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  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2020
    In:  Orthopaedic Journal of Sports Medicine Vol. 8, No. 3 ( 2020-03-01), p. 232596712091044-
    In: Orthopaedic Journal of Sports Medicine, SAGE Publications, Vol. 8, No. 3 ( 2020-03-01), p. 232596712091044-
    Abstract: Functional outcome scores provide valuable data, yet they can be burdensome to patients and require significant resources to administer. The Knee injury and Osteoarthritis Outcome Score (KOOS) is a knee-specific patient-reported outcome measure (PROM) and is validated for anterior cruciate ligament (ACL) reconstruction outcomes. The KOOS requires 42 questions in 5 subscales. We utilized a machine learning (ML) algorithm to determine whether the number of questions and the resultant burden to complete the survey can be lowered in a subset (activities of daily living; ADL) of KOOS, yet still provide identical data. Hypothesis: Fewer questions than the 17 currently provided are actually needed to predict KOOS ADL subscale scores with high accuracy. Study Design: Cohort study (diagnosis); Level of evidence, 2. Methods: Pre- and postoperative patient-reported KOOS ADL scores were obtained from the Surgical Outcome System (SOS) data registry for patients who had ACL reconstruction. Categorical Boosting (CatBoost) ML models were built to analyze each question and its value in predicting the patient’s actual functional outcome (ie, KOOS ADL score). A streamlined set of minimal essential questions were then identified. Results: The SOS registry contained 6185 patients who underwent ACL reconstruction. A total of 2525 patients between the age of 16 and 50 years had completed KOOS ADL scores presurgically and 3 months postoperatively. The data set consisted of 51.84% male patients and 48.16% female patients, with a mean age of 29 years. The CatBoost model predicted KOOS ADL scores with high accuracy when only 6 questions were asked ( R 2 = 0.95), similar to when all 17 questions of the subscale were asked ( R 2 = 0.99). Conclusion: ML algorithms successfully identified the essential questions in the KOOS ADL questionnaire. Only 35% (6/17) of KOOS ADL questions (descending stairs, ascending stairs, standing, walking on flat surface, putting on socks/stockings, and getting on/off toilet) are needed to predict KOOS ADL scores with high accuracy after ACL reconstruction. ML can be utilized successfully to streamline the burden of patient data collection. This, in turn, can potentially lead to improved patient reporting, increased compliance, and increased utilization of PROMs while still providing quality data.
    Type of Medium: Online Resource
    ISSN: 2325-9671 , 2325-9671
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 2706251-X
    SSG: 31
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  • 2
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Orthopaedic Journal of Sports Medicine Vol. 7, No. 3_suppl ( 2019-03-01), p. 2325967119S0014-
    In: Orthopaedic Journal of Sports Medicine, SAGE Publications, Vol. 7, No. 3_suppl ( 2019-03-01), p. 2325967119S0014-
    Abstract: Knee injury and Osteoarthritis Outcome Score (KOOS) is a widely used patient-reported outcome measurement to track recovery after ACL surgery. This study focuses on the function of daily living subscale (KOOS ADL), which is calculated based on 17 questions. By employing machine learning to predict KOOS ADL scores, we sought to better understand the relative importance of the survey questions and thereby identify its most critical components as well as questions that do not adequately predict outcomes. Methods: Pre- and post-operative patient reported KOOS ADL survey responses and outcomes scores following ACL surgery were obtained from the Surgical Outcome System data registry(SOS), an international patient-reported outcomes database sponsored and maintained by Arthrex. Patients with missing KOOS ADL survey responses were excluded from the study. Machine learning (ML) algorithms such as Random Forest and Gradient Boosting were used to identify the most critical survey questions that predict KOOS ADL scores with high accuracy. These decision tree-based algorithms predict patient outcomes using several decision rules and thereby determining the relative value of individual questions at predicting patient deficits (e.g., if patients have “Severe” difficulty in ascending stairs, they are more likely to have globally worse scores than those with difficulty with other tasks). Results: 4996 patients were initially identified. Based on compliance with the survey, 2407, 2407, 1817 and 1193 patients records for pre-surgery, 3 month, 6 month and 1 year post-surgery responses respectively underwent