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  • 1
    In: The Lancet, Elsevier BV, Vol. 398, No. 10305 ( 2021-09), p. 1065-1073
    Type of Medium: Online Resource
    ISSN: 0140-6736
    RVK:
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2021
    detail.hit.zdb_id: 2067452-1
    detail.hit.zdb_id: 3306-6
    detail.hit.zdb_id: 1476593-7
    SSG: 5,21
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  • 2
    In: Annals of Hematology, Springer Science and Business Media LLC, Vol. 102, No. 10 ( 2023-10), p. 2741-2752
    Abstract: The approved dose of bosutinib in chronic phase CML is 400 mg QD in first-line and 500 mg QD in later-line treatment. However, given that gastrointestinal (GI) toxicity typically occurs early after treatment initiation, physicians often tend to start therapy with lower doses although this has never been tested systematically in prospective trials in the Western world. The Bo sutinib Do se Optimization (BODO) Study, a multicenter phase II study, investigated the tolerability and efficacy of a step-in dosing concept of bosutinib (starting at 300 mg QD) in chronic phase CML patients in 2 nd or 3 rd line who were intolerant and/or refractory to previous TKI treatment. Of 57 patients included until premature closure of the study due to slow recruitment, 34 (60%) reached the targeted dose level of 500 mg QD following the 2-weekly step-in dosing regimen. While the dosing-in concept failed to reduce GI toxicity (grade II–IV, primary study endpoint) to  〈  40% (overall rate of 60%; 95% CI: 45–74%), bosutinib treatment (mean dosage: 403 mg/day) showed remarkable efficacy with a cumulative major molecular remission (MMR) rate of 79% (95% CI: 66 to 88%) at month 24. Of thirty patients refractory to previous therapy and not in MMR at baseline, 19 (64%) achieved an MMR during treatment. GI toxicity did not significantly impact on patient-reported outcomes (PRO) and led to treatment discontinuation in only one patient. Overall, the results of our trial support the efficacy and safety of bosutinib after failure of second-generation TKI pre-treatment. Trial registration: NCT02577926.
    Type of Medium: Online Resource
    ISSN: 0939-5555 , 1432-0584
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1458429-3
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  • 3
    In: Arthritis Research & Therapy, Springer Science and Business Media LLC, Vol. 24, No. 1 ( 2022-11-22)
    Abstract: Current recommendations on the management of systemic sclerosis (SSc) suggest that autologous hematopoietic stem cell therapy (HSCT) can be a rescue therapy for patients with rapidly progressive SSc. Objectives To assess the safety and efficacy of HSCT for patients with SSc and to compare these with non-HSCT patients in a control cohort with adjusted risk factors. Methods A retrospective analysis of data from the multicentric German network for systemic scleroderma (DNSS) with 5000 patients with SSc. Control groups consisted of all patients with diffuse cutaneous (dc)-SSc (group A) and an adjusted high-risk cohort of male patients with Scl70-positive dc-SSc (group B). Results Eighty SSc patients received an HSCT 4.1 ± 4.8 years after SSc diagnosis. Among them, 86.3% had dc-SSc, 43.5% were males, and 71.3% were positive for Scl70 antibodies. The control group A ( n =1513) showed a significant underrepresentation of these risk factors for mortality. When the survival of the control group B ( n =240) was compared with the HSCT group, a lower mortality of the latter was observed instead. Within 5 years after HSCT, we observed an improvement of the mRSS from 17.6 ± 11.5 to 11.0 ± 8.5 ( p =0.001) and a stabilization of the DLCO. We did not see differences in transplant-related mortality between patients who received HSCT within 3 years after SSc diagnosis or later. Conclusion Our analysis of real-life data show that the distribution of risk factors for mortality is critical when HSCT cohorts are compared with non-HSCT control groups.
