In:
Annals of the New York Academy of Sciences, Wiley, Vol. 1152, No. 1 ( 2009-01), p. 215-224
Abstract:
Ammodytoxin A (AtxA) is a presynaptically neurotoxic secretory phospholipase A 2 from snake venom. The aim of this study was to investigate the mechanism of its cytotoxicity expressed against mouse motoneuronal NSC34 cells. AtxA displayed a potent dose‐ and time‐dependent cytotoxicity that was associated with apoptosis and not necrosis, as revealed by a reduction of mitochondrial membrane potential, activation of caspase‐3, and by the absence of propidium iodide staining. The cytotoxic‐ and apoptosis‐inducing effects of AtxA were specific for the motoneuronal cells; human embryonic kidney (HEK293) and mouse myoblast (C2C12) cells were shown to be resistant to the toxin.
Type of Medium:
Online Resource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1111/nyas.2009.1152.issue-1
DOI:
10.1111/j.1749-6632.2008.03999.x
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
2834079-6
detail.hit.zdb_id:
211003-9
detail.hit.zdb_id:
2071584-5
SSG:
11
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