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  • 1
    Online Resource
    Online Resource
    A Prospective Head-to-Head Comparison of 18F-Fluciclovine With 68Ga-PSMA-11 in Biochemical Recurrence of Prostate Cancer in PET/CT
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  Clinical Nuclear Medicine Vol. 44, No. 10 ( 2019-10), p. e566-e573
    Details
    In: Clinical Nuclear Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 44, No. 10 ( 2019-10), p. e566-e573
    Abstract: One of the major challenges for all imaging modalities is accurate detection of prostate cancer (PCa) recurrence. Beyond the established 68 Ga-PSMA, a novel promising PET tracer in PCa imaging is 18 F-fluciclovine. For evaluating the advantages and disadvantages and the comparability, we conducted a prospective head-to-head comparison on 18 F-fluciclovine and 68 Ga-PSMA-11 in patients with biochemical recurrence of PCa. Methods 58 patients with biochemical recurrence of PCa after definitive primary therapy were included. Both scans were performed within a time window of mean 9.4 days. All scans were visually analyzed independently on a patient-, region- and lesion-based analysis. All the examinations were performed in the same medical department using identical scanners at any time. Results The overall detection rate for PCa recurrence was 79.3% in 18 F-fluciclovine and 82.8% in 68 Ga-PSMA-11 ( P = 0.64). Local recurrence was detected in 37.9% on 18 F-fluciclovine and in 27.6% on 68 Ga-PSMA-11 ( P = 0.03). Local pelvic lymph node recurrence was detected on 18 F-fluciclovine versus 68 Ga-PSMA-11 in 46.6% versus 50%, in extrapelvic lymph node metastases in 41.4% versus 51.7% and in bone metastases in 25.9% versus 36.2%. Lesion-based analysis showed identical findings in local pelvic lymph nodes in 39.7%, in extrapelvic lymph nodes in 22.4%, and in bone metastases in 13.8%. Conclusions The advantage of 18 F-fluciclovine is detecting curable localized disease in close anatomical relation to the urinary bladder, whereas 68 Ga-PSMA-11 fails because of accumulation of activity in the urinary bladder. 18 F-fluciclovine is almost equivalent to 68 Ga-PSMA-11 in detecting distant metastases of PCa recurrence.
    Type of Medium: Online Resource
    ISSN: 1536-0229 , 0363-9762
    URL: Article
    DOI: 10.1097/RLU.0000000000002703
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2045053-9
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  • 2
    Online Resource
    Online Resource
    Diagnostic and prognostic value of additional SPECT/CT in sentinel lymph node mapping in breast cancer patients
    Georg Thieme Verlag KG ; 2018
    In:  Nuklearmedizin - NuclearMedicine Vol. 57, No. 03 ( 2018-06), p. 92-99
    Details
    In: Nuklearmedizin - NuclearMedicine, Georg Thieme Verlag KG, Vol. 57, No. 03 ( 2018-06), p. 92-99
    Abstract: The aim of the study was to demonstrate the diagnostic and prognostic value of SPECT/CT in sentinel lymph node mapping (SLNM) in patients with invasive breast cancer. Methods: 114 patients with invasive breast cancer with clinically negative lymph nodes were included in this retrospective study as they were referred for SLNM with 99mTc-nanocolloid. Planar image acquisition was accomplished in a one-day or two-day protocol depending on the schedule of the surgical procedure. Low dose SPECT/CT was performed after the planar images. The sentinel lymph node biopsy (SLNB) was considered false negative if a primary recurrence developed within 12 months after SLNB in the axilla from which a tumor-free SLN had been removed. Results: Between December 2009 and December 2011, 114 patients (pts.) underwent SLNM with additional SPECT/CT. Planar imaging identified in 109 pts. 139 SLNs, which were tumor-positive in 42 nodes (n = 41 pts.). SPECT/CT identified in 81 pts. 151 additional SLNs, of which 19 were tumor-positive and led to therapy change (axillary lymph node dissection) in 11 pts. (9.6 %). Of overall 61 tumor-positive SLNs (n = 52 pts.) SPECT/CT detected all, whereas planar imaging detected only 42 of 61 (P 〈 0.0001). No patient had lymph node metastasis within 12 months after SLNB in the axilla from which a tumor-free SLN had been removed resulting in a false-negative rate of 0 %. The local relapse rate was 1.8 % leading to a 4-year disease-free survival rate of 90 %. Conclusion: Among patients with breast cancer, the use of SPECT/CT-aided SLNM correlated due to a better anatomical localization and identification of planar not visible SLNs with a higher detection rate of SLNs. This led to therapeutic consequences and an excellent false-negative and 4-year disease-free survival rate.
