In:
Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 31, No. 15_suppl ( 2013-05-20), p. e19159-e19159
Abstract:
e19159 Background: Palliative chemotherapy (CT) can increase survival and quality of life for advanced non-small cell lung cancer (NSCLC) patients (pts). It has been observed in phase III clinical trials that not all pts are able to receive second or further lines of CT. We have analyzed the number of CT lines that pts with advanced NSCLC do in our institution and factors that could have an impact on it. Methods: All pts treated during 2010 for advanced NSCLC in our institution were analyzed (n=124). Quantitative data were compared by Student’s t test. Overall survival (OS) was estimated by Kaplan-Meier analysis and differences were assessed with the log-rank test. Results: Most pts (75.8%) were men. Median age was 66 years. The 67.7% of patients received up to 2 lines of CT, 38.7% 3 lines, 15.3% 4 lines, 8% 5 lines, and 2.4% received up to 6 lines. The higher the number of lines of CT were administered, the higher the median of OS obtained from one line of CT to up to six lines respectively (4.4 vs 10.9 vs 15.6 vs 19.2 vs 31.1 vs 54.3 months, p 〈 0.0001). Women presented a higher median of OS than men (18.7 vs 12.1 months, p=0.015), but without a significant higher number of CT lines (2.6 vs 2.17, p=0.159). Adenocarcinoma pts (54.0%) received greater numbers of CT lines than squamous cell carcinoma pts (26.6%) (2.54 vs 1.58, p=0.007), with a trend towards significant increase in the median OS (14.7 vs 11.6 months, p=0.072). Pts receiving cisplatin-based CT as first line (40.3%) received more lines of treatment than carboplatin-based (46.0%) (2.88 vs 2.04, p=0.001) and were also younger (59.6 vs 65.8 years, p=0.003), but these differences did not have a statistically significant impact on median OS (14.0 vs 11.6 months, p=0.375). Conclusions: In our series, pts with adenocarcinoma histology and cisplatin-based first line treatment received a higher number of lines of CT. Women had better median OS. The number of lines of CT received may have an impact on median OS.
Type of Medium:
Online Resource
ISSN:
0732-183X
,
1527-7755
DOI:
10.1200/jco.2013.31.15_suppl.e19159
Language:
English
Publisher:
American Society of Clinical Oncology (ASCO)
Publication Date:
2013
detail.hit.zdb_id:
2005181-5
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