    Type of Medium: Online Resource
    ISSN: 1478-6362
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2041668-4
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  • 4
    Online Resource
    Online Resource
    SAGE Publications ; 2000
    In:  Personality and Social Psychology Bulletin Vol. 26, No. 9 ( 2000-11), p. 1142-1150
    In: Personality and Social Psychology Bulletin, SAGE Publications, Vol. 26, No. 9 ( 2000-11), p. 1142-1150
    Abstract: Anchoring effects—the assimilation of a numeric estimate to a previously considered standard—have proved to be remarkably robust. Results of two studies, however, demonstrate that anchoring can be reduced by applying a consider-the-opposite strategy. Based on the Selective Accessibility Model, which assumes that anchoring is mediated by the selectively increased accessibility of anchor-consistent knowledge, the authors hypothesized that increasing the accessibility of anchor-inconsistent knowledge mitigates the effect. Considering the opposite (i.e., generating reasons why an anchor is inappropriate) fulfills this objective and consequently proves to be a successful corrective strategy. In a real-world setting using experts as participants, Study 1 dem-onstrated that listing arguments that speak against a provided anchor value reduces the effect. Study 2 further revealed that the effects of anchoring and considering the opposite are additive.
    Type of Medium: Online Resource
    ISSN: 0146-1672 , 1552-7433
    RVK:
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2000
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    SSG: 5,2
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  • 5
    Online Resource
    Online Resource
    S. Karger AG ; 2005
    In:  Verhaltenstherapie Vol. 15, No. 1 ( 2005), p. 20-26
    In: Verhaltenstherapie, S. Karger AG, Vol. 15, No. 1 ( 2005), p. 20-26
    Type of Medium: Online Resource
    ISSN: 1016-6262 , 1423-0402
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2005
    detail.hit.zdb_id: 1483583-6
    SSG: 5,2
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  • 6
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2017
    In:  Journal of Strength and Conditioning Research Vol. 31, No. 3 ( 2017-03), p. 608-619
    In: Journal of Strength and Conditioning Research, Ovid Technologies (Wolters Kluwer Health), Vol. 31, No. 3 ( 2017-03), p. 608-619
    Abstract: Julian, R, Meyer, T, Fullagar, HHK, Skorski, S, Pfeiffer, M, Kellmann, M, Ferrauti, A, and Hecksteden, A. Individual patterns in blood-borne indicators of fatigue—trait or chance. J Strength Cond Res 31(3): 608–619, 2017—Blood-borne markers of fatigue such as creatine kinase (CK) and urea (U) are widely used to fine-tune training recommendations. However, predictive accuracy is low. A possible explanation for this dissatisfactory characteristic is the propensity of athletes to react to different patterns of fatigue indicators (e.g., predominantly muscular [CK] or metabolic [U] ). The aim of the present trial was to explore this hypothesis by using repetitive fatigue-recovery cycles. A total of 22 elite junior swimmers and triathletes (18 ± 3 years) were monitored for 9 weeks throughout 2 training phases (low-intensity, high-volume [LIHV] and high-intensity, low-volume [HILV] phases). Blood samples were collected each Monday (recovered) and Friday (fatigued) morning. From measured values of CK, U, free-testosterone (FT), and cortisol (C) as determined in the rested and fatigued state, respectively, Monday–Friday differences (Δ) were calculated and classified by magnitude before calculation of ratios (ΔCK/ΔU and ΔFT/ΔC). Coefficient of variation (CV) was calculated as group-based estimate s of reproducibility. Linear mixed modeling was used to differentiate inter- and intraindividual variability. Consistency of patterns was analyzed by comparing with threshold values ( 〈 0.9 or 〉 1.1 for all weeks). Reproducibility was very low for fatigue-induced changes (CV ≥ 100%) with interindividual variation accounting for 45–60% of overall variability. Case-wise analysis indicated consistent ΔCK/ΔU patterns for 7 individuals in LIHV and 7 in HILV; 5 responded consistently throughout. For ΔFT/ΔC the number of consistent patterns was 2 in LIHV and 3 in HILV. These findings highlight the potential value of an individualized and multivariate approach in the assessment of fatigue.
