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  • 1
    In: Preventive Medicine, Elsevier BV, Vol. 153 ( 2021-12), p. 106761-
    Type of Medium: Online Resource
    ISSN: 0091-7435
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 1471564-8
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  • 2
    Online Resource
    Online Resource
    The Endocrine Society ; 2021
    In:  Journal of the Endocrine Society Vol. 5, No. Supplement_1 ( 2021-05-03), p. A302-A302
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 5, No. Supplement_1 ( 2021-05-03), p. A302-A302
    Abstract: Background: The mechanism for the association between total bilirubin (TBili) and dyslipidemia remains unclear. Total testosterone (TT) has been implicated in reducing bilirubin conjugation and decreasing atherogenic lipids. We hypothesized that 1) TBili was inversely associated with dyslipidemia, and 2) TT confounded this association. Methods: Our study population consisted of 5,878 (2,730 male and 3,148 non-pregnant female) adults aged ≥20 years from the 2011–2016 National Health and Nutrition Examination Survey (NHANES). We excluded those taking self-reported cholesterol medications. Participants with transaminitis (AST or ALT & gt;45 IU/L; AST/ALT & gt;5), excessive alcohol consumption ( & gt;20 drinks/week for males; & gt;10 for females), iron overload (transferrin & gt;50%), or positive hepatitis B/C serology were also excluded. We categorized TBili into sex-specific quartiles (Male: & lt;0.5, 0.5–0.6, 0.6–0.8, ≥0.8 mg/dl; Female: & lt;0.4, 0.4–0.5, 0.5–0.6, ≥0.6). Dyslipidemia was defined as elevated TG (≥150 mg/dl) or low HDL ( & lt;40 mg/dl for male; & lt;50 for female). We used survey design-adapted multivariable logistic regression, adjusting for TT, demographics, cardiometabolic factors, and liver function. We also stratified by sex-specific median TT levels (386 ng/dl in males; 18.5 ng/dl in females) to determine effect modification. Further, we determined whether the association between TBili and dyslipidemia persisted in males with TT deficiency ( & lt;280 ng/dl). Results: Among the 5,878 adults, 1,013 (38%) males & 958 (30%) females had elevated TG, and 803 (29%) males & 1,146 (33%) females had low HDL. Males in the highest quartile (Q4) of TBili had age-adjusted, mean (SD) 50.1 (3.5) mg/dl lower TG and 4.0 (0.9) mg/dl higher HDL than males in the lowest quartile (Q1; p & lt;0.0001). Females in Q4 had 36.4 (4.9) mg/dl lower TG and 5.1 (1.4) mg/dl higher HDL than Q1 (p & lt;0.0001). Males and females in Q4 had 60% and 59% lower odds, respectively, of elevated TG compared to Q1 (adjusted OR [95% CI]; Male: 0.40 [0.28, 0.57] , Female: 0.41 [0.32, 0.52]). Males and females in Q4 had 44% and 39% lower odds, respectively, of low HDL compared to Q1 (Male: 0.56 [0.38, 0.81] , Female: 0.61 [0.42, 0.90]). Adjusting for TT increased the parameter estimate for Q4, relative to the univariate estimate, by 21% in both sexes. There was no significant difference in TT-stratified odds of elevated TG or low HDL. Among the 544 (19%) males with TT deficiency, Q4 had 56% lower odds of elevated TG and 46% lower, but insignificant, odds of low HDL (aOR [95% CI] ; TG: 0.44 [0.21, 0.89], HDL: 0.54 [0.26, 1.12] ). Conclusion: TBili was inversely associated with elevated TG and low HDL. TT confounded, but did not modify, this association. Future studies examining TBili’s antiatherogenic role should adjust for TT.