further analysis. The dataset consisted of 53.9% males and 46.1% females. Mean age was 29 (range 11 to 70 years). Results from the ML models indicated that by 6 key questions, over 80% of the variance in KOOS ADL scores could be explained instead of standard 17 survey questions (Table 1). Interestingly, the analysis provided similar accuracy at both 6 months and 1 year. Discussion and Conclusion: Most patients have similar functional deficits that can be captured using a simplified version of the KOOS ADL survey. The abbreviated survey would result in a better patient reporting experience while still obtaining quality data. Additional work on predicting post-surgery scores using ML from pre-surgery responses and other patient information would provide valuable insights; however, predicting outcome scores with high accuracy remains challenging. We advocate for novel methods to identify and measure meaningful data to assist with understanding patient outcomes and thereby proving the true value of orthopaedic interventions on functional status. [Table: see text]
    Type of Medium: Online Resource
    ISSN: 2325-9671 , 2325-9671
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2706251-X
    SSG: 31
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  • 3
    In: Journal of Clinical Medicine, MDPI AG, Vol. 12, No. 6 ( 2023-03-19), p. 2369-
    Abstract: Machine learning (ML) has not yet been used to identify factors predictive for post-operative functional outcomes following arthroscopic rotator cuff repair (ARCR). We propose a novel algorithm to predict ARCR outcomes using machine learning. This is a retrospective cohort study from a prospectively collected database. Data were collected from the Surgical Outcome System Global Registry (Arthrex, Naples, FL, USA). Pre-operative and 3-month, 6-month, and 12-month post-operative American Shoulder and Elbow Surgeons (ASES) scores were collected and used to develop a ML model. Pre-operative factors including demography, comorbidities, cuff tear, tissue quality, and fixation implants were fed to the ML model. The algorithm then produced an expected post-operative ASES score for each patient. The ML-produced scores were compared to actual scores using standard test-train machine learning principles. Overall, 631 patients who underwent shoulder arthroscopy from January 2011 to March 2020 met inclusion criteria for final analysis. A substantial number of the test dataset predictions using the XGBoost algorithm were within the minimal clinically important difference (MCID) and substantial clinical benefit (SCB) thresholds: 67% of the 12-month post-operative predictions were within MCID, while 84% were within SCB. Pre-operative ASES score, pre-operative pain score, body mass index (BMI), age, and tendon quality were the most important features in predicting patient recovery as identified using Shapley additive explanations (SHAP). In conclusion, the proposed novel machine learning algorithm can use pre-operative factors to predict post-operative ASES scores accurately. This can further supplement pre-operative counselling, planning, and resource allocation. Level of Evidence: III.
    Type of Medium: Online Resource
    ISSN: 2077-0383
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2662592-1
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  • 4
    In: Biomedicines, MDPI AG, Vol. 10, No. 12 ( 2022-12-07), p. 3173-
    Abstract: Producing tremendous amounts of stress and financial burden on the global patient population and healthcare systems around the world, most current modalities of treatment for musculoskeletal ailments often do not address the etiopathogenetic causes of these disorders. Regenerative medicine for musculoskeletal disorders relies on orthobiologics derived from either allogenic or autologous sources. Multiple drawbacks are associated with autologous sources, including donor-site morbidity, a dearth of studies, and variability in both patient reported and clinical/functional outcomes. On the other hand, allogenic sources address several of these concerns, and continue to be a suitable source of mesenchymal stem cells (MSCs). This review qualitatively reports both the preclinical and clinical outcomes of publications studying the applications of umbilical cord (-derived Wharton’s jelly), amniotic suspension allograft, amniotic membrane, and amniotic fluid in musculoskeletal medicine. A systematic review was conducted utilizing the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines on studies published between January 2010 and October 2022 that used allogeneic perinatal tissues. Further randomized controlled clinical studies are necessary to properly evaluate the safety and efficacy of these tissues in orthopedic surgery.
