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  • 1
    Online Resource
    Online Resource
    Comparison of intravitreal aflibercept and dexamethasone implant in the treatment of macular edema associated with diabetic retinopathy or retinal vein occlusion: a Meta-analysis and systematic review
    Press of International Journal of Ophthalmology (IJO Press) ; 2022
    In:  International Journal of Ophthalmology Vol. 15, No. 9 ( 2022-9-18), p. 1511-1519
    Details
    In: International Journal of Ophthalmology, Press of International Journal of Ophthalmology (IJO Press), Vol. 15, No. 9 ( 2022-9-18), p. 1511-1519
    Abstract: AIM: To compare the efficacy and safety of intravitreal aflibercept with dexamethasone implant in the treatment of macular edema (ME) associated with diabetic retinopathy (DR) or retinal vein occlusion (RVO). METHODS: A comprehensive search of studies comparing dexamethasone and aflibercept in patients with ME was conducted at PubMed, Embase, and Cochrane Central Register of Controlled Trials from the beginning of library to April 16, 2021. Extracting the data including best-corrected visual acuity (BCVA), central retinal thickness (CRT), number of injections and serious adverse events (SAEs) from the final qualified articles. RevMan 5.3 software was used for Meta-analysis of the included studies. RESULTS: Totally 7 studies with 369 eyes were included. The causes of ME in the final screening study included RVO and DR. Compared with the aflibercept treatment group, the BCVA of the dexamethasone implant treatment group showed no significant difference in the follow-up for 3mo [mean difference (MD): -0.05, 95% confidence interval (CI): -0.11, 0.02; P=0.17] and 12mo (MD: -0.01, 95%CI: -0.38, 0.37; P=0.98), but it was slightly worse than the aflibercept group at 6mo (MD: 0.12, 95%CI: 0.03, 0.21; P=0.008). In terms of CRT reduction, there was no significant difference between the two groups at 3mo (MD: -28.14, 95%CI: -79.95, 23.67; P=0.29), 6mo (MD: 27.67, 95%CI: -84.89, 140.24; P=0.63), and 12mo (MD: -59.00, 95%CI: -127.37,9.37; P=0.09). However, dexamethasone implant had fewer injections, but more adverse events such as elevated intraocular pressure (IOP) and cataract. CONCLUSION: Intravitreal injection of aflibercept and dexamethasone implant can both effectively increase BCVA and reduce CRT. Compared with aflibercept, dexamethasone implant is not inferior in improving vision and reducing CRT in the initial treatment period (3mo) and long-term treatment period (12mo). Besides, it has fewer injections and more likely to cause elevated IOP and cataract.
    Type of Medium: Online Resource
    ISSN: 2222-3959 , 2227-4898
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.18240/ijo.2022.9
    DOI: 10.18240/ijo
    DOI: 10.18240/ijo.2022.09.15
    Language: Unknown
    Publisher: Press of International Journal of Ophthalmology (IJO Press)
    Publication Date: 2022
    detail.hit.zdb_id: 2663246-9
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  • 2
    Online Resource
    Online Resource
    Research on Reliability Evaluation Methods of Distribution System
    Trans Tech Publications, Ltd. ; 2014
    In:  Applied Mechanics and Materials Vol. 672-674 ( 2014-10), p. 1441-1446
    Details
    In: Applied Mechanics and Materials, Trans Tech Publications, Ltd., Vol. 672-674 ( 2014-10), p. 1441-1446
    Abstract: Research on reliability of distribution network has very important meaning and function to ensure the quality of power supply. This paper introduces some basic concepts of reliability in distribution network, including distribution network reliability definition, task and index. The classical reliability evaluation method was reviewed, and focused on specific distribution network, an example analysis was given, and specific reliability evaluation indexes were calculated. Finally, the future development of distribution network reliability evaluation was made a simple prospect.
    Type of Medium: Online Resource
    ISSN: 1662-7482
    URL: Issue
    URL: Article
    DOI: 10.4028/www.scientific.net/AMM.672-674
    DOI: 10.4028/www.scientific.net/AMM.672-674.1441
    Language: Unknown
    Publisher: Trans Tech Publications, Ltd.
