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  • 1
    Online Resource
    Online Resource
    Chip-Scale Plasmonic Sum Frequency Generation
    Institute of Electrical and Electronics Engineers (IEEE) ; 2017
    In:  IEEE Photonics Journal Vol. 9, No. 3 ( 2017-6), p. 1-8
    Details
    In: IEEE Photonics Journal, Institute of Electrical and Electronics Engineers (IEEE), Vol. 9, No. 3 ( 2017-6), p. 1-8
    Type of Medium: Online Resource
    ISSN: 1943-0655
    URL: Article
    DOI: 10.1109/JPHOT.2017.2705061
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017
    detail.hit.zdb_id: 2495610-7
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  • 2
    Online Resource
    Online Resource
    Data_Sheet_1.PDF
    Frontiers Media SA ; 2021
    In:  Frontiers in Cardiovascular Medicine Vol. 8 ( 2021-9-29)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 8 ( 2021-9-29)
    Abstract: Background: Several cardiovascular risk factors have been suggested to be associated with anthracycline-induced cardiotoxicity, but their quantitative effects have not reached a consensus. Methods: We searched PubMed, EMBASE, and Cochrane Library databases for manuscripts published from inception to February 2021, which reported the results of cardiotoxicity due to anthracycline chemotherapy without trastuzumab. Cardiotoxicity defined by any reduction of left ventricular eject fraction (LVEF) to below 50% or a & gt;10% reduction from baseline was defined as the primary endpoint. Odd ratios (OR) with 95% confidence intervals (CI) were calculated using a random-effects model meta-analysis. Results: A total of 7,488 patients receiving anthracycline chemotherapy without trastuzumab were included, who had at least one risk factor at baseline. Hypertension (OR: 1.99; 95% CI: 1.43–2.76), diabetes mellitus (OR: 1.74; 95% CI: 1.11–2.74), and obesity (OR: 1.72; 95% CI: 1.13–2.61) were associated with increased risk of cardiotoxicity. In addition, the relative reduction of global longitudinal strain (GLS) from baseline after anthracycline treatment could significantly improve the detection ability of cardiotoxicity (28.5%, 95% CI: 22.1–35.8% vs. 16.4%, 95% CI: 13.4–19.9%) compared with LVEF. The early detection rate of anthracycline-induced cardiotoxicity (3 months after chemotherapy) by GLS was 30.2% (95% CI: 24.9–36.1%), which is similar with the overall result of GLS. Conclusions: Hypertension, diabetes mellitus, and obesity are associated with increased risk of anthracycline-induced cardiotoxicity, which indicates that corresponding protective strategies should be used during and after anthracycline treatment. The findings of higher detection rate and better early detection ability for cardiotoxicity than LVEF added new proofs for the advantages of GLS in detection of AIC.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    URL: Article
    DOI: 10.3389/fcvm.2021.736854
    DOI: 10.3389/fcvm.2021.736854.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2781496-8
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  • 3
    Online Resource
    Online Resource
    Amphoteric ion exchange membrane synthesized by radiation-induced graft copolymerization of styrene and dimethylaminoethyl methacrylate into PVDF film for vanadium redox flow battery applications
    Elsevier BV ; 2009
    In:  Journal of Membrane Science Vol. 334, No. 1-2 ( 2009-5), p. 9-15
    Details
    In: Journal of Membrane Science, Elsevier BV, Vol. 334, No. 1-2 ( 2009-5), p. 9-15
    Type of Medium: Online Resource
    ISSN: 0376-7388
    URL: Article
    DOI: 10.1016/j.memsci.2009.02.009
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2009
    detail.hit.zdb_id: 1491419-0
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Designing a new process to prepare amphoteric ion exchange membrane with well-distributed grafted chains for vanadium redox flow battery
    Elsevier BV ; 2012
    In:  Journal of Membrane Science Vol. 419-420 ( 2012-11), p. 1-8
    Details
    In: Journal of Membrane Science, Elsevier BV, Vol. 419-420 ( 2012-11), p. 1-8
    Type of Medium: Online Resource
    ISSN: 0376-7388
    URL: Article
    DOI: 10.1016/j.memsci.2012.04.034
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2012
    detail.hit.zdb_id: 1491419-0
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    A combinatorially regulated RNA splicing signature predicts breast cancer EMT states and patient survival
    Cold Spring Harbor Laboratory ; 2020
    In:  RNA Vol. 26, No. 9 ( 2020-09), p. 1257-1267
    Details
    In: RNA, Cold Spring Harbor Laboratory, Vol. 26, No. 9 ( 2020-09), p. 1257-1267
    Abstract: During breast cancer metastasis, the developmental process epithelial–mesenchymal transition (EMT) is abnormally activated. Transcriptional regulatory networks controlling EMT are well-studied; however, alternative RNA splicing also plays a critical regulatory role during this process. A comprehensive understanding of alternative splicing (AS) and the RNA binding proteins (RBPs) that regulate it during EMT and their impact on breast cancer remains largely unknown. In this study, we annotated AS in the breast cancer TCGA data set and identified an AS signature that is capable of distinguishing epithelial and mesenchymal states of the tumors. This AS signature contains 25 AS events, among which nine showed increased exon inclusion and 16 showed exon skipping during EMT. This AS signature accurately assigns the EMT status of cells in the CCLE data set and robustly predicts patient survival. We further developed an effective computational method using bipartite networks to identify RBP-AS networks during EMT. This network analysis revealed the complexity of RBP regulation and nominated previously unknown RBPs that regulate EMT-associated AS events. This study highlights the importance of global AS regulation during EMT in cancer progression and paves the way for further investigation into RNA regulation in EMT and metastasis.