    Type of Medium: Online Resource
    ISSN: 2472-1972
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2021
    detail.hit.zdb_id: 2881023-5
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  • 3
    Online Resource
    Online Resource
    The Endocrine Society ; 2021
    In:  Journal of the Endocrine Society Vol. 5, No. Supplement_1 ( 2021-05-03), p. A473-A474
    In: Journal of the Endocrine Society, The Endocrine Society, Vol. 5, No. Supplement_1 ( 2021-05-03), p. A473-A474
    Abstract: Background: Diabetes mellitus is a major cause of morbidity and mortality. Many individuals remain undiagnosed. The purpose of this study was to identify predictors of the lack of annual fasting blood sugar (FBS) testing in a representative cohort of U.S. adults. Methods: A total of 257,652 adults ≥18 years from the 2011–2018 National Health Interview Surveys (NHIS) were included. Participants were considered to have had FBS testing if they reported a fasting test for diabetes or high blood sugar in the past 12 months. Predictors of screening utilization were selected using the Anderson Model for Healthcare Utilization, including predisposing (age, sex, race/ethnicity), enabling (smoking, alcohol consumption, physical activity, insurance status, education, citizenship status, region of residence), need (BMI group, comorbidities, cardiovascular disease [CVD]), and healthcare-related factors (doctor visits, satisfactory care, affordability, delayed care). We used diabetes status-stratified multivariable logistic regression with a stepwise selection method to determine the most significant predictors. All analyses accounted for the survey design and weights to obtain nationally representative estimates. Results: Among the 257,652 participants, 115,630 (48%) were male, 27,096 (9.4%) had diabetes, and 141,247 (56%) did not have a FBS test in the past 12 months. Among those with diabetes, 4,529 (16%) did not have a FBS test. Positive predictors of a lack of FBS testing included younger age, male sex, non-Hispanic Black race, ever smoker (≥100 cigarettes), native born, lack of insurance coverage, lack of adequate physical activity, northeast region (relative to west region), no known chronic diseases, and dissatisfactory care. The top 5 most significant predictors of a lack of FBS test in those without diabetes were, in order, 1) no visits to the doctor in the past 12 months (aOR [95% CI]; 5.64 [5.34, 5.96] ), 2) insurance status (no coverage vs. coverage; 1.62 [1.54, 1.69]), 3) age group (Ref: ≥65y; 18-35y: 2.45 [2.34, 2.56] ; 35-50y: 1.46 [1.40, 1.52]; 50-65y: 1.04 [1.01, 1.08] ), 4) BMI group (Ref: Low/Normal; Overweight: 0.79 [0.77, 0.82]; Obese: 0.62 [0.60, 0.64] ), and 5) race/ethnicity (Ref: Non-Hispanic White; Non-Hispanic Black: 1.03 [0.98, 1.07], Asian Indian: 0.65 [0.58, 0.74] ; Other Asian: 0.91 [0.83, 1.00]; Hispanic/Multiracial: 0.91 [0.86, 0.96] ). The top predictors for those with diabetes were similar, although there were significantly greater odds of a lack of FBS testing in Non-Hispanic Blacks vs. Whites (1.24 [1.14, 1.35]). Conclusion: More than half of the participants reported a lack of FBS testing in the past year; among those with diabetes, nearly 1 in 6 reported not having an annual FBS test. This reaffirms the need for long-term patient-physician relationships and aggressive follow-up in younger, male, uninsured, and/or lean individuals with or without diabetes.