    Publication Date: 2014
    detail.hit.zdb_id: 2251882-4
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  • 3
    Online Resource
    Online Resource
    Review of the Relationship between Harmonic and Parallel Capacitor Fault
    Trans Tech Publications, Ltd. ; 2014
    In:  Advanced Materials Research Vol. 1044-1045 ( 2014-10), p. 507-514
    Details
    In: Advanced Materials Research, Trans Tech Publications, Ltd., Vol. 1044-1045 ( 2014-10), p. 507-514
    Abstract: The parallel capacitors are the most important reactive power compensation devices in power system, while the power system harmonic pollution is becoming increasingly serious in recent years, the accident that caused capacitors fault and damage by overload harmonic always happened. Based on this background and summary of the existing research results, thermal effect and performance index of capacitors are introduced, and analyzed the mechanism of interaction between harmonic and capacitor, then the effect and harm of running capacitor under harmonic conditions are elaborated, finally summarized the feasible measures for harmonic suppression and protection of capacitor devices.
    Type of Medium: Online Resource
    ISSN: 1662-8985
    URL: Issue
    URL: Article
    DOI: 10.4028/www.scientific.net/AMR.1044-1045
    DOI: 10.4028/www.scientific.net/AMR.1044-1045.507
    Language: Unknown
    Publisher: Trans Tech Publications, Ltd.
    Publication Date: 2014
    detail.hit.zdb_id: 2265002-7
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  • 4
    Online Resource
    Online Resource
    CNN-GRU-Based intelligent online prediction of screw machine rotation speed for Earth pressure balance shield machine
    IOP Publishing ; 2022
    In:  Engineering Research Express Vol. 4, No. 4 ( 2022-12-01), p. 045021-
    Details
    In: Engineering Research Express, IOP Publishing, Vol. 4, No. 4 ( 2022-12-01), p. 045021-
    Abstract: During shield machine construction, the precise determination of control parameters is particularly important for construction safety. By effectively using construction big data and mining the information in it, accurate construction control parameters with geological adaptability can be obtained in real time. To this end, this study proposes an intelligent online prediction method for screw machine rotation speed of Earth pressure balanced (EPB) shield based on convolutional neural network gated recursive unit (CNN-GRU). Firstly, the construction data is processed with Pearson correlation coefficient, the 10-dimensional data of the current moment is selected as the input variable, and screw machine rotation speed at the next moment is chosen as the output. Next, CNN is used to extract features from the input variables to find a nonlinear relationship between the input and output. Then, in order to construct a complete screw machine rotation speed prediction model, the GRU is used to filter the features to establish a more accurate nonlinear relationship. Finally, the control effect of the method was verified by simulation experiments. The simulation results show that the proposed method can accurately predict the rotation speed of the screw machine online. The traditional control mode in shield tunnel construction can lead to unstable excavation surface due to time lag and inaccuracy. Meanwhile, once the excavation surface is unstable, soil collapse or uplift can lead to construction safety problems, while the the required construction data to the control room at the next moment can be quickly and accurately fed by the online prediction method proposed in this study, thereby effectively avoiding the above construction safety problems and having certain practical application value.
    Type of Medium: Online Resource
    ISSN: 2631-8695
    URL: Article
    DOI: 10.1088/2631-8695/aca1f9
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2022
    detail.hit.zdb_id: 2978952-7
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  • 5
    Online Resource
    Online Resource
    NAPSB as a predictive marker for prognosis and therapy associated with an immuno-hot tumor microenvironment in hepatocellular carcinoma
    Springer Science and Business Media LLC ; 2022
    In:  BMC Gastroenterology Vol. 22, No. 1 ( 2022-08-20)
    Details
    In: BMC Gastroenterology, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-08-20)
    Abstract: Napsin B Aspartic Peptidase, Pseudogene (NAPSB) was associated with CD4 + T cell infiltration in pancreatic ductal adenocarcinoma. However, the biological role of NAPSB in hepatocellular carcinoma (HCC) remains to be determined. Methods The expression of NAPSB in HCC as well as its clinicopathological association were analyzed using data from several public datasets. qRT-PCR was used to verify the relative expression of NAPSB in patients with HCC using the Zhongnan cohort. Kaplan–Meier analyses, and univariate and multivariate Cox regression were conducted to determine the prognosis value of NAPSB on patients with HCC. Then enrichment analyses were performed to identify the possible biological functions of NAPSB. Subsequently, the immunological characteristics of NAPSB in the HCC tumor microenvironment (TME) were demonstrated comprehensively. The role of NAPSB in predicting hot tumors and its impact on immunotherapy and chemotherapy responses was also analyzed by bioinformatics methods. Results NAPSB was downregulated in patients with HCC and high NAPSB expression showed an improved survival outcome. Enrichment analyses showed that NAPSB was related to immune activation. NAPSB was positively correlated with immunomodulators, tumor-infiltrating immune cells, T cell inflamed score and cancer-immunity cycle, and highly expressed in immuno-hot tumors. High expression of NAPSB was sensitive to immunotherapy and chemotherapy, possibly due to its association with pyroptosis, apoptosis and necrosis. Conclusions NAPSB was correlated with an immuno-hot and inflamed TME, and tumor cell death. It can be utilized as a promising predictive marker for prognosis and therapy in HCC.
