In:
Journal of Digestive Diseases, Wiley, Vol. 16, No. 6 ( 2015-06), p. 327-336
Abstract:
The incidence of proximal gastric carcinoma ( PGC ) is rising worldwide for unknown reasons. Herein we compare the risk factors of early PGC with distal gastric carcinoma ( DGC ) in patients treated at a single tertiary hospital in C hina. Methods Risk factors of 379 consecutive surgically resected early gastric carcinoma ( EGC ) diagnosed according to the 2010 W orld H ealth O rganization criteria were studied by reviewing their medical records and esophagogastroduodenoscopy/biopsy findings and interviewing patients and family members for the patients' history of environmental toxin exposure ( ETE ), dietary habits, family (FCH) and personal cancer history (PCH) and survival. Differences between PGC ( n = 115), DGC ( n = 264) and age‐matched and gender‐matched controls ( n = 225) were compared. Results Proportion of early PGC in all EGC patients was increased significantly ( P 〈 0.05). The independent risk factors for both PGC and DGC identified by multivariate analysis were intake of preserved food and little fruit, and gastric mucosal intestinal metaplasia and atrophy (all P 〈 0.05). Advanced age (odds ratio [ OR ] 9.83, P 〈 0.01), PCH ( OR 5.09, P 〈 0.05), a high body mass index ( 〉 24 kg/m 2 ) ( OR 2.79, P 〈 0.01) and ETE ( OR 2.31, P 〈 0.05) were independent risk factors for PGC, but not male gender, tobacco or alcohol abuse, hiatus hernia, gastroesophageal reflux disease or columnar‐lined esophagus. In contrast, FCH ( OR 2.34, P 〈 0.01) and Helicobacter pylori infection ( OR 2.81, P 〈 0.001) were independent risk factors for DGC . Conclusion Independent risk factors for PGC in Chinese patients differ from those of DGC or esophageal adenocarcinoma, supporting the classification of PGC as a separate gastric carcinoma entity in the Chinese populations.
Type of Medium:
Online Resource
ISSN:
1751-2972
,
1751-2980
DOI:
10.1111/cdd.2015.16.issue-6
DOI:
10.1111/1751-2980.12240
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2317117-0
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