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  • 1
    Online Resource
    Online Resource
    Exploration of Remarkably Potential Multitarget-Directed NAlkylated-2-(substituted phenyl)1Hbenzimidazole Derivatives as Antiproliferative, Antifungal and Antibacterial Agents
    American Chemical Society (ACS) ; 2023
    In:  ACS Omega Vol. 8, No. 31 ( 2023-08-08), p. 28733-28748
    Details
    In: ACS Omega, American Chemical Society (ACS), Vol. 8, No. 31 ( 2023-08-08), p. 28733-28748
    Type of Medium: Online Resource
    ISSN: 2470-1343 , 2470-1343
    URL: Article
    URL: Article
    DOI: 10.1021/acsomega.3c03530
    DOI: 10.1021/acsomega.3c03530.s001
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2023
    detail.hit.zdb_id: 2861993-6
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  • 2
    Online Resource
    Online Resource
    Antiproliferative, Anti-Inflammatory Activities, and Molecular Docking Studies of Secondary Metabolites from Macrosolen tricolor
    Hindawi Limited ; 2023
    In:  Journal of Chemistry Vol. 2023 ( 2023-1-2), p. 1-9
    Details
    In: Journal of Chemistry, Hindawi Limited, Vol. 2023 ( 2023-1-2), p. 1-9
    Abstract: In Vietnam, Macrosolen tricolor is used for the treatment of bloating, broken bones, cough, diarrhea, diuretic, rheumatism, and laxative effects. The study aimed to identify the in vitro antiproliferation and anti-inflammation of all fractions and purified compounds from the M. tricolor whole plants, as well as the in silico molecular docking of the potentially cytotoxic compounds. As the results, fractions (MTH.I, MTH.II, MTE.I, and MTE.II) strongly demonstrated antiproliferative properties against three tested cells, MDA-MB-231, RD, and HepG2 (IC50 values ranged from 4.00 ± 0.20 to 70.60 ± 1.44 μg/mL), as well as anti-inflammatory effects (IC50 values ranged from 4.45 ± 0.08 to 23.00 ± 1.18 μg/mL), whereas other fractions meaningfully evidenced selective cytotoxicity and/or anti-inflammation. Therefore, the phytochemical compositions of the active fractions were illuminated, leading to the characterization of eighteen compounds. Compounds (3–5) revealed the most cytotoxic effects towards all examined cells (IC50 values ranged from 6.88 ± 0.12 to 71.64 ± 1.17 μM) and the strongest anti-inflammatory properties (IC50 values of 16.30 ± 0.92, 7.31 ± 0.55, and 9.23 ± 0.60 μM, respectively). Compound 11 showed potential cytotoxicity against MDA-MB-231, RD, and HepG2 cells (IC50 values of 24.42 ± 0.28, 20.60 ± 0.25, and 3.20 ± 0.02 μM, respectively). Furthermore, compounds (4, 5, and 11) interacted with the active site of the apoptosis regulator Bcl-2 protein (PDB ID: 2O2F), were comparable to PAC, and were compatible with their anticancer activity. This project suggests that M. tricolor is a good source of natural antiproliferative and anti-inflammatory agents and contributes to understanding the biological activities of Macrosolen species in traditional Vietnamese medicine.
    Type of Medium: Online Resource
    ISSN: 2090-9071 , 2090-9063
    URL: Article
    DOI: 10.1155/2023/7977620
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2023
    detail.hit.zdb_id: 2393625-3
    detail.hit.zdb_id: 2703077-5
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  • 3
    Online Resource
    Online Resource
    Bridging Therapy and Direct Thrombectomy for Acute Ischemic Stroke: A Prospective Cohort Study
    SAGE Publications ; 2020
    In:  Journal of Stroke Medicine Vol. 3, No. 2 ( 2020-12), p. 124-130
    Details
    In: Journal of Stroke Medicine, SAGE Publications, Vol. 3, No. 2 ( 2020-12), p. 124-130
    Abstract: It remains controversial if intravenous thrombolysis (IVT) prior to mechanical thrombectomy (MTE) is superior to MTE alone in patients with acute ischemic stroke caused by large vessel occlusion. We aim to compare functional outcomes, mortality, reperfusion, and intracranial hemorrhage rates in bridging therapy (IVT prior thrombectomy) and MTE alone groups within 6 h from symptom onset. Materials and Methods: Consecutive hospitalized patients (September 2017 and July 2018) with acute large artery occlusion within the anterior cerebral circulation eligible for MTE with or without prior IVT were included. A modified Rankin Scale score of 0 to 2 was considered as good functional outcome at 90 days. Successful reperfusion was defined as a Thrombolysis in Cerebral Infarction scale of 2b to 3. Results: Of the 124 patients included, 56 (45.2%) received bridging therapy and 68 (54.8%) received MTE alone. Patients receiving bridging therapy were younger (median, 56 vs 63, P = .045) and had shorter onset-to-groin time (median, 270 vs 370 min, P 〈 .001) than those receiving MTE alone. Successful reperfusion rate was significantly greater in the bridging therapy group (87.5% vs 72.1%, P = 0.03). There were no statistically significant differences between the 2 groups in functional independence (bridging 58.9% vs 75.0%, P = 0.07), mortality at 90 days (bridging 14.3% vs 7.4%, P = 0.22), parenchymal hematoma type 2 (bridging 3.6% vs 2.9%, P 〉 .99), and any hemorrhage (bridging 42.3% vs 26.5%, P = 0.07). Conclusion: Compared to MTE alone, bridging therapy with IVT improved the reperfusion rate but not other outcomes. Further clinical trials are needed to confirm our findings.
