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  • 1
    Online Resource
    Online Resource
    Comparison of intravitreal aflibercept and dexamethasone implant in the treatment of macular edema associated with diabetic retinopathy or retinal vein occlusion: a Meta-analysis and systematic review
    Press of International Journal of Ophthalmology (IJO Press) ; 2022
    In:  International Journal of Ophthalmology Vol. 15, No. 9 ( 2022-9-18), p. 1511-1519
    Details
    In: International Journal of Ophthalmology, Press of International Journal of Ophthalmology (IJO Press), Vol. 15, No. 9 ( 2022-9-18), p. 1511-1519
    Abstract: AIM: To compare the efficacy and safety of intravitreal aflibercept with dexamethasone implant in the treatment of macular edema (ME) associated with diabetic retinopathy (DR) or retinal vein occlusion (RVO). METHODS: A comprehensive search of studies comparing dexamethasone and aflibercept in patients with ME was conducted at PubMed, Embase, and Cochrane Central Register of Controlled Trials from the beginning of library to April 16, 2021. Extracting the data including best-corrected visual acuity (BCVA), central retinal thickness (CRT), number of injections and serious adverse events (SAEs) from the final qualified articles. RevMan 5.3 software was used for Meta-analysis of the included studies. RESULTS: Totally 7 studies with 369 eyes were included. The causes of ME in the final screening study included RVO and DR. Compared with the aflibercept treatment group, the BCVA of the dexamethasone implant treatment group showed no significant difference in the follow-up for 3mo [mean difference (MD): -0.05, 95% confidence interval (CI): -0.11, 0.02; P=0.17] and 12mo (MD: -0.01, 95%CI: -0.38, 0.37; P=0.98), but it was slightly worse than the aflibercept group at 6mo (MD: 0.12, 95%CI: 0.03, 0.21; P=0.008). In terms of CRT reduction, there was no significant difference between the two groups at 3mo (MD: -28.14, 95%CI: -79.95, 23.67; P=0.29), 6mo (MD: 27.67, 95%CI: -84.89, 140.24; P=0.63), and 12mo (MD: -59.00, 95%CI: -127.37,9.37; P=0.09). However, dexamethasone implant had fewer injections, but more adverse events such as elevated intraocular pressure (IOP) and cataract. CONCLUSION: Intravitreal injection of aflibercept and dexamethasone implant can both effectively increase BCVA and reduce CRT. Compared with aflibercept, dexamethasone implant is not inferior in improving vision and reducing CRT in the initial treatment period (3mo) and long-term treatment period (12mo). Besides, it has fewer injections and more likely to cause elevated IOP and cataract.
    Type of Medium: Online Resource
    ISSN: 2222-3959 , 2227-4898
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.18240/ijo.2022.9
    DOI: 10.18240/ijo
    DOI: 10.18240/ijo.2022.09.15
    Language: Unknown
    Publisher: Press of International Journal of Ophthalmology (IJO Press)
    Publication Date: 2022
    detail.hit.zdb_id: 2663246-9
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  • 2
    Online Resource
    Online Resource
    Research on Reliability Evaluation Methods of Distribution System
    Trans Tech Publications, Ltd. ; 2014
    In:  Applied Mechanics and Materials Vol. 672-674 ( 2014-10), p. 1441-1446
    Details
    In: Applied Mechanics and Materials, Trans Tech Publications, Ltd., Vol. 672-674 ( 2014-10), p. 1441-1446
    Abstract: Research on reliability of distribution network has very important meaning and function to ensure the quality of power supply. This paper introduces some basic concepts of reliability in distribution network, including distribution network reliability definition, task and index. The classical reliability evaluation method was reviewed, and focused on specific distribution network, an example analysis was given, and specific reliability evaluation indexes were calculated. Finally, the future development of distribution network reliability evaluation was made a simple prospect.
    Type of Medium: Online Resource
    ISSN: 1662-7482
    URL: Issue
    URL: Article
    DOI: 10.4028/www.scientific.net/AMM.672-674
    DOI: 10.4028/www.scientific.net/AMM.672-674.1441
    Language: Unknown
    Publisher: Trans Tech Publications, Ltd.
