In:
Drug Intelligence & Clinical Pharmacy, SAGE Publications, Vol. 22, No. 2 ( 1988-02), p. 130-133
Abstract:
The influence of enteral feedings (with Ensure) on the absorption of phenytoin sodium from capsules was studied. Six healthy adult volunteers were given a single dose of phenytoin capsules 400 mg po on two occasions. Blood specimens were collected for 48 hours after each dose. In a randomized, crossover fashion, each subject completed the following two phases: (1) phenytoin without enteral feedings, and (2) concomitant enteral feedings before phenytoin and continued at 100 ml/h for ten hours. The areas under the concentration versus time curves from 0-48 hours (AUCo-48) were not significantly different between the two phases (p 〉 0.5). The percent relative bioavailability of phenytoin with enteral feedings was 101.7 percent. This study suggests that enteral feedings do not affect the serum concentrations of phenytoin after a single dose given in capsule form.
Type of Medium:
Online Resource
ISSN:
0012-6578
DOI:
10.1177/106002808802200205
Language:
English
Publisher:
SAGE Publications
Publication Date:
1988
detail.hit.zdb_id:
2053518-1
SSG:
15,3
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