    Type of Medium: Online Resource
    ISSN: 0029-5566 , 2567-6407
    URL: Article
    DOI: 10.3413/Nukmed-0929-17-09
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2018
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  • 3
    Online Resource
    Online Resource
    F18-FDG PET/CT in a patient with Antisynthetase Syndrome
    Georg Thieme Verlag KG ; 2023
    In:  Nuklearmedizin - NuclearMedicine Vol. 62, No. 02 ( 2023-04), p. 73-74
    Details
    In: Nuklearmedizin - NuclearMedicine, Georg Thieme Verlag KG, Vol. 62, No. 02 ( 2023-04), p. 73-74
    Abstract: More prevalent in women than men, Antisynthetase Syndrome is a rare and poorly defined autoimmune disease associated with interstitial lung disease, polymyositis, and dermatomyositis. In addition to various diagnostic tools, imaging modalities are needed in certain situations. A 42-year-old woman with Anti-Jo-1-positive Antisynthetase Syndrome presented with thoracic muscular pain. She underwent whole-body Fluorodeoxyglucose positron emission tomography/computed tomography (F18-FDG PET/CT) to evaluate the total extent of the muscles affected. Depicting symptomatic symmetric myositis of the intercostal muscles, F18-FDG PET/CT additionally revealed unusually extensive fasciitis of the lower extremities.
    Type of Medium: Online Resource
    ISSN: 0029-5566 , 2567-6407
    URL: Article
    DOI: 10.1055/a-1996-0157
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2023
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  • 4
    Online Resource
    Online Resource
    Lymphoscintigraphy for Sentinel Lymph Node Biopsy in Breast Cancer: Do We Need a Delayed Image?
    S. Karger AG ; 2020
    In:  Breast Care Vol. 15, No. 1 ( 2020), p. 55-59
    Details
    In: Breast Care, S. Karger AG, Vol. 15, No. 1 ( 2020), p. 55-59
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Sentinel lymph node biopsy has become a standard of care in the treatment of patients with early breast cancer, but clinical guidelines continue to be vague on details of the procedure. We were interested in the results of our 2-day protocol, which includes delayed lymphoscintigraphy at 18 h. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We reviewed the results of preoperative lymphoscintigrams in patients undergoing surgery for breast cancer. Lymphoscintigraphy was performed 2 h after periareolar injection of 4 × 37 MBq 〈 sup 〉 99m 〈 /sup 〉 Tc nanocolloid (early lymphoscintigraphy) and 18 h following injection (delayed lymphoscintigraphy). The early results were compared with the late results. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A total of 238 lymphoscintigraphies were performed in 232 patients (6 bilateral). At 2 h, ≥1 sentinel nodes were visualized in 154/238 (65%) cases; in 84 (35%), no sentinel node was visualized. Delayed lymphoscintigraphy visualized a sentinel node in 40 of 76 (53%) cases with no visualization at 2 h and failed to show a sentinel node in 36 (47%) of these cases (in 8 cases, no delayed lymphoscintigram was obtained). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Delayed lymphoscintigraphy was useful in about 50% of the breast cancer patients in whom immediate scintigraphy failed to demonstrate a sentinel lymph node.