    Type of Medium: Online Resource
    ISSN: 1471-230X
    URL: Article
    DOI: 10.1186/s12876-022-02475-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041351-8
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  • 6
    Online Resource
    Online Resource
    Tumor microenvironment: The culprit for ovarian cancer metastasis?
    Elsevier BV ; 2016
    In:  Cancer Letters Vol. 377, No. 2 ( 2016-07), p. 174-182
    Details
    In: Cancer Letters, Elsevier BV, Vol. 377, No. 2 ( 2016-07), p. 174-182
    Type of Medium: Online Resource
    ISSN: 0304-3835
    URL: Article
    DOI: 10.1016/j.canlet.2016.04.038
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 195674-7
    detail.hit.zdb_id: 2004212-7
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Nuclear Factor-κB Plays an Essential Role in the Late Phase of Ischemic Preconditioning in Conscious Rabbits
    Ovid Technologies (Wolters Kluwer Health) ; 1999
    In:  Circulation Research Vol. 84, No. 9 ( 1999-05-14), p. 1095-1109
    Details
    In: Circulation Research, Ovid Technologies (Wolters Kluwer Health), Vol. 84, No. 9 ( 1999-05-14), p. 1095-1109
    Abstract: Abstract —Although it is recognized that late preconditioning (PC) results from upregulation of cardioprotective genes, the specific transcription factor(s) that govern this genetic adaptation remains unknown. The aim of this study was to test the hypothesis that the development of late PC is mediated by nuclear factor-κB (NF-κB) and to elucidate the mechanisms that control the activation of NF-κB after an ischemic stimulus in vivo. A total of 152 chronically instrumented, conscious rabbits were used. A sequence of six 4-minute coronary occlusion/4-minute reperfusion cycles, which elicits late PC, induced rapid activation of NF-κB, as evidenced by a marked increase in p65 content (+164%; Western immunoblotting) and NF-κB DNA binding activity (+306%; electrophoretic mobility shift assay) in nuclear extracts isolated 30 minutes after the last reperfusion. These changes were attenuated 2 hours after ischemic PC and resolved by 4 hours. Competition and supershift assays confirmed the specificity of the NF-κB DNA complex signals. The mobility of the NF-κB DNA complex was shifted by anti-p65 and anti-p50 antibodies but not by anti–c-Rel antibodies, indicating that the subunits of NF-κB involved in gene activation after ischemic PC consist of p65-p50 heterodimers. Pretreatment with the NF-κB inhibitor diethyldithiocarbamate (DDTC; 150 mg/kg IP 15 minutes before ischemic PC) completely blocked the nuclear translocation and increased DNA binding activity of NF-κB. The same dose of DDTC completely blocked the cardioprotective effects of late PC against both myocardial stunning and myocardial infarction, indicating that NF-κB activation is essential for the development of this phenomenon in vivo. The ischemic PC-induced activation of NF-κB was also blocked by pretreatment with N ω -nitro- l -arginine (L-NA), a nitric oxide synthase (NOS) inhibitor, N -2-mercaptopropionyl glycine (MPG), a reactive oxygen species (ROS) scavenger, chelerythrine, a protein kinase C (PKC) inhibitor, and lavendustin A, a tyrosine kinase inhibitor (all given at doses previously shown to block late PC), indicating that ischemic PC activates NF-κB via formation of NO and ROS and activation of PKC- and tyrosine kinase–dependent signaling pathways. A subcellular redistribution and increased DNA binding activity of NF-κB quantitatively similar to those induced by ischemic PC could be reproduced pharmacologically by giving the NO donor diethylenetriamine/NO (DETA/NO) (at a dose previously shown to elicit late PC), demonstrating that NO in itself can activate NF-κB in the heart. Taken together, these results provide direct evidence that activation of NF-κB is a critical step in the signal transduction pathway that underlies the development of the late phase of ischemic PC in conscious rabbits. The finding that four different pharmacological manipulations (L-NA, MPG, chelerythrine, and lavendustin A) produced similar inhibition of NF-κB suggests that this transcription factor is a common downstream pathway through which multiple signals elicited by ischemic stress (NO, ROS, PKC, tyrosine kinases) act to induce gene expression. To our knowledge, this is the first demonstration that NO can promote NF-κB activation in the heart, a finding that identifies a new biological function of NO and may have important implications for various pathophysiological conditions in which NO is involved and for nitrate therapy.