    Type of Medium: Online Resource
    ISSN: 2472-1972
    Language: English
    Publisher: The Endocrine Society
    Publication Date: 2021
    detail.hit.zdb_id: 2881023-5
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  • 4
    Online Resource
    Online Resource
    Elsevier BV ; 2021
    In:  Journal of the American College of Cardiology Vol. 77, No. 18 ( 2021-05), p. 1654-
    In: Journal of the American College of Cardiology, Elsevier BV, Vol. 77, No. 18 ( 2021-05), p. 1654-
    Type of Medium: Online Resource
    ISSN: 0735-1097
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 1468327-1
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  • 5
    In: COVID, MDPI AG, Vol. 3, No. 5 ( 2023-04-25), p. 682-692
    Abstract: (1) Background: Data on COVID-19 outcomes and disease course as a function of different medications used to treat cardiovascular disease and chronic kidney disease (CKD), as well as the presence of different comorbidities in primarily Black cohorts, are lacking. (2) Methods: We conducted a retrospective medical chart review on 327 patients (62.6% Black race) who were admitted to the Detroit Medical Center, Detroit, MI. Group differences (CKD vs. non-CKD) were compared using the Pearson χ2 test. We conducted univariate and multivariate regression analyses for factors contributing to death during hospitalization due to COVID-19 (primary outcome) and ICU admission (secondary outcome), adjusting for age, sex, different medications, and comorbidities. A sub-analysis was also completed for CKD patients. (3) Results: In the fully adjusted model, a protective effect of ACEi alone, but not in combination with ARB or CCB, for ICU admission was found (OR = 0.400, 95% CI [0.183–0.874]). Heart failure was significantly associated with the primary outcome (OR = 4.088, 95% CI [1.1661–14.387] ), as was COPD (OR = 3.747, 95% CI [1.591–8.828]). (4) Conclusions: Therapeutic strategies for cardiovascular disease and CKD in the milieu of different comorbidities may need to be tailored more prudently for individuals with COVID-19, especially Black individuals.
    Type of Medium: Online Resource
    ISSN: 2673-8112
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 3056217-X
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  • 6
    In: Physiology, American Physiological Society, Vol. 38, No. S1 ( 2023-05)
    Abstract: Early on in the COVID-19 pandemic it was reported that angiotensin converting enzyme 2 inhibitors (ACE2i) could be associated with worse disease course due to potential increase in ACE2 receptors which SARS-CoV2 virus uses for cellular entry. Subsequent studies refuted such concerns, reporting that the continued use of ACEis and angiotensin receptor blockers (ARBs) in hypertensive individuals is in fact protective. Moreover, certain comorbidities, such as hypertension and heart disease, have been linked to an increased risk of disease severity. However, there is still paucity of data evaluating the effects of the use of different antihypertensive medications, steroids and beta blockers in chronic kidney disease (CKD) populations and in individuals with normal kidney function. This study was designed to evaluate the potential risk associated with renin angiotensin system inhibitors, calcium channel blocker, mineralocorticoid receptor blocker, steroids and beta blockers in a cohort of mostly African Americans and Caucasians. We conducted a retrospective study on patients who were admitted to the Detroit Medical Center, Detroit, MI during March and April of 2020. The data were collected through the medical chart reviews. We assessed 330 patients using inclusion criteria of age 〉 18 years and a positive SARS-CoV2 PCR test. We used the mean, standard deviation/standard error of mean, and percentages when appropriate for the description of patient characteristics. Group differences (CKD vs. non-CKD) were compared using the Pearson χ2 test. P-values of 〈 0.05 were regarded as significant. We conducted binary logistic regression analysis to determine the effect of biological sex and CKD status on death due to COVID-19 during hospitalization. We conducted multivariate regression analysis for factors contributing to death during hospitalization due to COVID-19 and ICU admission, evaluating the contribution of different medications, comorbidities, and clinical course of the disease. On regression analyses, the odds of death in the hospital due to COVID-19 infection was not significantly associated with either biological sex or CKD status in our sample population. The odds of dying in the hospital were higher in patients who were on calcium channel blockers (OR 2.99, 95% CI 1.29-6.93, P = 0.01) and steroids (OR 4.23, 95% CI 1.17-15.31, P = 0.03). The only significance for ICU admission was obtained for steroid use (OR 1.872, 95% CI 1.059-3.311, P = 0.03). Likewise, COPD was the only comorbidity found to be associated with ICU admission (OR 2.38, 95% CI 1.282 - 4.426, P = 0.006), Significant associations were not observed for patients taking ACEis, ARBs, mineralocorticoid receptor inhibitors, diuretics, beta blockers and sympatholytics. This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.