    Type of Medium: Online Resource
    ISSN: 2516-6085 , 2516-6093
    URL: Article
    DOI: 10.1177/2516608520976275
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2020
    detail.hit.zdb_id: 3011515-2
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  • 4
    Online Resource
    Online Resource
    STUDY ON TRANSCRIPTION POSSIBILITY OF EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) GENE IN BREAST CARCINOMA TISSUES BY REVERSE TRANSCRIPTION-PCR ASSAY
    Hue University of Medicine and Pharmacy ; 2015
    In:  Journal of Medicine and Pharmacy
    Details
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy
    Abstract: Background: EGFR is a member of the EGFR family- type I transmembrane tyrosine kinase receptors, which plays an essential role in development and growth of body. However, EGFRs are frequently overexpressed, this overexpression and its signal pathway induce unrestricted development and uncontrolled proliferation in human malignant tumors including breast carcinoma, one of the most common cancer in women. Objective: (1)To evaluate transcript level of EGFR gene in breast carcinoma tissues by RT-PCR assay.(2)To compare transcript level of EGFR gene in breast carcinoma with breast fibro adenoma. Subject and Methods: total RNA from 70 samples including 38 breast carcinoma tissues and 32 breast fibroadenoma tissues were extracted. EGFR transcript level were determined using semi-quantitative Reverse Transcription-PCR assay. PCR products were tested by electrophoresis on agarose gel 2%. Results: RNA total concentration in breast carcinoma tissues was 170.03 ± 201.17 ng/µl, was significantly higher in breast fibro adenoma tissue: 65.96 ± 43.16 ng/µl (p 〈 0.05). EGFR transcript level was highly expressed in breast carcinoma compared to breast fibro adenoma (1.22 ± 0.24 compared to 0.75 ± 0,19) (p 〈 0.0001). The cut-off point of the rate EGFR/GAPDH was 0.97, area under the curve: 0.913, p 〈 0.0001, sensitivity and specificity were 81,58% and 93.75%. Conclusion: Transcript level of EGFR gene in breast carcinoma was significantly 1.63 times higher than in breast fibro-adenoma. The cut-off point of the rate EGFR/GAPDH was 0.97, sensitivity: 81.58% and specificity: 93.75%. Key words: EGFR, RT-PCR, breast carcinoma
    Type of Medium: Online Resource
    ISSN: 1859-3836
    URL: Journal
    URL: Article
    DOI: 10.34071/jmp
    DOI: 10.34071/jmp.2015.3.4
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2015
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  • 5
    Online Resource
    Online Resource
    ẢNH HƯỞNG CỦA DỊCH CHIẾT VI KHUẨN LAM ĐẾN NHÂN GIỐNG IN VITRO CÂY LAN HOÀNG THẢO GIẢ HẠC (Dendrobium anosmum Lindl.)
