In:
Russian Journal of Infection and Immunity, SPb RAACI, Vol. 3, No. 1 ( 2014-07-07), p. 29-36
Abstract:
Abstract. We studied the prevalence of K. pneumoniae and E. coli resistance to extended spectrum cephalosporins and carbapenems, isolated from patients of eight hospitals in St-Petersburg from January to May, 2012. Prevalence of cephalosporin resistant isolates varied in different hospitals: E. coli – from 7,8 to 50%, K. pneumoniae – from 25,4 to 88,4%. Isolates produced extended spectrum beta-lactamases СТХ-М, mainly СТХ-М-1, also СТХ-М-2 and СТХ-М-9. Twenty two carbapenem-resistant K. pneumoniae strains (also resistant to other antimicrobials) were isolated in three hospitals. MALDI-TOF MS showed that carbapenem resistance was caused by carbapenemase. Carbapenemases of all isolates belonged to metallo-β-lactamases according to results of the ROSCO Diagnostica tests. The gene coding production of New Delhi metallo-β-lactamase (blaNDM-1) were detected in all strains. Our data confirmed that the main cephalosporin resistance mechanism of E. coli и K. pneumoniae in Baltic region (including Russia, St-Petersburg) is CTX-M-1 production. For the first time in Russia K. pneumoniae strains producing metallo-β-lactamases NDM-1 were isolated in several hospitals of St-Petersburg.
Type of Medium:
Online Resource
ISSN:
2313-7398
,
2220-7619
DOI:
10.15789/2220-7619-2013-1
DOI:
10.15789/2220-7619-2013-1-29-36
Language:
Unknown
Publisher:
SPb RAACI
Publication Date:
2014
detail.hit.zdb_id:
3046274-5
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