    Type of Medium: Online Resource
    ISSN: 2227-9059
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2720867-9
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  • 5
    Online Resource
    Online Resource
    Elsevier BV ; 2013
    In:  Journal of Orthopaedics Vol. 10, No. 3 ( 2013-9), p. 105-110
    In: Journal of Orthopaedics, Elsevier BV, Vol. 10, No. 3 ( 2013-9), p. 105-110
    Type of Medium: Online Resource
    ISSN: 0972-978X
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2013
    detail.hit.zdb_id: 2240839-3
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  • 6
    Online Resource
    Online Resource
    Frontiers Media SA ; 2023
    In:  Frontiers in Pain Research Vol. 4 ( 2023-6-15)
    In: Frontiers in Pain Research, Frontiers Media SA, Vol. 4 ( 2023-6-15)
    Abstract: Osteoarthritis (OA) induces tremendous amounts of stress and financial burden on patients and healthcare systems worldwide. Current treatments have limitations and do not address the etiopathogenetic cause of OA. Regenerative medicine may circumvent limitations posed by traditional modalities and relies on the utilization of biologics including platelet-rich plasma (PRP). Several peer-reviewed studies have documented the safety and efficacy of autologous PRP in mitigating symptoms in knee and hip OA patients. Nonetheless, only few studies investigated the safety and efficacy of allogenic PRP. This mini review summarizes the outcomes of preclinical and clinical studies using allogenic PRP for treatment of knee or hip OA. We identified 3 preclinical and 1 clinical study using allogenic PRP for treatment of knee OA, and only 1 clinical study using allogenic PRP for treatment of hip OA. Administration of allogenic PRP is safe and probably efficacious in patients with knee or hip OA. However, more pre-clinical studies and high-powered, multi-center, non-randomized and randomized controlled trials with extended follow-up are warranted to further establish the safety and efficacy of allogenic PRP to justify its clinical use.
    Type of Medium: Online Resource
    ISSN: 2673-561X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 3035397-X
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  • 7
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2022
    In:  Journal of Orthopaedic Surgery and Research Vol. 17, No. 1 ( 2022-08-19)
    In: Journal of Orthopaedic Surgery and Research, Springer Science and Business Media LLC, Vol. 17, No. 1 ( 2022-08-19)
    Abstract: The etiology of ischiofemoral impingement (IFI) syndrome, an unusual and uncommon form of hip pain, remains uncertain. Some patients demonstrate narrowing of the space between the ischial tuberosity and lesser trochanter from trauma or abnormal morphology of the quadratus femoris muscle. Combined clinical and imaging aid in the diagnosis. Case report A 32-year-old female presented with a 3 years history of pain over the lower aspect of the right buttock, aggravated by movements of the right hip, and partially relieved with rest and medications. The right hip showed extreme restriction of abduction and external rotation. MRI of the right hip showed reduced ischiofemoral space and quadratus femoris space when compared to the left hip. The patient underwent endoscopic resection of the right lesser trochanter, with no recurrence of pain at 2 years. Conclusion An unusual cause of hip pain, IFI syndrome, should be suspected when hip pain at extremes of movement is associated with signal abnormality of quadratus femoris muscle. Management is tailored to address the inciting factors that precipitated the IFI syndrome.
    Type of Medium: Online Resource
    ISSN: 1749-799X
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2252548-8
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  • 8
    Online Resource
    Online Resource
    Jaypee Brothers Medical Publishing ; 2010
    In:  Strategies in Trauma and Limb Reconstruction Vol. 5, No. 1 ( 2010-04-30), p. 1-10
    In: Strategies in Trauma and Limb Reconstruction, Jaypee Brothers Medical Publishing, Vol. 5, No. 1 ( 2010-04-30), p. 1-10
    Type of Medium: Online Resource
    ISSN: 1828-8936 , 1828-8928
    Language: English
    Publisher: Jaypee Brothers Medical Publishing
    Publication Date: 2010
    detail.hit.zdb_id: 2387508-2
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  • 9
    Online Resource
    Online Resource
    Informa UK Limited ; 2021
    In:  Expert Opinion on Biological Therapy Vol. 21, No. 12 ( 2021-12-02), p. 1551-1560
    In: Expert Opinion on Biological Therapy, Informa UK Limited, Vol. 21, No. 12 ( 2021-12-02), p. 1551-1560
    Type of Medium: Online Resource
    ISSN: 1471-2598 , 1744-7682
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2021
    detail.hit.zdb_id: 2091082-4
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  • 10
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Medicine & Science in Sports & Exercise Vol. 53, No. 8S ( 2021-8), p. 465-465
    In: Medicine & Science in Sports & Exercise, Ovid Technologies (Wolters Kluwer Health), Vol. 53, No. 8S ( 2021-8), p. 465-465
    Type of Medium: Online Resource
    ISSN: 1530-0315 , 0195-9131
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2031167-9
    SSG: 31
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