In:
Mersin Üniversitesi Sağlık Bilimleri Dergisi, Mersin Universitesi Saglik Bilimleri Dergisi, Vol. 15, No. 1 ( 2022-04-30), p. 50-55
Kurzfassung:
Aim: Many new agents have started to take place in the management of patients with chronic lymphocytic leukemia in recent years. Following the antibodies developed against CD20 and the new targeting molecules such as ibrutinib, idelalisib and venetoclax, treatment algorithms have changed rapidly. In this study, it was aimed to determine chronic lymphocytic leukemia treatment approaches in our center before the coronavirus pandemic. Method: Patients who were followed up with a diagnosis of chronic lymphocytic leukemia between October 01, 2018 and December 31, 2019 were analyzed retrospectively in our center. All adult patients aged 18 years and over, whose follow-up and treatment data were available, were included in the study. Patients, whose diagnosis was not confirmed, treatment was initiated before the study interval and who were followed at an external center, were excluded. All data were gathered from the electronic database used for patient follow-up in our hospital. Results: A total of 138 (85 men, 53 women) patients were included in the study. The mean age of the cases was 65 (35-88) years. Further analyzes were made for 28 cases who received treatment. Among these patients, 64% received first-line treatment, while 32% were treated for relapse/refractory disease. The most common protocols used in the first line were bendamustine, rituximab (39%) and fludarabine, cyclophosphamide, rituximab (33%). Considering relapsed /refractory disease ibrutinib (%78) and venetoclax (22%) were the drugs used. Conclusion: It was observed that a chemoimmunotherapy protocol containing rituximab was primarily preferred in the first line treatment of chronic lymphocytic leukemia and targeted new molecules were applied in all relapsed/refractory patients. Our algorithms were in line with the current guidelines. As the new molecules were preferred in all patients with suitable reimbursement conditions, we think that targeted molecules will replace chemotherapy in further time.
Materialart:
Online-Ressource
ISSN:
1308-0830
DOI:
10.26559/mersinsbd.962931
Sprache:
Unbekannt
Verlag:
Mersin Universitesi Saglik Bilimleri Dergisi
Publikationsdatum:
2022
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