    Type of Medium: Online Resource
    ISSN: 1064-8011
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
    detail.hit.zdb_id: 2142889-X
    SSG: 31
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  • 7
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Journal of Strength and Conditioning Research Vol. 30, No. 12 ( 2016-12), p. 3412-3427
    In: Journal of Strength and Conditioning Research, Ovid Technologies (Wolters Kluwer Health), Vol. 30, No. 12 ( 2016-12), p. 3412-3427
    Abstract: Raeder, C, Wiewelhove, T, Simola, RÁDP, Kellmann, M, Meyer, T, Pfeiffer, M, and Ferrauti, A. Assessment of fatigue and recovery in male and female athletes after 6 days of intensified strength training. J Strength Cond Res 30(12): 3412–3427, 2016—This study aimed to analyze changes of neuromuscular, physiological, and perceptual markers for routine assessment of fatigue and recovery in high-resistance strength training. Fourteen male and 9 female athletes participated in a 6-day intensified strength training microcycle (STM) designed to purposefully overreach. Maximal dynamic strength (estimated 1 repetition maximum [1RM est ]; criterion measure of fatigue and recovery); maximal voluntary isometric strength (MVIC); countermovement jump (CMJ) height; multiple rebound jump (MRJ) height; jump efficiency (reactive strength index, RSI); muscle contractile properties using tensiomyography including muscle displacement (Dm), delay time (Td), contraction time (Tc), and contraction velocity (V90); serum concentration of creatine kinase (CK); perceived muscle soreness (delayed-onset muscle soreness, DOMS) and perceived recovery (physical performance capability, PPC); and stress (MS) were measured before and after the STM and after 3 days of recovery. After completing the STM, there were significant ( p ≤ 0.05) performance decreases in 1RM est (%∆ ± 90% confidence limits, ES = effect size; −7.5 ± 3.5, ES = −0.21), MVIC (−8.2 ± 4.9, ES = −0.24), CMJ (−6.4 ± 2.1, ES = −0.34), MRJ (−10.5 ± 3.3, ES = −0.66), and RSI (−11.2 ± 3.8, ES = −0.73), as well as significantly reduced muscle contractile properties (Dm, −14.5 ± 5.3, ES = −0.60; V90, −15.5 ± 4.9, ES = −0.62). After days of recovery, a significant return to baseline values could be observed in 1RM est (4.3 ± 2.8, ES = 0.12), CMJ (5.2 ± 2.2, ES = 0.28), and MRJ (4.9 ± 3.8, ES = 0.32), whereas RSI (−7.9 ± 4.5, ES = −0.50), Dm (−14.7 ± 4.8, ES = −0.61), and V90 (−15.3 ± 4.7, ES = −0.66) remained significantly reduced. The STM also induced significant changes of large practical relevance in CK, DOMS, PPC, and MS before to after training and after the recovery period. The markers Td and Tc remained unaffected throughout the STM. Moreover, the accuracy of selected markers for assessment of fatigue and recovery in relation to 1RM est derived from a contingency table was inadequate. Correlational analyses also revealed no significant relationships between changes in 1RM est and all analyzed markers. In conclusion, mean changes of performance markers and CK, DOMS, PPC, and MS may be attributed to STM-induced fatigue and subsequent recovery. However, given the insufficient accuracy of markers for differentiation between fatigue and recovery, their potential applicability needs to be confirmed at the individual level.
