In:
Medical Principles and Practice, S. Karger AG, Vol. 21, No. 3 ( 2012), p. 228-233
Abstract:
〈 i 〉 Objective: 〈 /i 〉 The aim of this study was to determine the distribution of major risk factors among patients with atherosclerotic disease aged ≤50 years. 〈 i 〉 Subjects and Methods: 〈 /i 〉 The study population comprised 944 patients aged ≤50 years with clinically significant manifestations of atherosclerotic disease compared with 350 consecutive (control) older patients (age 〉 50 years). 〈 i 〉 Results: 〈 /i 〉 The most significant risk factors for atherosclerotic disease of the supra-aortic branches were: smoking (87.5%, p 〈 0.001), family history of atherosclerosis (52.3%, p 〈 0.001), diabetes mellitus (28.5%) and being male (56.9%) (p 〈 0.05 for both). In patients with coronary artery disease, there was considerable disparity in the prevalence of smoking (85.4%), hyperlipoproteinemia (67.4%), and family history of atherosclerosis (68%) (p 〈 0.001). For peripheral artery disease, the most significant risk factors were smoking (97%, p 〈 0.001), hyperlipidemia (p 〈 0.01), and family history of atherosclerotic disease (p 〈 0.01). When compared to controls, patients with premature atherosclerosis smoked more frequently, had hyperlipidemia, had a family history of atherosclerosis, and were more frequently of male sex. 〈 i 〉 Conclusion: 〈 /i 〉 Premature atherosclerosis was most frequently associated with smoking, hyperlipidemia, family history of atherosclerotic disease, and male sex.
Type of Medium:
Online Resource
ISSN:
1011-7571
,
1423-0151
Language:
English
Publisher:
S. Karger AG
Publication Date:
2012
detail.hit.zdb_id:
1482963-0
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