In:
Obesity Facts, S. Karger AG, Vol. 15, No. 2 ( 2022), p. 257-270
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Atrial natriuretic peptide plays a potential role in obesity with unclear molecular mechanisms. The objective of this study was to examine the association between its coding gene ( 〈 i 〉 natriuretic peptide A 〈 /i 〉 [ 〈 i 〉 NPPA 〈 /i 〉 ]) methylation and obesity. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Peripheral blood DNA methylation of 〈 i 〉 NPPA 〈 /i 〉 promoter was quantified at baseline by targeted bisulfite sequencing for 2,497 community members (mean aged 53 years, 38% men) in the Gusu cohort. Obesity was repeatedly assessed by body mass index (BMI) and waist circumference (WC) at baseline and follow-up examinations. The cross-sectional, longitudinal, and prospective associations between 〈 i 〉 NPPA 〈 /i 〉 promoter methylation and obesity were examined. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Of the 9 CpG loci assayed, DNA methylation levels at 6 CpGs were significantly lower in participants with central obesity than those without (all 〈 i 〉 p 〈 /i 〉 & #x3c; 0.05 for permutation test). These CpG methylation levels at baseline were also inversely associated with dynamic changes in BMI or WC during follow-up (all 〈 i 〉 p 〈 /i 〉 & #x3c; 0.05 for permutation test). After an average 4 years of follow-up, hypermethylation at the 6 CpGs (CpG2 located at Chr1:11908348, CpG3 located at Chr1:11908299, CpG4 located at Chr1:11908200, CpG5 located at Chr1:11908182, CpG6 located at Chr1:11908178, and CpG8 located at Chr1:11908165) was significantly associated with a lower risk of incident central obesity (all 〈 i 〉 p 〈 /i 〉 & #x3c; 0.05 for permutation test). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Hypomethylation at 〈 i 〉 NPPA 〈 /i 〉 promoter was associated with increased future risk of central obesity in Chinese adults. Aberrant DNA methylation of the 〈 i 〉 NPPA 〈 /i 〉 gene may participate in the mechanisms of central obesity.
Type of Medium:
Online Resource
ISSN:
1662-4025
,
1662-4033
Language:
English
Publisher:
S. Karger AG
Publication Date:
2022
detail.hit.zdb_id:
2455819-9
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