In:
Acta Crystallographica Section C Structural Chemistry, International Union of Crystallography (IUCr), Vol. 79, No. 8 ( 2023-08-01), p. 316-323
Abstract:
A new zirconium(IV) complex, diaquabis(8-hydroxyquinoline-2-carboxylato-κ 3 N , O 2 , O 8 )zirconium(IV) dimethylformamide disolvate, [Zr(C 10 H 5 NO 3 ) 2 (H 2 O) 2 ]·2C 3 H 7 NO or [Zr(QCa) 2 (H 2 O) 2 ]·2DMF ( 1 ) (HQCaH is 8-hydroxyquinoline-2-carboxylic acid and DMF is dimethylformamide), was prepared and characterized by elemental analysis, IR spectroscopy and single-crystal X-ray structure analysis. Complex 1 is a mononuclear complex in which the Zr IV atoms sit on the twofold axis and they are octacoordinated by two N and six O atoms of two tridentate anionic QCa 2− ligands, and two aqua ligands. Outside the coordination sphere are two DMF molecules bound to the complex unit by hydrogen bonds. The structure and stability of complex 1 in dimethyl sulfoxide were verified by NMR spectroscopy. The cytotoxic properties of 1 and HQCaH were studied in vitro against eight cancer cell lines, and their selectivity was tested on the BJ-5ta noncancerous cell line. Both the complex and HQCaH exhibited low activity, with IC 50 〉 200 µ M . DNA and human serum albumin (HSA) binding studies showed that 1 binds to calf thymus (CT) DNA via intercalation and is able to bind to the tryptophan binding site of HSA (Trp-214).
Type of Medium:
Online Resource
ISSN:
2053-2296
DOI:
10.1107/S2053229623005971
DOI:
10.1107/S2053229623005971/dg3041sup1.cif
DOI:
10.1107/S2053229623005971/dg3041Isup2.hkl
DOI:
10.1107/S2053229623005971/dg3041sup3.pdf
Language:
Unknown
Publisher:
International Union of Crystallography (IUCr)
Publication Date:
2023
detail.hit.zdb_id:
2025703-X
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