    Hue University ; 2022
    In:  Hue University Journal of Science: Natural Science Vol. 131, No. 1C ( 2022-09-30), p. 73-82
    Details
    In: Hue University Journal of Science: Natural Science, Hue University, Vol. 131, No. 1C ( 2022-09-30), p. 73-82
    Abstract: Protocorm của cây lan Hoàng thảo Giả hạc (Dendrobium anosmum Lindl.) bốn tuần tuổi được sử dụng để làm vật liệu khởi đầu cho nhân giống in vitro. Dịch chiết gốc vi khuẩn lam Arthrospira sp. được tạo thành bằng cách nghiền 1 g sinh khối tươi trong 100 mL nước cất. Kết quả cho thấy dịch chiết vi khuẩn lam có tác dụng tăng cường sự nhân chồi và ra rễ của cây lan Hoàng thảo Giả hạc nuôi cấy in vitro. Môi trường MS cơ bản bổ sung 6 g·L–1 agar, 30 g·L–1 saccharose và 1,5 mg·L–1 BAP kết hợp với 20 mL·L–1 dịch chiết vi khuẩn lam thích hợp cho sự nhân protocorm và môi trường tối ưu cho nhân chồi. Đường kính cụm protocorm thu được là 2,43 cm. Môi trường MS cơ bản bổ sung 6 g·L–1 agar, 30 g·L–1 saccharose và 1,0 mg·L–1 BAP kết hợp với 20 mL·L–1 dịch chiết vi khuẩn lam là môi trường tối ưu cho nhân chồi, số chồi/mẫu đạt 4,7; chồi cao 1,37 cm. Môi trường MS cơ bản bổ sung 6 g·L–1 agar, 30 g·L–1 saccharose và 1,5 mg·L–1 NAA kết hợp với 30 mL·L–1 dịch chiết vi khuẩn lam thích hợp nhất cho tạo rễ từ chồi in vitro với 4,87 rễ/chồi; chiều dài rễ là 0,74 cm và chiều cao chồi là 2,76 cm. Kết quả này sẽ mở ra triển vọng ứng dụng dịch chiết vi khuẩn lam giúp giảm chi phí trong công nghệ nuôi cấy mô tế bào thực vật.
    Type of Medium: Online Resource
    ISSN: 2615-9678 , 1859-1388
    URL: Issue
    URL: Article
    DOI: 10.26459/hueunijns.v131i1C
    DOI: 10.26459/hueunijns.v131i1C.6564
    Language: Unknown
    Publisher: Hue University
    Publication Date: 2022
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  • 6
    Online Resource
    Online Resource
    The Factors Affecting the Level of Information Disclosure on Financial Statements in the Industrial Enterprises Listed on Ho Chi Minh Stock Exchange
    Scholink Co, Ltd. ; 2019
    In:  Journal of Economics and Public Finance Vol. 5, No. 1 ( 2019-02-21), p. 93-
    Details
    In: Journal of Economics and Public Finance, Scholink Co, Ltd., Vol. 5, No. 1 ( 2019-02-21), p. 93-
    Abstract: 〈 p 〉 〈 em 〉 This research analyzes the factors affecting the level of information disclosure on financial statements in the industrial enterprises listed on Ho Chi Minh stock exchange. Using financial statements of 87 industrial enterprises of the fiscal year 2017, the research shows that there are 6 factors affecting and having a positive relations with the level of information disclosure. These include: the scale of business, Duration of operation, Audit firm reputation, Solvency, Financial leverage and Return on Equity (ROE). The result points to signals that help the State Securities Commission to control better of information disclosure of firms. In addition, the study recommends measures for shareholders, especially those in large companies to strengthen the supervision, control managers in the disclosure of business information. 〈 /em 〉 〈 /p 〉
    Type of Medium: Online Resource
    ISSN: 2377-1046 , 2377-1038
    URL: Article
    DOI: 10.22158/jepf.v5n1p93
    Language: Unknown
    Publisher: Scholink Co, Ltd.
    Publication Date: 2019
    detail.hit.zdb_id: 2841435-4
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  • 7
    Online Resource
    Online Resource
    Factors Affecting on the Capital Structure of Real Estate Joint-Stock Companies Listed on Vietnam’s Stock Exchange
    Scholink Co, Ltd. ; 2022
    In:  Journal of Economics and Public Finance Vol. 8, No. 2 ( 2022-05-19), p. p121-
    Details
    In: Journal of Economics and Public Finance, Scholink Co, Ltd., Vol. 8, No. 2 ( 2022-05-19), p. p121-
    Abstract: This study is conducted to evaluate and analyze factors affecting the capital structure of real estate joint-stock companies listed on Vietnam’s stock exchange for more than 5 years or more. The research uses a regression model for table data in which data is collected from the consolidated financial statements and other information of 55 joint-stock companies in the real estate industry from the period 2015 - 2019. The result indicates that factors such as firm size, age of the Chairman of the Board and return on equity (ROE) have a positive effect on capital structure. In contrast, factors such as operating time, gender, liquidity, asset turnover ratio, and return on total assets (ROA) have a negative impact on the capital structure of real estate joint-stock companies. In general, the women-chaired enterprises have a higher debt ratio than those of males. However, the higher age of the men-chaired enterprises, the higher the debt ratio their enterprises have compared to women-chaired enterprises.
    Type of Medium: Online Resource
    ISSN: 2377-1046 , 2377-1038
    URL: Article
    DOI: 10.22158/jepf.v8n2p121
    Language: Unknown
    Publisher: Scholink Co, Ltd.