    Publication Date: 2014
    detail.hit.zdb_id: 2251882-4
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  • 3
    Online Resource
    Online Resource
    Review of the Relationship between Harmonic and Parallel Capacitor Fault
    Trans Tech Publications, Ltd. ; 2014
    In:  Advanced Materials Research Vol. 1044-1045 ( 2014-10), p. 507-514
    Details
    In: Advanced Materials Research, Trans Tech Publications, Ltd., Vol. 1044-1045 ( 2014-10), p. 507-514
    Abstract: The parallel capacitors are the most important reactive power compensation devices in power system, while the power system harmonic pollution is becoming increasingly serious in recent years, the accident that caused capacitors fault and damage by overload harmonic always happened. Based on this background and summary of the existing research results, thermal effect and performance index of capacitors are introduced, and analyzed the mechanism of interaction between harmonic and capacitor, then the effect and harm of running capacitor under harmonic conditions are elaborated, finally summarized the feasible measures for harmonic suppression and protection of capacitor devices.
    Type of Medium: Online Resource
    ISSN: 1662-8985
    URL: Issue
    URL: Article
    DOI: 10.4028/www.scientific.net/AMR.1044-1045
    DOI: 10.4028/www.scientific.net/AMR.1044-1045.507
    Language: Unknown
    Publisher: Trans Tech Publications, Ltd.
    Publication Date: 2014
    detail.hit.zdb_id: 2265002-7
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  • 4
    Online Resource
    Online Resource
    NAPSB as a predictive marker for prognosis and therapy associated with an immuno-hot tumor microenvironment in hepatocellular carcinoma
    Springer Science and Business Media LLC ; 2022
    In:  BMC Gastroenterology Vol. 22, No. 1 ( 2022-08-20)
    Details
    In: BMC Gastroenterology, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2022-08-20)
    Abstract: Napsin B Aspartic Peptidase, Pseudogene (NAPSB) was associated with CD4 + T cell infiltration in pancreatic ductal adenocarcinoma. However, the biological role of NAPSB in hepatocellular carcinoma (HCC) remains to be determined. Methods The expression of NAPSB in HCC as well as its clinicopathological association were analyzed using data from several public datasets. qRT-PCR was used to verify the relative expression of NAPSB in patients with HCC using the Zhongnan cohort. Kaplan–Meier analyses, and univariate and multivariate Cox regression were conducted to determine the prognosis value of NAPSB on patients with HCC. Then enrichment analyses were performed to identify the possible biological functions of NAPSB. Subsequently, the immunological characteristics of NAPSB in the HCC tumor microenvironment (TME) were demonstrated comprehensively. The role of NAPSB in predicting hot tumors and its impact on immunotherapy and chemotherapy responses was also analyzed by bioinformatics methods. Results NAPSB was downregulated in patients with HCC and high NAPSB expression showed an improved survival outcome. Enrichment analyses showed that NAPSB was related to immune activation. NAPSB was positively correlated with immunomodulators, tumor-infiltrating immune cells, T cell inflamed score and cancer-immunity cycle, and highly expressed in immuno-hot tumors. High expression of NAPSB was sensitive to immunotherapy and chemotherapy, possibly due to its association with pyroptosis, apoptosis and necrosis. Conclusions NAPSB was correlated with an immuno-hot and inflamed TME, and tumor cell death. It can be utilized as a promising predictive marker for prognosis and therapy in HCC.
