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  • 1
    Online Resource
    Online Resource
    Magnetic Resonance Imaging Assessment of Bone Regeneration in Osseous Defects Filled with Different Biomaterials. An experimental in vivo study
    Revista de Chimie SRL ; 2019
    In:  Materiale Plastice Vol. 56, No. 1 ( 2019-3-30), p. 235-238
    Details
    In: Materiale Plastice, Revista de Chimie SRL, Vol. 56, No. 1 ( 2019-3-30), p. 235-238
    Abstract: Noninvasive techniques, such as Magnetic Resonance Imaging (MRI) are becoming more used in the study of bone regeneration outcomes, in both animal models and human patients. Many studies have shown the potential of tissue engineering therapies to promote healing of skeletal injuries, but further research is needed to optimize these treatment options. This investigation is a continuation of other previous published studies, in which critical-sized bone defects created in the parietal bones of Wistar rats were filled with either bioglass or a biologic collagen scaffold seeded both with adipose-derived mesenchymal stem cells. The present study aims to present the applications of MRI in the assessment of the bone regeneration process in these previously created defects, at specific time intervals. MRI techniques are based on the differences between the spin-latice T1 and spin-spin T2 relaxation times of examined specimens or areas, compared to normal tissues. We measured the relaxation times specific to calvarial specimens with a Brukner Minispec. The results showed that the most favorable results were observed when a collagen scaffold seeded with stem cells was used. MRI enabled the detection of hard and even soft tissue changes, these findings suggesting that MRI could be an effective imaging modality for assessing changes in bone morphology and pathobiology. Furthermore, it can be used as an alternative to Computed Tomography in examining the role of various biomaterials used in bone healing, especially when ionizing radiation is contraindicated.
    Type of Medium: Online Resource
    ISSN: 0025-5289 , 2668-8220
    URL: Article
    DOI: 10.37358/MP.19.1.5158
    Language: English
    Publisher: Revista de Chimie SRL
    Publication Date: 2019
    detail.hit.zdb_id: 2487166-7
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  • 2
    Online Resource
    Online Resource
    Post-Marketing Surveillance of Statins—A Descriptive Analysis of Psychiatric Adverse Reactions in EudraVigilance
    MDPI AG ; 2022
    In:  Pharmaceuticals Vol. 15, No. 12 ( 2022-12-10), p. 1536-
    Details
    In: Pharmaceuticals, MDPI AG, Vol. 15, No. 12 ( 2022-12-10), p. 1536-
    Abstract: Statins are included in the category of high-frequency prescription drugs, and their use is on an upward trend worldwide. In 2012, the FDA issued a warning about possible cognitive adverse drug reactions (ADRs) related to statins, some of which are listed in the Summary of Product Characteristics, but there are still concerns about their potential risk of psychiatric events. The aim of this research was to investigate spontaneous reports containing psychiatric ADRs associated with statins by analyzing the EudraVigilance (EV) database. From January 2004 to July 2021, a total of 8965 ADRs were reported for the Systems Organ Class (SOC) “psychiatric disorders”, of which 88.64% were registered for atorvastatin (3659), simvastatin (2326) and rosuvastatin (1962). Out of a total of 7947 individual case safety reports (ICSRs) of the 3 statins mentioned above, in 36.3% (2885) of them, statins were considered the only suspected drug, and in 42% (3338), no other co-administered drugs were mentioned. Moreover, insomnia has been reported in 19.3% (1536) of cases, being the most frequent adverse reaction. A disproportionality analysis of psychiatric ADRs was performed. The Reporting Odds Ratio (ROR) and 95% confidence interval (95% CI) were calculated for simvastatin, atorvastatin and rosuvastatin compared with antiplatelets and antihypertensive drugs. The reporting probability for most ADRs of these statins compared to antiplatelets was higher. The reporting probability for insomnia, nightmares and depression produced by statins compared to antihypertensive drugs was also higher. The results of this analysis augment the existing data about a possible correlation between the administration of statins and the occurrence of psychiatric side effects.