    Publication Date: 2022
    detail.hit.zdb_id: 2841435-4
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  • 8
    Online Resource
    Online Resource
    Pegylated Dendrimer and Its Effect in Fluorouracil Loading and Release for Enhancing Antitumor Activity
    American Scientific Publishers ; 2013
    In:  Journal of Biomedical Nanotechnology Vol. 9, No. 2 ( 2013-02-01), p. 213-220
    Details
    In: Journal of Biomedical Nanotechnology, American Scientific Publishers, Vol. 9, No. 2 ( 2013-02-01), p. 213-220
    Type of Medium: Online Resource
    ISSN: 1550-7033
    URL: Article
    DOI: 10.1166/jbn.2013.1479
    Language: English
    Publisher: American Scientific Publishers
    Publication Date: 2013
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  • 9
    Online Resource
    Online Resource
    ASSESSING THE OUTCOMES OF TREATMENT AND MANAGEMENT, 400 HYPERTENSIVE PATIENTS IN BONG SON GENERAL HOSPITAL, BINH DINH PROVINCE
    Hue University of Medicine and Pharmacy ; 2016
    In:  Journal of Medicine and Pharmacy
    Details
    In: Journal of Medicine and Pharmacy, Hue University of Medicine and Pharmacy
    Abstract: Objective: To evaluate the results of treatment achieved blood pressure goal (BP goal) and results of hypertensive patient management. Subjects and methods: A study of 400 hypertensive patient intervention, treatment and management after 2 year. To assess the results of BP target, monitor the use of medicines, the situation of hospitalization and complications of stroke. Results: Treatment: -100% of patients using diuretics and angiotensin-converting enzyme inhibitors (ACEIs), 33% of patients using angiotensin receptor blockers (ARBs), 46.25% of patients using calcium channel blockers (CCBs) and 19.5% of patients using beta-blocker. After 24 months of treatment: 50.5% of patients using 1 antihypertensive drug, 22% of patients using 2 drugs, 20.5% of patients using 3 drugs and 7% of patients taking more than 3 drugs. After 24 months of treatment: 91.75% achieved BP target and 8.25% fail. -Average risk stratification: 97.32% achieved BP target, hight risk stratification: 95.91% and very hight risk stratification: 73.03%. After 24 months of treatment. -Stage 1: 88.48% achieved BP target, stage 2: 92.85% achieved BP target and stage 3: 71.08% achieved BP target. After 24 months of treatment. -Hypertesive results before treatment were: 159.80 ± 20,22mmHg average systolic blood pressure and 82.97 ± 5,82mmHg average diastolic blood pressure. After treatment: average systolic blood pressure 125.38 ± 6,88mmHg and average diastolic blood pressure 79.83 ± 1,79mmHg. No adverse change in the index of tests about lipidemia, liver, kidney, glucomia and no recorded cases of drug side effects. Management of patients: -There were 89% non-medical examinational patients 1 month, 5.25% non-medical examinational patients 2 months, 4.25% non-medical examinational patients 3 months and 1.5% non-medical examinational patients 4 months. There were 93.5% drop pill 1 month, 3.25% drop pill 2 months, 4.25% drop pill 3 months and no patient drop pill over 3 months. In 24 months follow-up, 47% hospitalized inpatients 〈 5 times, 44.5% hospitalized inpatients 5-10 times, 3% hospitalized inpatients 11-15 times, 4.75% hospitalized inpatients from 16-20 times and 0.75% hospitalized inpatients 〉 20 times. -There were 32.75% hospitalized inpatients for reasons of hypertension and 63.75% hospitalized inpatients for other common diseases. -There were a total of 11592 contacts directly by phone for medical advice, medical reminders and examinational reminders during 24 months of management. -There were 0.5% of patients stroked during 24 months of treatment and management. Conclusion: Treatment by protocol and management by phone directly for medical taking and re-examinational reminders is the best resulted method of achieving blood pressure target and reducing complications of stroke for hypertensive patients. Key word: : blood pressure target; risk stratification; treatment; management; stage; phone.
    Type of Medium: Online Resource
    ISSN: 1859-3836
    URL: Journal
    URL: Article
    DOI: 10.34071/jmp
    DOI: 10.34071/jmp.2016.1.4
    Language: Vietnamese
    Publisher: Hue University of Medicine and Pharmacy
    Publication Date: 2016
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  • 10
    Online Resource
    Online Resource
    The agents of Sever Acute Respiratory Infection cases in Ben Tre province 2008-2010
    Springer Science and Business Media LLC ; 2011
    In:  BMC Proceedings Vol. 5, No. S1 ( 2011-12)
    Details
    In: BMC Proceedings, Springer Science and Business Media LLC, Vol. 5, No. S1 ( 2011-12)
    Type of Medium: Online Resource
    ISSN: 1753-6561
    URL: Article
    DOI: 10.1186/1753-6561-5-S1-P116
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2011
    detail.hit.zdb_id: 2411867-9
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