    Type of Medium: Online Resource
    ISSN: 1471-230X
    URL: Article
    DOI: 10.1186/s12876-022-02475-8
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041351-8
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  • 5
    Online Resource
    Online Resource
    CNN-GRU-Based intelligent online prediction of screw machine rotation speed for Earth pressure balance shield machine
    IOP Publishing ; 2022
    In:  Engineering Research Express Vol. 4, No. 4 ( 2022-12-01), p. 045021-
    Details
    In: Engineering Research Express, IOP Publishing, Vol. 4, No. 4 ( 2022-12-01), p. 045021-
    Abstract: During shield machine construction, the precise determination of control parameters is particularly important for construction safety. By effectively using construction big data and mining the information in it, accurate construction control parameters with geological adaptability can be obtained in real time. To this end, this study proposes an intelligent online prediction method for screw machine rotation speed of Earth pressure balanced (EPB) shield based on convolutional neural network gated recursive unit (CNN-GRU). Firstly, the construction data is processed with Pearson correlation coefficient, the 10-dimensional data of the current moment is selected as the input variable, and screw machine rotation speed at the next moment is chosen as the output. Next, CNN is used to extract features from the input variables to find a nonlinear relationship between the input and output. Then, in order to construct a complete screw machine rotation speed prediction model, the GRU is used to filter the features to establish a more accurate nonlinear relationship. Finally, the control effect of the method was verified by simulation experiments. The simulation results show that the proposed method can accurately predict the rotation speed of the screw machine online. The traditional control mode in shield tunnel construction can lead to unstable excavation surface due to time lag and inaccuracy. Meanwhile, once the excavation surface is unstable, soil collapse or uplift can lead to construction safety problems, while the the required construction data to the control room at the next moment can be quickly and accurately fed by the online prediction method proposed in this study, thereby effectively avoiding the above construction safety problems and having certain practical application value.
    Type of Medium: Online Resource
    ISSN: 2631-8695
    URL: Article
    DOI: 10.1088/2631-8695/aca1f9
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2022
    detail.hit.zdb_id: 2978952-7
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  • 6
    Online Resource
    Online Resource
    Increased protein synthesis is necessary for the development of late preconditioning against myocardial stunning
    American Physiological Society ; 1999
    In:  American Journal of Physiology-Heart and Circulatory Physiology Vol. 277, No. 3 ( 1999-09-01), p. H874-H884
    Details
    In: American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society, Vol. 277, No. 3 ( 1999-09-01), p. H874-H884
    Abstract: In phase I of this study, the rate of protein synthesis was measured by the incorporation of [ 3 H]leucine into the protein pool in the heart of conscious rabbits. At 2 h after ischemic preconditioning (PC) with six 4-min occlusion/4-min reperfusion (O/R) cycles ( group II), the [ 3 H]leucine content in the ischemic-reperfused region was increased by 82% compared with that in controls ( group I), indicating increased protein synthesis. This increase was completely abrogated by pretreatment with cycloheximide (CH; group III). In phase II, rabbits underwent six O/R cycles for three consecutive days ( days 1–3). Controls ( group IV) exhibited late PC against myocardial stunning on days 2 and 3. In group V, which received CH 30 min before the 1st O/R cycle on day 1 (same dose as group III), late PC against stunning on day 2 was completely abrogated. In group VI, pretreatment with CH 24 h before the 1st sequence of O/R cycles had no effect on myocardial stunning on day 1, indicating that the absence of late PC on day 2 in group V cannot be ascribed to delayed toxicity of CH. Taken together, these results demonstrate that, in the conscious rabbit, ischemic PC causes a rapid increase in myocardial protein synthesis and that this increased protein synthesis (or at least a fraction of it) is necessary for the development of the protection against myocardial stunning 24 h later. The late phase of ischemic PC is therefore dependent on the formation of new proteins in intact animals.