    Type of Medium: Online Resource
    ISSN: 1424-8247
    URL: Article
    DOI: 10.3390/ph15121536
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2193542-7
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Fatal Association of Mirror and Eisenmenger Syndrome during the COVID-19 Pandemic
    MDPI AG ; 2021
    In:  Medicina Vol. 57, No. 10 ( 2021-09-28), p. 1031-
    Details
    In: Medicina, MDPI AG, Vol. 57, No. 10 ( 2021-09-28), p. 1031-
    Abstract: Mirror syndrome (MS) or Ballantyne’s syndrome is a rare maternal condition that can be life-threatening for both mother and fetus. The condition is characterized by maternal signs and symptoms similar to those seen in preeclampsia in the setting of fetal hydrops. Despite recent advances in the field of maternal-fetal medicine, the etiopathogenesis of MS remains elusive. For patients and doctors, the COVID-19 pandemic has become an extra hurdle to overcome. The following case illustrates how patients’ non-compliance associated with mirror syndrome and SARS-CoV-2 infection led to the tragic end of a 19-year-old patient. Therefore, knowledge of the signs and symptoms of mirror syndrome should always be part of the armamentarium of every obstetrician.
    Type of Medium: Online Resource
    ISSN: 1648-9144
    URL: Article
    DOI: 10.3390/medicina57101031
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2088820-X
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  • 4
    Online Resource
    Online Resource
    The Impact of Living Arrangements on the Prevalence of Falls after Total Joint Arthroplasty: A Comparison between Institutionalized and General Geriatric Population
    MDPI AG ; 2023
    In:  International Journal of Environmental Research and Public Health Vol. 20, No. 4 ( 2023-02-15), p. 3409-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 20, No. 4 ( 2023-02-15), p. 3409-
    Abstract: Due to population aging, there is an increasing need for orthopedic surgery, especially total knee arthroplasty (TKA) and total hip arthroplasty (THA). In geriatric patients, postoperative falls are common events which can compromise the success of these expensive procedures. The aim of our study was to assess the influence of living arrangements on the prevalence of postoperative falls following joint replacement. We included 441 patients after TKA or THA, living in nursing homes, alone or with family. The prevalence of falls in the first 2 years (15.2%) was significantly influenced by living arrangements: patients with TKA or THA living alone had three times higher odds of falling compared to those living with family, and institutionalized patients with THA had four times higher odds of falling compared to those living with family. Of 67 patients who fell, 6 (8.9%) needed reintervention. For TKA patients, the fall rates were not significantly different between institutions and family, indicating the interest of nursing homes in offering proper care. However, for the THA group, the results were poorer, emphasizing the need for improvement in postoperative rehabilitation. Further multi-centric studies are required for generalizing the impact of living arrangements on fall prevalence after joint replacement.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph20043409
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2175195-X
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  • 5
    Online Resource
    Online Resource
    Prevalence of the fabella and its association with pain in the posterolateral corner of the knee : A cross-sectional study in a Romanian population
    Ovid Technologies (Wolters Kluwer Health) ; 2018
    In:  Medicine Vol. 97, No. 47 ( 2018-11), p. e13333-
    Details
    In: Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 97, No. 47 ( 2018-11), p. e13333-
    Abstract: The functions and clinical consequences of the fabella, a sesamoid bone found in the posterolateral aspect of the knee joint, are still a reason of intense debate in the scientific literature. Its incidence was reported to range between 20% and 87% and its presence was usually associated with the persistent pain in the posterolateral region of the knee. The aim of our study was to measure the prevalence, anatomic and clinical features of the fabella within a cross-sectional study, conducted in a Romanian orthopaedic center. Between 2015 and 2017, a consecutive series of 562 patients with knee injuries or persistent knee pain has been examined by radiographs and Magnetic Resonance Imaging and a set of anatomical and clinical parameters have been recorded. Collected data was evaluated with RadiANT DICOM Viewer and statistically analyzed with GraphPad Prism 7. The level of significance was set at P   〈 .05. The incidence of the fabella in our study group was 16.93%, lower than previously reported for Caucasian populations. We found statistically significant differences regarding the possible association of the fabella with pain in the posterolateral corner of the knee ( P  = .04) and the 2 dimensions of the bone according to gender ( P  = .03 respectively P  = .01), but the prevalence was not influenced by gender ( P  = .6). The anatomic characteristics could be important in differentiating this sesamoid bone from calcifications or loose bodies located in the knee joint region. Due to the high association with the posterolateral knee pain, the fabella should be recorded during knee examination as a differential diagnosis, before any surgical procedure.
