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  • 1
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2016
    In:  Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere Vol. 44, No. 03 ( 2016), p. 200-208
    In: Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere, Georg Thieme Verlag KG, Vol. 44, No. 03 ( 2016), p. 200-208
    Abstract: Unzureichend behandelte Schmerzen führen zu negativen systemischen Effekten und unter Umständen zu einer massiven Störung des Allgemeinbefindens unserer Patienten. Aus diesem Grund sollte ein Schmerzbeurteilungsplan standardmäßig in die klinischen Abläufe eingebunden sein. Für Hund und Katze stehen validierte Schmerz - beurteilungspläne zur Verfügung. Im Rahmen einer fortschrittlichen Schmerztherapie ist das Prinzip der multimodalen Analgesie zu beachten. Dies bedeutet, dass verschiedene analgetische Wirkstoffgruppen miteinander kombiniert werden, die ihre Wirkung an unterschiedlichen Stellen des Schmerzentstehungs- und Schmerzleitungssystems entfalten. Neben Opioiden, nichtsteroidalen Antiphlogistika und Lo - kalanästhetika finden unter anderem α2-Rezeptor-Agonisten, Ketamin und Gabapentin Anwendung. Hinzu kommen diverse nichtpharmakologische Therapieformen.
    Type of Medium: Online Resource
    ISSN: 1434-1239 , 2567-5842
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2016
    SSG: 22
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  • 2
    Online Resource
    Online Resource
    Elsevier BV ; 2011
    In:  The Veterinary Journal Vol. 187, No. 3 ( 2011-3), p. 335-341
    In: The Veterinary Journal, Elsevier BV, Vol. 187, No. 3 ( 2011-3), p. 335-341
    Type of Medium: Online Resource
    ISSN: 1090-0233
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2011
    detail.hit.zdb_id: 2002624-9
    SSG: 22
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  • 3
    In: The Annals of Thoracic Surgery, Elsevier BV, Vol. 81, No. 4 ( 2006-04), p. 1472-1479
    Type of Medium: Online Resource
    ISSN: 0003-4975
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2006
    detail.hit.zdb_id: 1499869-5
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  • 4
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2020-06-04)
    Abstract: Bone replacement and osteosynthesis require materials which can at least temporarily bear high mechanical loads. Ideally, these materials would eventually degrade and would be replaced by bone deposited from the host organism. To date several metals, notably iron and iron-based alloys have been identified as suitable materials because they combine high strength at medium corrosion rates. However, currently, these materials do not degrade within an appropriate amount of time. Therefore, the aim of the present study is the development of an iron-based degradable sponge-like (i.e. cellular) implant for bone replacement with biomechanically tailored properties. We used a metal powder sintering approach to manufacture a cylindrical cellular implant which in addition contains phosphor as an alloying element. No corrosion inhibiting effects of phosphorus have been found, the degradation rate was not altered. Implant prototypes were tested in an animal model. Bone reaction was investigated at the bone-implant-interface and inside the cellular spaces of the implant. Newly formed bone was growing into the cellular spaces of the implant after 12 months. Signs of implant degradation were detected but after 12 months, no complete degradation could be observed. In conclusion, iron-based open-porous cellular biomaterials seem promising candidates for the development of self-degrading and high load bearing bone replacement materials.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2615211-3
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  • 5
    In: Technology and Health Care, IOS Press, Vol. 31, No. 5 ( 2023-09-15), p. 1867-1874
    Abstract: BACKGROUND: Over the last 50 years arthroplasty became the gold-standard treatment for disabling conditions of the coxofemoral joint. Variations of anterior, lateral, and dorsal incision have been applied, but as each approach requires the incision and reflection of various muscles to gain adequate exposure of the joint results are still controversial. OBJECTIVE: The purpose of this study was to develop a minimal-invasive, tissue-sparing approach in sheep with reduced risks in animal testing. METHODS: 12 mature sheep underwent hip surgery as part of a study to evaluate a hip resurfacing system. In line with the preliminary cadaveric tests a modified, minimal-invasive, musclepreserving surgical approach was sought after. RESULTS: We developed a surgical approach to the coxofemoral joint in sheep using only blunt tissue dissection after skin incision without any limitations in joint exposure or increased blood loss/duration of surgery. CONCLUSION: Even though limitations occur and femoral orientation in sheep differs from man, joint forces have similar relative directions to the bone with similar bony and vascular anatomy. Therefore, this minimal-invasive muscle preserving approach might be a safe and comparable alternative in still inevitable animal testing.