    Type of Medium: Online Resource
    ISSN: 0363-6135 , 1522-1539
    URL: Article
    DOI: 10.1152/ajpheart.1999.277.3.H874
    RVK:
    WA 15000
    Language: English
    Publisher: American Physiological Society
    Publication Date: 1999
    detail.hit.zdb_id: 1477308-9
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Biphasic response of cardiac NO synthase isoforms to ischemic preconditioning in conscious rabbits
    American Physiological Society ; 2000
    In:  American Journal of Physiology-Heart and Circulatory Physiology Vol. 279, No. 5 ( 2000-11-01), p. H2360-H2371
    Details
    In: American Journal of Physiology-Heart and Circulatory Physiology, American Physiological Society, Vol. 279, No. 5 ( 2000-11-01), p. H2360-H2371
    Abstract: In conscious rabbits, a sequence of six 4-min coronary occlusion/4-min reperfusion cycles, which elicits late preconditioning (PC), caused rapid activation of calcium-dependent nitric oxide (NO) synthase (NOS) [cNOS; endothelial NOS (eNOS) and/or neuronal NOS (nNOS)], whereas calcium-independent NOS [inducible NOS (iNOS)] activity remained unchanged. The enhanced cNOS activity was associated with increased myocardial levels of NO 2 and/or NO 3 (NO x ). Twenty-four hours after ischemic PC was induced, the opposite pattern was observed, i.e., there was a pronounced increase in cytosolic iNOS activity but no change in cNOS activity. The initial burst of ischemia-induced cNOS activity was not affected by pretreatment with the antioxidant N-2-mercaptopropionyl glycine (MPG), the protein kinase C (PKC) inhibitor chelerythrine, or the tyrosine kinase inhibitor lavendustin A, indicating that it is independent of the generation of oxidant species and the activation of PKC and tyrosine kinases. In contrast, the delayed upregulation of iNOS 24 h after PC was prevented by pretreatment with N ω -nitro-l-arginine, MPG, or chelerythrine before the PC ischemia, indicating that it is triggered by a signaling mechanism that involves the generation of NO, the formation of oxidant species, and the activation of PKC. Taken together, these results demonstrate that, in conscious animals, ischemic PC elicits a biphasic response in cardiac NOS activity, i.e., an immediate activation of cNOS (most likely eNOS) followed 24 h later by a delayed upregulation of iNOS. To our knowledge, this is the first study to directly measure NOS activity after brief myocardial ischemia in vivo. In conjunction with previous functional studies, the data support a distinctive role of NOS isoforms in late PC, with eNOS serving as the trigger on day 1 and iNOS as the mediator on day 2.
    Type of Medium: Online Resource
    ISSN: 0363-6135 , 1522-1539
    URL: Article
    DOI: 10.1152/ajpheart.2000.279.5.H2360
    RVK:
    WA 15000
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2000
    detail.hit.zdb_id: 1477308-9
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema
    Press of International Journal of Ophthalmology (IJO Press) ; 2021
    In:  International Journal of Ophthalmology Vol. 14, No. 12 ( 2021-12-18), p. 1888-1894
    Details
    In: International Journal of Ophthalmology, Press of International Journal of Ophthalmology (IJO Press), Vol. 14, No. 12 ( 2021-12-18), p. 1888-1894
    Abstract: AIM: To quantitatively detect aqueous levels of angiopoietin-like (ANGPTL)3, ANGPTL4, and ANGPTL6 and investigate their correlation with optical coherence tomography angiography (OCTA) findings in patients with diabetic macular edema (DME). METHODS: This cross-sectional study included 23 patients (27 eyes) with type 2 diabetes and 16 control subjects (20 eyes). All patients underwent OCTA imaging and ultra-wide field fundus photography. Diabetic patients were categorized into two groups according to the presence or absence of diabetic retinopathy (DME group, 14 patients, 16 eyes); and non-diabetic retinopathy (NDR) group, 9 patients, 11 eyes, respectively. Aqueous levels of ANGPTL3, ANGPTL4, and ANGPTL6 were assessed using suspension array technology, and foveal-centered 3×3 mm2 OCTA scans were automatically graded to determine the central, inner, and full vessel density (CVD, IVD, FVD); central, inner, and full perfusion density (CPD, IPD, FPD), foveal avascular zone (FAZ) area, FAZ perimeter, and FAZ circularity index (FAZ-CI) on superficial capillary plexuses. Additionally, central subfield thickness (CST), cube volume (CV), and cube average thickness (CAT) were measured in a model of macular cube 512×128. RESULTS: Aqueous ANGPTL3 levels were not significantly different among the three groups (P 〉 0.05). ANGPTL4 levels were significantly higher in the DME group than the control and NDR groups (P 〈 0.0001 and P 〈 0.001), while ANGPTL6 levels were significantly higher in the DME group than the control group (P 〈 0.05). In the whole cohort, the aqueous ANGPTL3 levels correlated negatively with the IVD, FVD, IPD, and FPD, and positively with the CV and CAT. The aqueous ANGPTL4 levels correlated negatively with the CVD, IVD, FVD, CPD, IPD, and FPD, and positively with the FAZ perimeter, CST, CV, and CAT. The aqueous ANGPTL6 levels correlated negatively with the IVD, FVD, IPD, FPD, FAZ-CI and positively with CST, CV, CAT. CONCLUSION: ANGPTL4 and ANGPTL6 may be associated with vascular leakage in DME and may represent good targets for DME therapy. In addition, OCTA metrics may be useful for evaluating macular ischemia in DME.