    Type of Medium: Online Resource
    ISSN: 1355-8382 , 1469-9001
    URL: Article
    DOI: 10.1261/rna.074187.119
    Language: English
    Publisher: Cold Spring Harbor Laboratory
    Publication Date: 2020
    detail.hit.zdb_id: 1475737-0
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Thoracic twice-daily radiotherapy and brain metastasis in patients with small cell lung cancer.
    American Society of Clinical Oncology (ASCO) ; 2019
    In:  Journal of Clinical Oncology Vol. 37, No. 15_suppl ( 2019-05-20), p. 8560-8560
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 37, No. 15_suppl ( 2019-05-20), p. 8560-8560
    Abstract: 8560 Background: Although thoracic twice-daily radiotherapy (TDRT) is one of standards of care for small cell lung cancer, its impact on brain metastases remains unknown. This study aimed to compare TDRT with once-daily radiotherapy (ODRT) for the brain metastases rate after prophylactic cranial irradiation in patients with small cell lung cancer. Methods: Consecutive patients received TDRT (45Gy/30f)/ODRT(50-66Gy/25-33f), chemotherapy and prophylactic cranial irradiation were retrieved from eight hospitals’ databases between 2003 and 2016. The endpoints included brain metastases, progression-free survival and overall survival. Brain metastases rate was evaluated using competing risk analysis. A 1:1 propensity score matching approach was used to control confounding between these two groups. Confounding covariates included eight demographic variables and eight treatment related covariates. Results: Of the 778 eligible patients with median age of 55-year (IQR, 48-61), 204 (26.2%) were female. At a median follow-up time of 23.6 months (IQR, 14.2- 38.2), 131 (16.8%) experienced brain metastases. The rates in TDRT were significantly higher than ODRT (3-year, 26.0% vs. 16.9%; HR = 1.55, 95%CI 1.06-2.26, P = 0.03). Of the 338 matched patients (169 in ODRT vs. 169 in TDRT), 60 (17.8%) experienced brain metastases with 3-year rate of 14.9% in ODRT vs 26.0% in TDRT (HR = 1.71, 95%CI 1.02-2.88, P = 0.04). Progression-free survival was similar in both the whole cohort and the matched one. Overall survival in ODRT tended to be significantly longer after matching (median, 47.2 months in ODRT vs. 32.8 months in TDRT; HR = 1.41, 95%CI 0.99-2.01, P = 0.06). When jointly evaluated biologically effective dose (BED), start of any therapy to the end of radiotherapy (SER) and TDRT/ODRT in the multivariable analysis, the impact of ODRT/TDRT on overall survival become more significant (HR = 1.69, 95%CI 1.05-2.71, P = 0.03). Conclusions: Patients with small cell lung cancer who were treated with thoracic TDRT appeared to have higher risk of brain metastases than those with ODRT, which strongly supports the need for further prospective randomized clinical trials, especially in China or other parts of Asia.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2019.37.15_suppl.8560
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2019
    detail.hit.zdb_id: 2005181-5
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  • 7
    Online Resource
    Online Resource
    Fetal Movement Detection by Wearable Accelerometer Duo Based on Machine Learning
    Institute of Electrical and Electronics Engineers (IEEE) ; 2022
    In:  IEEE Sensors Journal Vol. 22, No. 12 ( 2022-6-15), p. 11526-11534
    Details
    In: IEEE Sensors Journal, Institute of Electrical and Electronics Engineers (IEEE), Vol. 22, No. 12 ( 2022-6-15), p. 11526-11534
    Type of Medium: Online Resource
    ISSN: 1530-437X , 1558-1748 , 2379-9153
    URL: Article
    DOI: 10.1109/JSEN.2022.3172451
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2022
    detail.hit.zdb_id: 2052059-1
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  • 8
    Online Resource
    Online Resource
    DreamFace: Progressive Generation of Animatable 3D Faces under Text Guidance
    Association for Computing Machinery (ACM) ; 2023
    In:  ACM Transactions on Graphics Vol. 42, No. 4 ( 2023-08), p. 1-16
    Details
    In: ACM Transactions on Graphics, Association for Computing Machinery (ACM), Vol. 42, No. 4 ( 2023-08), p. 1-16
    Abstract: Emerging Metaverse applications demand accessible, accurate and easy-to-use tools for 3D digital human creations in order to depict different cultures and societies as if in the physical world. Recent large-scale vision-language advances pave the way for novices to conveniently customize 3D content. However, the generated CG-friendly assets still cannot represent the desired facial traits for human characteristics. In this paper, we present Dream-Face, a progressive scheme to generate personalized 3D faces under text guidance. It enables layman users to naturally customize 3D facial assets that are compatible with CG pipelines, with desired shapes, textures and fine-grained animation capabilities. From a text input to describe the facial traits, we first introduce a coarse-to-fine scheme to generate the neutral facial geometry with a unified topology. We employ a selection strategy in the CLIP embedding space to generate coarse geometry, and subsequently optimize both the detailed displacements and normals using Score Distillation