    Type of Medium: Online Resource
    ISSN: 0928-7329 , 1878-7401
    Language: Unknown
    Publisher: IOS Press
    Publication Date: 2023
    detail.hit.zdb_id: 2043772-9
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  • 6
    Online Resource
    Online Resource
    American Veterinary Medical Association (AVMA) ; 2016
    In:  Journal of the American Veterinary Medical Association Vol. 249, No. 7 ( 2016-10-01), p. 794-800
    In: Journal of the American Veterinary Medical Association, American Veterinary Medical Association (AVMA), Vol. 249, No. 7 ( 2016-10-01), p. 794-800
    Abstract: CASE DESCRIPTION A 4-year-old male Dachshund was examined following a bite attack that had occurred 5 days previously. The dog had acutely deteriorated despite IV antimicrobial treatment and fluid therapy. CLINICAL FINDINGS On initial examination, the patient was recumbent with signs of septic shock and a flail chest. Three penetrating wounds in the left thoracic wall with malodorous discharge were evident. The animal trauma triage score was 8 out of 18. Thoracic and abdominal radiography revealed displaced fractures of the left seventh, eighth, and ninth ribs and extensive subcutaneous emphysema. Additionally, a marked diffuse bronchointerstitial pattern, areas of alveolar pattern, and pneumothorax were present bilaterally. TREATMENT AND OUTCOME Open surgical debridement with left lateral lung lobectomy and resection of portions of the left thoracic wall were performed. Extensive soft tissue loss precluded primary reconstruction. The defect was stabilized with a polypropylene mesh implant, and negative pressure wound therapy (NPWT) at −100 mm Hg was initiated. Microbial culture and susceptibility testing of tissue samples indicated the presence of multidrug-resistant Staphylococcus pseudintermedius . The NPWT dressing was changed 2, 5, and 7 days after surgery. Treatment was well tolerated, and the mesh was completely covered with granulation tissue 10 days after surgery. On follow-up 5, 7, 12, and 19 months after surgery, the dog was clinically normal with no apparent complications. CLINICAL RELEVANCE Findings suggested that NPWT may be a valuable adjunct when treating small animal patients with severe thoracic trauma.
    Type of Medium: Online Resource
    ISSN: 0003-1488
    Language: Unknown
    Publisher: American Veterinary Medical Association (AVMA)
    Publication Date: 2016
    detail.hit.zdb_id: 2904887-4
    SSG: 22
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  • 7
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2021-06-08)
    Abstract: Despite the high potential of healthy bone to regenerate, the reconstruction of large bone defects remains a challenge. Due to the lack of mechanical stability of existing bone substitutes, recently developed degradable metallic alloys are an interesting alternative providing higher load-bearing capabilities. Degradable iron-based alloys therefore might be an attractive innovation. To test the suitability of a newly-designed iron-based alloy for such applications, an animal experiment was performed. Porous iron-based degradable implants with two different densities and a control group were tested. The implants were positioned in the proximal tibia of Merino sheep. Over a period of 6 and 12 months, blood and histological parameters were monitored for signs of inflammation and degradation. In the histological evaluation of the implants` environment we found degraded alloy particles, but no inflammatory reaction. Iron particles were also found within the popliteal lymph nodes on both sides. The serum blood levels of phosphorus, iron and ferritin in the long term groups were elevated. Other parameters did not show any changes. Iron-based degradable porous bone replacement implants showed a good biocompatibility in this experiment. For a clinical application, however, the rate of degradation would have to be significantly increased. Biocompatibility would then have to be re-evaluated.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2615211-3
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  • 8
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2016
    In:  Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere Vol. 44, No. 04 ( 2016), p. 261-271