    Type of Medium: Online Resource
    ISSN: 1064-8011
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
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    SSG: 31
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  • 8
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2017
    In:  Journal of Strength and Conditioning Research Vol. 31, No. 6 ( 2017-06), p. 1569-1576
    In: Journal of Strength and Conditioning Research, Ovid Technologies (Wolters Kluwer Health), Vol. 31, No. 6 ( 2017-06), p. 1569-1576
    Abstract: Schimpchen, J, Wagner, M, Ferrauti, A, Kellmann, M, Pfeiffer, M, and Meyer, T. Can cold water immersion enhance recovery in elite Olympic weightlifters? An individualized perspective. J Strength Cond Res 31(6): 1569–1576, 2017—We investigated whether cold water immersion (CWI) after intensive training sessions can enhance recovery in elite Olympic weightlifters, taking into account each athlete's individual response pattern. The entire German male Olympic weightlifting national team participated in the study ( n = 7), ensuring collection of data from elite athletes only. Using a randomized cross-over design, the athletes went through 2 high-intensity training microcycles consisting of 5 training sessions that were either followed by a CWI or passive recovery. Barbell speed in a snatch pull movement, blood parameters, and subjective ratings of general fatigue and recovery were assessed throughout the study. Physical performance at 2 snatch pull intensities (85% one repetition maximum [1RM]: −0.15% vs. −0.22%, p = 0.94; 90% 1RM: −0.7% vs. +1.23%, p = 0.25) did not differ significantly (condition × time). Although questionnaires revealed a significant decline in the ratings of overall recovery ( p 〈 0.001) and a significantly higher rating of overall stress ( p = 0.03) over time, no significant differences between conditions ( p = 0.14; p = 0.98) could be revealed. Similarly, neither of the analyzed blood parameters changed significantly between conditions over time (creatine kinase: p = 0.53; urea: p = 0.43; cortisol: p = 0.59; testosterone: p = 0.53; testosterone:cortisol ratio: p = 0.69). In general, CWI did not prove to be an effective tool to enhance recovery in elite Olympic weightlifters over a 3-day intensive training period. However, even though the group was rather homogeneous with regard to performance, there were considerable intersubject differences in their response to CWI. It seems that athletes are best advised on a case-by-case basis.
    Type of Medium: Online Resource
    ISSN: 1064-8011
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
    detail.hit.zdb_id: 2142889-X
    SSG: 31
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  • 9
    Online Resource
    Online Resource
    International Union of Crystallography (IUCr) ; 2002
    In:  Journal of Applied Crystallography Vol. 35, No. 4 ( 2002-08-01), p. 430-433
    In: Journal of Applied Crystallography, International Union of Crystallography (IUCr), Vol. 35, No. 4 ( 2002-08-01), p. 430-433
    Abstract: The internal reflection of an excited X-ray waveguide mode in a synthetic nanostructure, defined by electron-beam lithography, has been measured. In this device, the X-ray beam is first coupled into a conventional vertical thin-film waveguide structure and then reflected laterally at the quasi-one-dimensional edge of the waveguiding layer. The reflectivity of the quasi-one-dimensional interface has been recorded under simultaneous excitation of the (vertical) waveguide mode. The experiment constitutes an important step towards the production of a coherent nanometre-sized X-ray point source by two-dimensionally defined waveguide structures.
    Type of Medium: Online Resource
    ISSN: 0021-8898
    RVK:
    Language: Unknown
    Publisher: International Union of Crystallography (IUCr)
    Publication Date: 2002
    detail.hit.zdb_id: 2020879-0
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  • 10
    Online Resource
    Online Resource
    International Union of Crystallography (IUCr) ; 2009
    In:  Acta Crystallographica Section A Foundations of Crystallography Vol. 65, No. a1 ( 2009-08-16), p. s74-s74
    In: Acta Crystallographica Section A Foundations of Crystallography, International Union of Crystallography (IUCr), Vol. 65, No. a1 ( 2009-08-16), p. s74-s74
    Type of Medium: Online Resource
    ISSN: 0108-7673
    Language: Unknown
    Publisher: International Union of Crystallography (IUCr)
    Publication Date: 2009
    detail.hit.zdb_id: 2020844-3
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