Sampling (SDS) from the generic Latent Diffusion Model (LDM). Then, for neutral appearance generation, we introduce a dual-path mechanism, which combines the generic LDM with a novel texture LDM to ensure both the diversity and textural specification in the UV space. We also employ a two-stage optimization to perform SDS in both the latent and image spaces to significantly provide compact priors for fine-grained synthesis. It also enables learning the mapping from the compact latent space into physically-based textures (diffuse albedo, specular intensity, normal maps, etc.). Our generated neutral assets naturally support blendshapes-based facial animations, thanks to the unified geometric topology. We further improve the animation ability with personalized deformation characteristics. To this end, we learn the universal expression prior in a latent space with neutral asset conditioning using the cross-identity hypernetwork, we subsequently train a neural facial tracker from video input space into the pre-trained expression space for personalized fine-grained animation. Extensive qualitative and quantitative experiments validate the effectiveness and generalizability of DreamFace. Notably, DreamFace can generate realistic 3D facial assets with physically-based rendering quality and rich animation ability from video footage, even for fashion icons or exotic characters in cartoons and fiction movies.
    Type of Medium: Online Resource
    ISSN: 0730-0301 , 1557-7368
    URL: Article
    DOI: 10.1145/3592094
    Language: English
    Publisher: Association for Computing Machinery (ACM)
    Publication Date: 2023
    detail.hit.zdb_id: 2006336-2
    detail.hit.zdb_id: 625686-7
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  • 9
    Online Resource
    Online Resource
    Vaccination against coronavirus disease 2019 in patients with pulmonary hypertension: A national prospective cohort study
    Ovid Technologies (Wolters Kluwer Health) ; 2024
    In:  Chinese Medical Journal Vol. 137, No. 6 ( 2024-03-20), p. 669-675
    Details
    In: Chinese Medical Journal, Ovid Technologies (Wolters Kluwer Health), Vol. 137, No. 6 ( 2024-03-20), p. 669-675
    Abstract: Coronavirus disease 2019 (COVID-19) has potential risks for both clinically worsening pulmonary hypertension (PH) and increasing mortality. However, the data regarding the protective role of vaccination in this population are still lacking. This study aimed to assess the safety of approved vaccination for patients with PH. Methods: In this national prospective cohort study, patients diagnosed with PH (World Health Organization [WHO] groups 1 and 4) were enrolled from October 2021 to April 2022. The primary outcome was the composite of PH-related major adverse events. We used an inverse probability weighting (IPW) approach to control for possible confounding factors in the baseline characteristics of patients. Results: In total, 706 patients with PH participated in this study (mean age, 40.3 years; mean duration after diagnosis of PH, 8.2 years). All patients received standardized treatment for PH in accordance with guidelines for the diagnosis and treatment of PH in China. Among them, 278 patients did not receive vaccination, whereas 428 patients completed the vaccination series. None of the participants were infected with COVID-19 during our study period. Overall, 398 patients received inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine, whereas 30 received recombinant protein subunit vaccine. After adjusting for baseline covariates using the IPW approach, the odds of any adverse events due to PH in the vaccinated group did not statistically significantly increase (27/428 [6.3%] vs. 24/278 [8.6%], odds ratio = 0.72, P = 0.302). Approximately half of the vaccinated patients reported at least one post-vaccination side effects, most of which were mild, including pain at the injection site (159/428, 37.1%), fever (11/428, 2.6%), and fatigue (26/428, 6.1%). Conclusions: COVID-19 vaccination did not significantly augment the PH-related major adverse events for patients with WHO groups 1 and 4 PH, although there were some tolerable side effects. A large-scale randomized controlled trial is warranted to confirm this finding. The final approval of the COVID-19 vaccination for patients with PH as a public health strategy is promising.
    Type of Medium: Online Resource
    ISSN: 0366-6999 , 2542-5641
    URL: Article
    DOI: 10.1097/CM9.0000000000002767
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2024
    detail.hit.zdb_id: 2108782-9
    SSG: 6,25
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  • 10
    Online Resource
    Online Resource
    Hard-carbon hybrid Li-ion/metal anode enabled by preferred mesoporous uniform lithium growth mechanism
    Elsevier BV ; 2024
    In:  Journal of Energy Chemistry Vol. 88 ( 2024-01), p. 252-259
    Details
    In: Journal of Energy Chemistry, Elsevier BV, Vol. 88 ( 2024-01), p. 252-259
    Type of Medium: Online Resource
    ISSN: 2095-4956
    URL: Article
    DOI: 10.1016/j.jechem.2023.09.019
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 2714311-9
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