    In: Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere, Georg Thieme Verlag KG, Vol. 44, No. 04 ( 2016), p. 261-271
    Type of Medium: Online Resource
    ISSN: 1434-1239 , 2567-5842
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2016
    SSG: 22
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  • 9
    Online Resource
    Online Resource
    Georg Thieme Verlag KG ; 2019
    In:  Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere Vol. 47, No. 06 ( 2019-12), p. 412-418
    In: Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere, Georg Thieme Verlag KG, Vol. 47, No. 06 ( 2019-12), p. 412-418
    Abstract: Gegenstand und Ziel Untersuchung des perioperativen Temperaturverlaufs bei gleichzeitiger Anwendung von Acepromazin und Metamizol (AM) im Vergleich zur Anwendung von Acepromazin alleine (A). Material und Methoden In dieser prospektiven, quasi-randomisierten, kontrollierten Studie wurden 20 Hunde, bei denen eine standar disierte Tibial Plateau Leveling Osteotomy erfolgte, hinsichtlich der Prämedikation alternierend 2 Gruppen (A und AM) zugeordnet (je n = 10). Der Verlauf der Rektaltemperaturen wurde ab der Prämedikation bis zum Wiedererreichen einer physiologischen Körpertemperatur nach der Narkose überwacht. Ergebnisse Der Abfall der Temperatur während der Narkose war bei beiden Gruppen vergleichbar (p = 0,12). Postoperativ differierten die Temperaturverläufe der beiden Gruppen signifikant (p = 0,0455). Bei 6 Hunden, die Metamizol erhalten hatten, fiel die Temperatur nach Extubation weiter ab, bevor sie wieder auf physiologische Werte anstieg. Schlussfolgerung Unabhängig von der Studiengruppe entwickelten alle Probanden intraoperativ eine Hypothermie. Postoperativ stabilisierte sich die Körpertemperatur in Gruppe A schneller als in Gruppe AM.
    Type of Medium: Online Resource
    ISSN: 1434-1239 , 2567-5842
    Language: German
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2019
    SSG: 22
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  • 10
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Journal of Feline Medicine and Surgery Vol. 21, No. 10 ( 2019-10), p. 938-943
    In: Journal of Feline Medicine and Surgery, SAGE Publications, Vol. 21, No. 10 ( 2019-10), p. 938-943
    Abstract: A prospective experimental study was performed in nine young healthy cats to investigate a pharmacokinetic profile and the clinical relevance of rectally administered buprenorphine. Rectal pH value was measured in all nine cats. Methods Blood was collected 15, 30, 60, 90, 120, 240 and 480 mins and 24 h after the rectal administration of a suppository and a gel at doses between 0.02 mg/kg and 0.1 mg/kg buprenorphine to determine the plasma concentration of buprenorphine. Rectal pH was measured with pH paper. Results Upon pharmacokinetic non-compartment analysis of high-dose buprenorphine (0.1 mg/kg), average maximal plasma concentration was found to be 1.13 ng/ml, time to maximal plasma concentration was 45 mins and area under the plasma concentration–time curve was 94.19 ng*min/ml, representing low but potential bioavailability. Mean residual time was 152.2 mins and the half-life was 92.6 mins. A wide range of plasma concentrations within the cohort was measured and two of the cats had to be excluded from statistical analysis owing to incomplete uptake. Vital parameters of all cats were considered to be normal but three of the cats showed mydriasis up to 8 h after application. After the administration of a low-dose suppository or a rectal gel (0.02 mg/kg) within pilot studies, no buprenorphine was detected in cat plasma. Rectal pH in all cats was between 7.7 and 8. Conclusions and relevance The rectal application of buprenorphine at a dose of 0.1 mg/kg revealed a potential but weak uptake in cats. Regarding effective concentrations in previous pharmacokinetic investigations, rectal administration is currently not recommended for good provision of opioid analgesia in cats. Pharmacological investigations of formulation and galenics in order to improve the rectal bioavailability of buprenorphine remain to be clarified before further dose-finding and pharmacokinetic/pharmacodynamic studies are performed.
    Type of Medium: Online Resource
    ISSN: 1098-612X , 1532-2750
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2049047-1
    SSG: 22
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