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  • 1
    Online Resource
    Online Resource
    S. Karger AG ; 2013
    In:  Neuroepidemiology Vol. 40, No. 3 ( 2013), p. 154-159
    In: Neuroepidemiology, S. Karger AG, Vol. 40, No. 3 ( 2013), p. 154-159
    Abstract: Traumatic brain injury (TBI) is a significant public-health concern. To understand the extent of TBI, it is important to assess the prevalence of TBI in the general population. However, the prevalence of TBI in the general population can be difficult to measure because of differing definitions of TBI, differing TBI severity levels, and underreporting of sport-related TBI. Additionally, prevalence reports vary from study to study. In this present study, we used meta-analytic methods to estimate the prevalence of TBI in the adult general population. Across 15 studies, all originating from developed countries, which included 25,134 adults, 12% had a history of TBI. Men had more than twice the odds of having had a TBI than did women, suggesting that male gender is a risk factor for TBI. The adverse behavioral, cognitive and psychiatric effects associated with TBI coupled with the high prevalence of TBI identified in this study indicate that TBI is a considerable public and personal-health problem.
    Type of Medium: Online Resource
    ISSN: 0251-5350 , 1423-0208
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1483032-2
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  • 2
    In: The Laryngoscope, Wiley, Vol. 128, No. 5 ( 2018-05), p. 1075-1082
    Abstract: Consulting of patients with oropharyngeal carcinoma, classified as pT1pN1cM0 and pT2p/cN0cM0, about postoperative radiotherapy is a precarious task as data are lacking. The aim of this study was to evaluate the effects of postoperative radiotherapy for patients with intermediate‐stage oropharyngeal carcinoma. Study Design Multicentric retrospective study. Methods This analysis was conducted at seven Austrian institutions and included data of patients treated between 2000 and 2012. A total of 81 patients with oropharyngeal squamous cell carcinoma were included, of whom 33 patients received postoperative radiotherapy. p16 status determined by immunohistochemistry was available in 68 patients. Results Median follow‐up was 47.9 months. Postoperative radiotherapy showed no benefits in regard to overall survival ( P  = .701). In contrast, disease‐free survival was significantly shortened in all patients without postoperative radiotherapy ( P  = .001). When dividing the cohort in dependence of p16, p16‐positive patients did not benefit from postoperative radiotherapy regarding overall and disease‐free survival ( P  = .934 and P  = .102), whereas p16‐negative patients showed improved disease‐free survival after postoperative radiotherapy ( P  = .007). Multivariate analysis showed that outcome of postoperative radiotherapy is dependent on p16 status. Conclusions In terms of disease‐free survival, patients with p16‐negative tumors may benefit from postoperative radiotherapy, whereas survival of p16‐positive patients is good regardless of additional treatment. Level of Evidence 4. Laryngoscope , 128:1075–1082, 2018
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2026089-1
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