    Type of Medium: Online Resource
    ISSN: 0025-7974 , 1536-5964
    URL: Article
    DOI: 10.1097/MD.0000000000013333
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2018
    detail.hit.zdb_id: 2049818-4
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  • 6
    Online Resource
    Online Resource
    In vivo Evaluation of a Collagen Scaffold Preconditioned with Adipose-derived Mesenchymal Stem Cells Used for Bone Regeneration A histological study
    Revista de Chimie SRL ; 2018
    In:  Materiale Plastice Vol. 55, No. 4 ( 2018-12-30), p. 691-695
    Details
    In: Materiale Plastice, Revista de Chimie SRL, Vol. 55, No. 4 ( 2018-12-30), p. 691-695
    Abstract: The use of collagen scaffolds and stem cells for obtaining a tissue-engineering complex has been an important concept in promoting repair and regeneration of the bone tissue. Such units represent important steps in the development of an ideal scaffold-cell complex that would sustain new bone apposition. The aim of our study was to perform a histologic evaluation of the healing of critical-sized bone defects, using a biologic collagen scaffold with adipose-derived mesenchymal stem cells, in comparison to negative controls created in the adjacent bone. We used 16 Wistar rats and according to the study design 2 calvarial bone defects were created in each animal, one was filled with collagen seeded with adipose-derived stem cells and the other one was considered negative control. During the following month, at weekly intervals, the animals were euthanized and the specimens from bone defects were histologically evaluated. The results showed that these scaffolds were highly biocompatible as only moderate inflammation no rejection reactions were observed. Furthermore, the first signs of osseous healing appeared after two weeks accompanied by angiogenesis. Collagen scaffolds seeded with adipose-derived mesenchymal stem cells can be considered a promising treatment option in bone regeneration of large defects.
    Type of Medium: Online Resource
    ISSN: 0025-5289 , 2668-8220
    URL: Article
    DOI: 10.37358/MP.18.4.5102
    Language: English
    Publisher: Revista de Chimie SRL
    Publication Date: 2018
    detail.hit.zdb_id: 2487166-7
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  • 7
    Online Resource
    Online Resource
    The occurrence of mycotoxins in wheat from western Romania and histopathological impact as effect of feed intake
    Springer Science and Business Media LLC ; 2013
    In:  Chemistry Central Journal Vol. 7, No. 1 ( 2013-12)
    Details
    In: Chemistry Central Journal, Springer Science and Business Media LLC, Vol. 7, No. 1 ( 2013-12)
    Abstract: The goal of this study has been to evaluate the extent of mycotoxins contamination and their co-occurrence in wheat grain intended for animal feed. A total of 52 wheat samples were collected from the harvest of two consecutive years (2010, 2011) from two counties (Timis and Arad) located in Western Romania and the presence of ochratoxin A (OTA), deoxynivalenol (DON), zearalenone (ZON) and fumonisins (FUMO) was determined by enzyme-linked immunosorbent assay (ELISA). In order to evaluate the toxicological impact of mycotoxins, naturally contaminated wheat samples were administered in rats feed for one month. Results The mycotoxin with the highest incidence in wheat samples was DON due to agro-climatic conditions typical for the west part of Romania. DON was found in 73.08% of samples harvested in 2010 and the highest level of contamination was 3390 ppb. The incidence of DON in sample from 2011 was lower than those of 2010, with a frequency of occurrence of 19.23%. The occurrence of ZON was in the range 69.23–76.92%, with an average value of 187.74 ppb. The OTA content in wheat was below the maximum tolerable limit established by EU Commission regulation for feed legislation (250 ppb). For FUMO the lowest percentage of positive samples was registered (15.38% in wheat sample harvested in 2010 and 11.54% positive samples in 2011). With respect to the co-occurrence of Fusarium mycotoxins, the results proved that ZON was found as a co-contaminant together with DON, especially when climatic conditions for development of fungus are favorable (high air humidity). The differences recorded between investigated localities and their classifications according to the mycotoxin kind and year of harvest were carried out by principal components analysis (PCA). The histopathological and immunohistochemical evaluation performed by hematoxylin and eosin (HE) staining technique as well as by assessing the vascular endothelial growth factor (VEGF) revealed significant modification of kidney, liver and spleen cells in the case of DON and FUMO. In terms of toxicity induced by OTA and ZON it was highlighted mixed normal and necrotic areas in liver, while histological assessment revealed normal VEGF expression in kidneys. Conclusions Although none of the analyzed samples exceeding the stipulated maximum limits for cereals used as feed, a high incidence of mycotoxins produced by Fusarium species have been recorded (DON and ZON) in wheat samples harvested in Western Romania. Also, histopathological evaluation revealed significant tissue lesions in liver and kidney of rats after one month of feeding with natural contaminated wheat.
