In:
International Journal of Cancer, Wiley, Vol. 133, No. 12 ( 2013-12-15), p. 2812-2823
Abstract:
What's new? Solid tumors have an increased reliance on Hsp70/Hsp90 molecular chaperones for proliferation, survival, and maintenance of intracellular signaling systems. An under‐studied co‐chaperone is SGTA, which is an inhibitor of androgen receptor transcriptional activity in prostate cancer cells. This study presents new data showing that SGTA acts to regulate multiple oncogenic signaling pathways in prostate cancer. Specifically, SGTA acts to maintain optimal expression of genes within the androgen and PI3 kinase pathways. SGTA is also required for maximal Akt activity and overall cell viability. The biological relationships between SGTA, the androgen receptor, and PI3/Akt may be of importance in prostate tumorigenesis.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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