    Type of Medium: Online Resource
    ISSN: 1661-3791 , 1661-3805
    URL: Article
    DOI: 10.1159/000496504
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2020
    detail.hit.zdb_id: 2205941-6
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  • 5
    Online Resource
    Online Resource
    Dopamine-1-receptor stimulation and mucosal tissue oxygenation in the porcine jejunum
    Ovid Technologies (Wolters Kluwer Health) ; 1995
    In:  Critical Care Medicine Vol. 23, No. 9 ( 1995-09), p. 1560-1566
    Details
    In: Critical Care Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 23, No. 9 ( 1995-09), p. 1560-1566
    Type of Medium: Online Resource
    ISSN: 0090-3493
    URL: Article
    DOI: 10.1097/00003246-199509000-00017
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 1995
    detail.hit.zdb_id: 2034247-0
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  • 6
    Online Resource
    Online Resource
    Diagnostic value of two-time point [68Ga]Ga-PSMA-11 PET/CT in the primary staging of untreated prostate cancer
    Springer Science and Business Media LLC ; 2023
    In:  Scientific Reports Vol. 13, No. 1 ( 2023-05-22)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-05-22)
    Abstract: The emerging PET tracer [ 68 Ga]Ga-PSMA-11 has been established for staging in prostate cancer (PCa). Aim was to determine the value of early static imaging in two-phase PET/CT. 100 men with newly diagnosed histopathologically confirmed untreated PCa who underwent [ 68 Ga]Ga-PSMA-11 PET/CT from January 2017 to October 2019 were included. The two-phase imaging protocol consisted of an early static scan of the pelvis (6 min p.i.) and a late total-body scan (60 min p.i). Associations of semi-quantitative parameters derived via volumes of interest (VOI) with Gleason grade group and PSA were investigated. In 94/100 patients (94%) the primary tumor was detected in both phases. In 29/100 patients (29%) metastases were detected at a median PSA level of 32.2 ng/ml (0.41–503 ng/ml). In 71/100 patients (71%) without metastasis a median PSA level of 10.1 ng/ml (0.57–103 ng/ml) was observed ( p  =  〈  0.001). Primary tumors demonstrated a median standard uptake value maximum (SUVmax) of 8.2 (3.1–45.3) in early phase versus 12.2 (3.1–73.4) in late phase and a median standard uptake value mean (SUVmean) of 4.2 (1.6–24.1) in early phase versus 5.8 (1.6–39.9) in late phase, significantly increasing over time ( p  =  〈  0.001). Higher SUVmax and SUVmean were associated with higher Gleason grade group ( p  = 0.004 and p  = 0.003, respectively) and higher PSA levels ( p  =  〈  0.001). In 13/100 patients the semi-quantitative parameters including SUVmax were declining in the late phase compared to early phase. Two-phase [ 68 Ga]Ga-PSMA-11 PET/CT demonstrates a high detection rate for primary tumor of untreated PCa of 94% and improves diagnostic accuracy. Higher PSA levels and Gleason grade group are associated with higher semi-quantitative parameters in the primary tumor. Early imaging provides additional information in a small sub-group with declining semi-quantitative parameters in the late phase.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-023-35628-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2615211-3
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  • 7
    Online Resource
    Online Resource
    Oligodendroglioma in 68Ga-PSMA-11 and 18F-Fluciclovine PET/CT
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Clinical Nuclear Medicine Vol. 46, No. 4 ( 2021-4), p. e231-e232
    Details
    In: Clinical Nuclear Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 46, No. 4 ( 2021-4), p. e231-e232
    Abstract: Prostate cancer (PC) is one of the most common cancers affecting men worldwide, with a high recurrence rate after therapy. 68 Ga-PSMA-11 and 18 F-fluciclovine are PET imaging tracers for the detection of recurrence sites in PC patients. 68 Ga-PSMA-11 is a membrane antigen overexpressed by tumor cells, whereas 18 F-fluciclovine targets increased amino acid transporter in the membrane of cancer cells. We report a case of an 83-year-old man with known oligodendroglioma and biochemically recurrent PC who shows a high focal 68 Ga-PSMA-11 and 18 F-fluciclovine uptake in the brain.