    Type of Medium: Online Resource
    ISSN: 1548-9213 , 1548-9221
    Language: English
    Publisher: American Physiological Society
    Publication Date: 2023
    detail.hit.zdb_id: 3115360-4
    detail.hit.zdb_id: 2005759-3
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Functional Food Center ; 2020
    In:  Bioactive Compounds in Health and Disease Vol. 3, No. 11 ( 2020-11-16), p. 204-
    In: Bioactive Compounds in Health and Disease, Functional Food Center, Vol. 3, No. 11 ( 2020-11-16), p. 204-
    Abstract: Marginalized populations face health disparity due to multiple different avenues during the 2020 COVID-19 pandemic:        1.Direct COVID-19 infection and hospitalization,        2.Poor overall health and nutrition leading tocomorbidity and worsened outcomes, and        3.Difficult social conditions such as workplacehygiene, living conditions, and transportation.These three identified issues are cyclical in nature and both cause and affect the others. This article studies each of these factors using a literature review, especially in the experience of certain demographics, including elderly, low-income, racial minorities, urban, and institutionalized persons. We then delve into recommendations that can be considered for each of these issues and specific populations. Recommendations can be given to policymakers, public health officials, and epidemiologists as well as basic science researchers and food producers to attack the disparity from both sides. These findings and ideas may be used to improve both nutrition accessibility as well as COVID-19 disparity for these most vulnerable populations.Keywords: COVID-19, SARS-CoV-2, coronavirus, deficiency, elderly, urban, race, socioeconomic status, disparity, nutrition, diet
    Type of Medium: Online Resource
    ISSN: 2574-0334 , 2769-2426
    Language: Unknown
    Publisher: Functional Food Center
    Publication Date: 2020
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  • 8
    Online Resource
    Online Resource
    Functional Food Center ; 2020
    In:  Bioactive Compounds in Health and Disease Vol. 3, No. 7 ( 2020-07-31), p. 109-
    In: Bioactive Compounds in Health and Disease, Functional Food Center, Vol. 3, No. 7 ( 2020-07-31), p. 109-
    Abstract: The disease COVID-19, caused by the SARS-CoV-2 coronavirus, disproportionately targets individuals with aging or otherwise dysfunctional immunity. Since nutrition is shown to have a massive effect on the immune system—and other body systems that can both improve protection and ability to fight against the SARS-CoV-2 virus—we conducted a literature review of nutrition recommendations and their antiviral effects in older adult populations. Certain bioactive compounds and functional foods have been shown in the past to improve the body’s immune function and prevent viral infection. We organize our recommendations by food groups, as delineated by the MyPlate nutritional program, to create guidelines for senior citizens, public health experts, nutritionists, caretakers, and nursing homes. We hope this research will assist in improving the age disparity in vulnerability to the disease COVID-19 during the pandemic.Keywords: COVID-19, SARS-CoV-2, coronavirus, infection, pandemic, deficiency, health, nutrition, immunity, diet, elderly, aging, senior citizens
    Type of Medium: Online Resource
    ISSN: 2574-0334 , 2769-2426
    Language: Unknown
    Publisher: Functional Food Center
    Publication Date: 2020
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  • 9
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Journal of Hypertension Vol. 39, No. 5 ( 2021-05), p. 1044-1045
    In: Journal of Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 39, No. 5 ( 2021-05), p. 1044-1045
    Type of Medium: Online Resource
    ISSN: 0263-6352 , 1473-5598
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2017684-3
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  • 10
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Journal of Hypertension Vol. 39, No. 7 ( 2021-07), p. 1469-1470
    In: Journal of Hypertension, Ovid Technologies (Wolters Kluwer Health), Vol. 39, No. 7 ( 2021-07), p. 1469-1470
    Type of Medium: Online Resource
    ISSN: 0263-6352 , 1473-5598
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2017684-3
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