In:
Hepatology, Ovid Technologies (Wolters Kluwer Health), Vol. 66, No. 1 ( 2017-07), p. 198-208
Abstract:
Screening for hepatic encephalopathy (HE) that does not cause obvious disorientation or asterixis (minimal HE [MHE]/grade 1 HE) is important. We examined if the animal naming test (ANT 1 ) (maximum number of animals listed in 1 minute) is useful in this context. In total, 208 healthy controls, 40 controls with inflammatory bowel disease, and 327 consecutive patients with cirrhosis underwent the ANT 1 . Patients were tested for MHE by the psychometric HE score, and 146 were assessed by electroencephalography; 202 patients were followed up regarding the occurrence of overt HE and death. In the healthy controls, ANT 1 was influenced by limited education ( 〈 8 years) and advanced age ( 〉 80 years, P 〈 0.001). Using an age and education adjusting procedure, the simplified ANT 1 (S‐ANT 1 ) was obtained. An S‐ANT 1 of 〈 10 animals was abnormal. Of the patients, 169 were considered unimpaired, 32 as having HE ≥grade 2, and 126 as having MHE/grade 1 HE. This group had lower S‐ANT 1 than unimpaired patients (12 ± 0.4 versus 16 ± 0.7, P 〈 0.001) and higher S‐ANT 1 than those with HE ≥grade 2 (4 ± 0.9). In grade 1 HE the S‐ANT 1 was lower than in MHE. Following receiver operating characteristic analysis (Youden's index), 15 animals produced the best discrimination between unimpaired and MHE/grade 1 HE patients. Thus, a three‐level score (0 for S‐ANT 1 ≥15, 1 for 10 ≤ S‐ANT 1 〈 15, 2 for S‐ANT 1 〈 10) was obtained. This score was correlated both to the psychometric HE score ( P 〈 0.0001) and to electroencephalography ( P = 0.007). By sample random split validation, both S‐ANT 1 and its three‐level score showed prognostic value regarding the 1‐year risk of overt HE and death. No inflammatory bowel disease control had S‐ANT 〈 15. Conclusion : The S‐ANT 1 is an easily obtainable measure useful for the assessment of HE. (H epatology 2017;66:198–208).
Type of Medium:
Online Resource
ISSN:
0270-9139
,
1527-3350
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2017
detail.hit.zdb_id:
1472120-X
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