    Type of Medium: Online Resource
    ISSN: 1536-0229 , 0363-9762
    URL: Article
    DOI: 10.1097/RLU.0000000000003347
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
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  • 8
    Online Resource
    Online Resource
    18F-FDG PET/CT in the Hyperparathyroidism–Jaw-Tumor Syndrome
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Clinical Nuclear Medicine Vol. 46, No. 6 ( 2021-6), p. 497-498
    Details
    In: Clinical Nuclear Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 46, No. 6 ( 2021-6), p. 497-498
    Abstract: Hyperparathyroidism–jaw-tumor syndrome (HPT-JTS) is a rare autosomal dominant disorder. A typical manifestation of HPT-JTS is the association of jaw-ossifying fibroma with primary hyperparathyroidism. Due to its rarity and diversity in its manifestations, it is a challenging diagnosis. A 33-year-old woman was referred due to painful swelling of the right maxilla suggestive of malignancy. The clinical presentations were not conclusive until she underwent F18-fluorodeoxyglucose positron emission tomography/computed tomography (F18-FDG PET/CT). F18-FDG PET/CT proved to be a useful tool to assist the clinicians in visualizing the “bigger picture” and, therefore all manifestation as pieces of “one puzzle.”
    Type of Medium: Online Resource
    ISSN: 1536-0229 , 0363-9762
    URL: Article
    DOI: 10.1097/RLU.0000000000003625
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2045053-9
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  • 9
    Online Resource
    Online Resource
    Short-term changes of protozoan control on autotrophic picoplankton in an oligo-mesotrophic lake
    Oxford University Press (OUP) ; 1996
    In:  Journal of Plankton Research Vol. 18, No. 3 ( 1996), p. 443-462
    Details
    In: Journal of Plankton Research, Oxford University Press (OUP), Vol. 18, No. 3 ( 1996), p. 443-462
    Type of Medium: Online Resource
    ISSN: 0142-7873 , 1464-3774
    URL: Article
    DOI: 10.1093/plankt/18.3.443
    Language: English
    Publisher: Oxford University Press (OUP)
    Publication Date: 1996
    detail.hit.zdb_id: 756271-8
    detail.hit.zdb_id: 1474909-9
    SSG: 12
    SSG: 21,3
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  • 10
    Online Resource
    Online Resource
    Different Appearances of 3 Malignancies in 68Ga-PSMA-11 Versus 18F-FDG PET/CT
    Ovid Technologies (Wolters Kluwer Health) ; 2021
    In:  Clinical Nuclear Medicine Vol. 46, No. 7 ( 2021-7), p. e358-e359
    Details
    In: Clinical Nuclear Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 46, No. 7 ( 2021-7), p. e358-e359
    Abstract: Prostate-specific membrane antigen (PSMA) overexpression has been described in various malignancies. Hereby we present a case of a 69-year-old man simultaneously diagnosed with prostate cancer, esophageal adenocarcinoma, and HCC (hepatocellular carcinoma). 18 F-FDG PET/CT showed pathological uptake in the esophageal adenocarcinoma and the primary prostate tumor, whereas 68 Ga-PSMA-11 PET/CT performed for staging of the histopathologically confirmed prostate cancer revealed the primary tumor and significant uptake in the HCC. This finding is remarkable because the high physiological liver uptake of 68 Ga-PSMA-11 may hamper the detection of small lesions.
    Type of Medium: Online Resource
    ISSN: 1536-0229 , 0363-9762
    URL: Article
    DOI: 10.1097/RLU.0000000000003538
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2021
    detail.hit.zdb_id: 2045053-9
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