    Type of Medium: Online Resource
    ISSN: 1752-153X
    URL: Article
    DOI: 10.1186/1752-153X-7-99
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2013
    detail.hit.zdb_id: 2965009-4
    detail.hit.zdb_id: 2272440-0
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  • 8
    Online Resource
    Online Resource
    An evaluation of clove (Eugenia caryophyllata) essential oil as a potential alternative antifungal wood protection system for cultural heritage conservation
    SciELO Agencia Nacional de Investigacion y Desarrollo (ANID) ; 2021
    In:  Maderas. Ciencia y tecnología Vol. 24 ( 2021-12)
    Details
    In: Maderas. Ciencia y tecnología, SciELO Agencia Nacional de Investigacion y Desarrollo (ANID), Vol. 24 ( 2021-12)
    Type of Medium: Online Resource
    ISSN: 0718-221X
    URL: Article
    DOI: 10.4067/S0718-221X2022000100411
    Language: English
    Publisher: SciELO Agencia Nacional de Investigacion y Desarrollo (ANID)
    Publication Date: 2021
    detail.hit.zdb_id: 2201925-X
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  • 9
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    Online Resource
    Combined testing approach to evaluate the antifungal efficiency of clove (Eugenia caryophyllata) essential oil for potential application in wood conservation
    BioResources ; 2020
    In:  BioResources Vol. 15, No. 4 ( 2020-10-27), p. 9474-9489
    Details
    In: BioResources, BioResources, Vol. 15, No. 4 ( 2020-10-27), p. 9474-9489
    Abstract: The efficiency of clove (Eugenia caryophyllata) essential oil (C-EO) for the curative antifungal treatment of historic wood was investigated in comparison with two classical biocide products: a boron-based preservative (Diffusit S) and a formulation containing quaternary ammonium salts and isothiazole (Biotin T). A combined approach was adopted that consisted of implementation of C-EO in a practical case study on a degraded beech (Fagus sylvatica) wood artifact and evaluation of the treatment efficacy via an original laboratory mycological test. Small samples, extracted from the degraded wood material before and after curative treatments, were placed as inoculum on sterile culture medium and incubated for periodic monitoring of the emerging fungal growth for 140 d. Direct observation was supplemented with digital quantification of the fungal coverage area via ImageJ software and calculation of the absolute and relative indices of fungal development reduction. The results indicated that the C-EO solutions at both tested concentrations (10%, 5%) were more efficient than the considered reference products at similar concentrations (Diffusit S (10%) and Biotin T (5%)) for curative antifungal treatment. However, none of the treatments applied entirely prevented reactivation of the severe and complex fungal attack, which was highlighted by the mycological tests conducted on the control samples.
    Type of Medium: Online Resource
    ISSN: 1930-2126 , 1930-2126
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.15376/biores.15.4
    DOI: 10.15376/biores
    DOI: 10.15376/biores.15.4.9474-9489
    Language: English
    Publisher: BioResources
    Publication Date: 2020
    detail.hit.zdb_id: 2238238-0
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  • 10
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    Reply to Takeshita, W.M.; Ribeiro, D.A. Comment on “Pop et al. Early Diagnosis of Oral Mucosal Alterations in Smokers and E-Cigarette Users Based on Micronuclei Count: A Cross-Sectional Study among Dental Students. Int. J. Environ. Res. Public Health 2021, 18, 13246”
    MDPI AG ; 2022
    In:  International Journal of Environmental Research and Public Health Vol. 19, No. 7 ( 2022-03-24), p. 3845-
    Details
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 7 ( 2022-03-24), p. 3845-
    Abstract: Thank you for your interest [...]
    Type of Medium: Online Resource
    ISSN: 1660-4601
    URL: Article
    DOI: 10.3390/ijerph19073845
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175195-X
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