In:
Pakistan Armed Forces Medical Journal, Army Medical College, Vol. 71, No. 1 ( 2021-02-24), p. 122-28
Abstract:
Objective: To determine the efficacy and safety of sofosbuvir-velpatasvir combination therapy in treatment ofchronic hepatitis C genotype 3. Study Design: Prospective cohort study. Place and Duration of Study: Department of Medicine, Combined Military Hospital Lahore, from Mar 2018 toOct 2019. Methodology: Eighty eight consecutive patients, who were ≥18 years of age with chronic hepatitis C as confirmed by polymerase chain reaction were included in the study. Primary end point was sustained virological response at 12 week post-treatment. Patients with any of the following criteria at presentation were excluded from study: aspartate/alanine aminotransferase 〉 10 times the upper limit of normal, total bilirubin twice the upper limit of normal, haemoglobin 〈 8g/dL, platelet count 〈 30,000/uL, albumin 〈 2 g/dL and creatinine clearance of 〈 60 mL/ min. Additional criteria for exclusion included patients who had co-infection with hepatitis B or human immune deficiency virus (HIV), significant cardiac or lung disease, porphyria, liver cirrhosis caused by non-HCV related causes or co-existent hepatocellular carcinoma. Results: Overall sustained virological response was achieved in 82 of 84 patients (97.6%). One of the patients with genotype 3 had detectable HCV RNA at end of treatment, which became undetectable at 12 weeks, post-treatment. 38 /38 (100%) patients without cirrhosis while 41/43 patients (95.3%) with compensated cirrhosis and 3/3 with decompensated cirrhosis achieved sustained virological response. Two (2.3%) patients had on-treatment virological failure. Four patients were lost to follow up. Conclusion: Treatment with sofosbuvir and velpatasvir is effective and well tolerated in patients with chronichepatitis C, genotype 3.
Type of Medium:
Online Resource
ISSN:
2411-8842
,
0030-9648
DOI:
10.51253/pafmj.v71i1.4339
Language:
Unknown
Publisher:
Army Medical College
Publication Date:
2021
detail.hit.zdb_id:
2923742-7
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