    Type of Medium: Online Resource
    ISSN: 2222-3959 , 2227-4898
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.18240/ijo.2021.12
    DOI: 10.18240/ijo
    DOI: 10.18240/ijo.2021.12.12
    Language: Unknown
    Publisher: Press of International Journal of Ophthalmology (IJO Press)
    Publication Date: 2021
    detail.hit.zdb_id: 2663246-9
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  • 9
    Online Resource
    Online Resource
    Discovery of Potent Inhibitors against PGlycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2(4-(Pyridin-2-yl)phenoxy)pyridine Analogue
    American Chemical Society (ACS) ; 2020
    In:  Journal of Medicinal Chemistry Vol. 63, No. 10 ( 2020-05-28), p. 5458-5476
    Details
    In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 63, No. 10 ( 2020-05-28), p. 5458-5476
    Type of Medium: Online Resource
    ISSN: 0022-2623 , 1520-4804
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.1021/acs.jmedchem.0c00337
    DOI: 10.1021/acs.jmedchem.0c00337.s001
    DOI: 10.1021/acs.jmedchem.0c00337.s002
    DOI: 10.1021/acs.jmedchem.0c00337.s003
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2020
    detail.hit.zdb_id: 1491411-6
    SSG: 15,3
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  • 10
    Online Resource
    Online Resource
    The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene
    Proceedings of the National Academy of Sciences ; 1999
    In:  Proceedings of the National Academy of Sciences Vol. 96, No. 20 ( 1999-09-28), p. 11507-11512
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 96, No. 20 ( 1999-09-28), p. 11507-11512
    Abstract: The goal of this study was to interrogate the role of inducible NO synthase (iNOS) in the late phase of ischemic preconditioning (PC) in vivo . A total of 321 mice were used. Wild-type mice preconditioned 24 h earlier with six cycles of 4-min coronary occlusion/4-min reperfusion exhibited a significant ( P 〈 0.05) increase in myocardial iNOS protein content, iNOS activity (assessed as calcium-independent l -citrulline formation), and nitrite + nitrate tissue levels. In contrast, endothelial NOS protein content and calcium-dependent NOS activity remained unchanged. No immunoreactive neuronal NOS was detected. When wild-type mice were preconditioned 24 h earlier with six 4-min occlusion/4-min reperfusion cycles, the size of the infarcts produced by a 30-min coronary occlusion followed by 24 h of reperfusion was reduced markedly (by 67%; P 〈 0.05) compared with sham-preconditioned controls, indicating a late PC effect. In contrast, when mice homozygous for a null iNOS allele were preconditioned 24 h earlier with the same protocol, infarct size was not reduced. Disruption of the iNOS gene had no effect on early PC or on infarct size in the absence of PC. These results demonstrate that ( i ) the late phase of ischemic PC is associated with selective up-regulation of iNOS, and ( ii ) targeted disruption of the iNOS gene completely abrogates the infarct-sparing effect of late PC (but not of early PC), providing unequivocal molecular genetic evidence for an obligatory role of iNOS in the cardioprotection afforded by the late phase of ischemic PC. Thus, this study identifies a specific protein that mediates late PC in vivo .
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.96.20.11507
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 1999
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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