Resource
    Table_2.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Cardiovascular Medicine Vol. 9 ( 2022-3-15)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-3-15)
    Abstract: The Ankura II Thoracic Stent Graft System (Lifetech, Shenzhen, China) is an evolution of the Ankura stent graft. This study reports one-year outcomes of the Ankura II Thoracic Stent Graft System for endovascular treatment of Stanford type B aortic dissections. Methods The Ankura II Thoracic Aortic Endovascular Trial was a randomized, single-blinded, clinical trial conducted at 12 Chinese institutes. The enrolled patients diagnosed with Stanford type B aortic dissections (TBADs) were randomly assigned to the Ankura group or Ankura II group. Standard follow-up examinations were performed at 1, 6, and 12 months. Safety and efficacy data were analyzed. Results 132 patients with TBADs were enrolled. The outcomes for the primary safety end points revealed that the Ankura II stent graft was statistically non-inferior compared to the Ankura stent graft. The 1-month device-related major adverse events (1.6 vs. 0%; p = 0.48), 1-month all-cause mortality (1.7 vs. 4.5%; p = 0.621), 12-month survival rate (95.2 ± 2.7% vs. 94.1 ± 2.9%; p = 0.769), and major adverse event (MAE) rate (5.1 vs. 4.7% at 1 month; p = 0.73 and 5.8 vs. 8.9% at 12 months; p = 0.718) of Ankura II group are all comparable to Ankura group. The two groups showed similar primary effectiveness and true lumen expansion effect, and false lumen remodeling was improved in Ankura II group (−100.0 vs. −48.5%; p = 0.08). Conclusions The one-year outcomes from this prospective, randomized, multicenter study demonstrate that Ankura II stent graft shows comparable results to Ankura for treating TBADs, resulting in low mortality rates, MAEs and reintervention rates. Clinical Trial Registration ChiCTR-TRC-12002844.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fcvm.2022.805585
    DOI: 10.3389/fcvm.2022.805585.s001
    DOI: 10.3389/fcvm.2022.805585.s002
    DOI: 10.3389/fcvm.2022.805585.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2781496-8
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  • 8
    Online Resource
    Online Resource
    Particle‐in‐Cell Simulations of Characteristics of Rising‐Tone Chorus Waves in the Inner Magnetosphere
    American Geophysical Union (AGU) ; 2020
    In:  Journal of Geophysical Research: Space Physics Vol. 125, No. 7 ( 2020-07)
    Details
    In: Journal of Geophysical Research: Space Physics, American Geophysical Union (AGU), Vol. 125, No. 7 ( 2020-07)
    Abstract: The frequency chirping rate and the duration of the rising‐tone chorus excited near the magnetic equator change due to propagation effect The amplitude, duration and frequency span of the rising‐tone chorus increase with the increasing number density of energetic electrons The frequency chirping rate increases with increasing temperature anisotropy of energetic electrons, while the duration is the opposite
    Type of Medium: Online Resource
    ISSN: 2169-9380 , 2169-9402
    URL: Article
    DOI: 10.1029/2020JA027961
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2020
    detail.hit.zdb_id: 2033040-6
    detail.hit.zdb_id: 161665-1
    detail.hit.zdb_id: 3094181-7
    SSG: 16,13
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  • 9
    Online Resource
    Online Resource
    Anisotropic Electron Distributions and Whistler Waves in a Series of the Flux Transfer Events at the Magnetopause
    American Geophysical Union (AGU) ; 2019
    In:  Journal of Geophysical Research: Space Physics Vol. 124, No. 3 ( 2019-03), p. 1753-1769
    Details
    In: Journal of Geophysical Research: Space Physics, American Geophysical Union (AGU), Vol. 124, No. 3 ( 2019-03), p. 1753-1769
    Abstract: The electron distribution and whistler wave characteristics are significantly different in the core and draping regions of the FTEs The close correlation between the pancake distribution and compression of the localized magnetic field is observed in the trailing part The whistler waves associated with the FTEs are categorized into the lower and upper bands according to the frequency range
    Type of Medium: Online Resource
    ISSN: 2169-9380 , 2169-9402
    URL: Article
    DOI: 10.1029/2018JA026417
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2019
    detail.hit.zdb_id: 2033040-6
    detail.hit.zdb_id: 161665-1
    detail.hit.zdb_id: 3094181-7
    SSG: 16,13
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  • 10
    Online Resource
    Online Resource
    Structure and Coalescence of Magnetopause Flux Ropes and Their Dependence on IMF Clock Angle: Three‐Dimensional Global Hybrid Simulations
    American Geophysical Union (AGU) ; 2021
    In:  Journal of Geophysical Research: Space Physics Vol. 126, No. 2 ( 2021-02)
    Details
    In: Journal of Geophysical Research: Space Physics, American Geophysical Union (AGU), Vol. 126, No. 2 ( 2021-02)
    Abstract: We study the global structures of flux ropes formed by magnetopause reconnection in cases with different southward IMF clock angles When flux ropes enter the cusps, their helical structure collapses, their core field weakens gradually, and their axial length decreases IMF clock angle can affect whether and where flux ropes coalescence occurs
    Type of Medium: Online Resource
    ISSN: 2169-9380 , 2169-9402
    URL: Article
    DOI: 10.1029/2020JA028670
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2021
    detail.hit.zdb_id: 2033040-6
    detail.hit.zdb_id: 161665-1
    detail.hit.zdb_id: 3094181-7
    SSG: 16,13
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