    Type of Medium: Online Resource
    ISSN: 0009-7330 , 1524-4571
    URL: Article
    DOI: 10.1161/01.RES.84.9.1095
    RVK:
    XA 10000
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1999
    detail.hit.zdb_id: 1467838-X
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  • 8
    Online Resource
    Online Resource
    Erdafitinib Antagonizes ABCB1-Mediated Multidrug Resistance in Cancer Cells
    Frontiers Media SA ; 2020
    In:  Frontiers in Oncology Vol. 10 ( 2020-6-25)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 10 ( 2020-6-25)
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2020.00955
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2649216-7
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  • 9
    Online Resource
    Online Resource
    DataSheet1.DOCX
    Frontiers Media SA ; 2024
    In:  Frontiers in Pharmacology Vol. 15 ( 2024-5-2)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 15 ( 2024-5-2)
    Abstract: The therapeutic effect of chemotherapy and targeted therapy are known to be limited by drug resistance. Substantial evidence has shown that ATP-binding cassette (ABC) transporters P-gp and BCRP are significant contributors to multidrug resistance (MDR) in cancer cells. In this study, we demonstrated that a clinical-staged ATR inhibitor ceralasertib is susceptible to P-gp and BCRP-mediated MDR. The drug resistant cancer cells were less sensitive to ceralasertib compared to the parental cells. Moreover, ceralasertib resistance can be reversed by inhibiting the drug efflux activity of P-gp and BCRP. Interestingly, ceralasertib was able to downregulate the level of P-gp but not BCRP, suggesting a potential regulation between ATR signaling and P-gp expression. Furthermore, computational docking analysis predicted high affinities between ceralasertib and the drug-binding sites of P-gp and BCRP. In summary, overexpression of P-gp and BCRP are sufficient to confer cancer cells resistance to ceralasertib, underscoring their role as biomarkers for therapeutic efficacy.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    URL: Article
    DOI: 10.3389/fphar.2024.1400699
    DOI: 10.3389/fphar.2024.1400699.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2024
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 10
    Online Resource
    Online Resource
    Increased protein synthesis is necessary for the development of late preconditioning against myocardial stunning
    American Physiological Society ; 1999
    In:  American Journal of Physiology-Heart and Circulatory Physiology Vol. 277, No. 3 ( 1999-09-01), p. H874-H884
    Details
    In: American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society, Vol. 277, No. 3 ( 1999-09-01), p. H874-H884
    Abstract: In phase I of this study, the rate of protein synthesis was measured by the incorporation of [ 3 H]leucine into the protein pool in the heart of conscious rabbits. At 2 h after ischemic preconditioning (PC) with six 4-min occlusion/4-min reperfusion (O/R) cycles ( group II), the [ 3 H]leucine content in the ischemic-reperfused region was increased by 82% compared with that in controls ( group I), indicating increased protein synthesis. This increase was completely abrogated by pretreatment with cycloheximide (CH; group III). In phase II, rabbits underwent six O/R cycles for three consecutive days ( days 1–3). Controls ( group IV) exhibited late PC against myocardial stunning on days 2 and 3. In group V, which received CH 30 min before the 1st O/R cycle on day 1 (same dose as group III), late PC against stunning on day 2 was completely abrogated. In group VI, pretreatment with CH 24 h before the 1st sequence of O/R cycles had no effect on myocardial stunning on day 1, indicating that the absence of late PC on day 2 in group V cannot be ascribed to delayed toxicity of CH. Taken together, these results demonstrate that, in the conscious rabbit, ischemic PC causes a rapid increase in myocardial protein synthesis and that this increased protein synthesis (or at least a fraction of it) is necessary for the development of the protection against myocardial stunning 24 h later. The late phase of ischemic PC is therefore dependent on the formation of new proteins in intact animals.
    Type of Medium: Online Resource
    ISSN: 0363-6135 , 1522-1539
    URL: Article
    DOI: 10.1152/ajpheart.1999.277.3.H874
    RVK:
    WA 15000
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1999
    detail.hit.zdb_id: 1477308-9
    SSG: 12
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