In:
Science Translational Medicine, American Association for the Advancement of Science (AAAS), Vol. 14, No. 643 ( 2022-05-04)
Abstract:
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and is one of the leading causes of death from a single infectious agent. Ethionamide is a prodrug used to treat multidrug resistant TB. MymA is a mycobacterial oxidase that is responsible for the activation of ethionamide. The production of MymA is under the control of the transcriptional regulator VirS. Flipo et al. now report the discovery of the small-molecule SMARt751, a VirS ligand that up-regulates expression of the mymA operon. SMARt751 reversed resistance to ethionamide in mouse models of acute and chronic TB.
Type of Medium:
Online Resource
ISSN:
1946-6234
,
1946-6242
DOI:
10.1126/scitranslmed.aaz6280
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2022
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