In:
Molbank, MDPI AG, Vol. 2023, No. 1 ( 2023-01-13), p. M1552-
Abstract:
3-(3,4-Dichlorophenyl)-5-(1H-indol-5-yl)-1,2,4-oxadiazole was synthesized via the condensation of 3,4-dichlorobenzamidoxime and methyl 1H-indole-5-carboxylate using a superbasic medium (NaOH/DMSO). The compound was tested as a potential inhibitor of human monoamine oxidase (MAO) A and B. It demonstrated a notable inhibition with an IC50 value of 0.036 μM for the MAO-B and isoform specificity. The product was characterized by 1H-NMR, 13C-NMR, and HRMS. In conclusion, the new active MAO-B inhibitor may serve as a candidate for the future discovery of therapeutic agents for neurodegenerative disorders such as Parkinson’s disease.
Type of Medium:
Online Resource
ISSN:
1422-8599
Language:
English
Publisher:
MDPI AG
Publication Date:
2023
detail.hit.zdb_id:
2170280-9
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