In:
Chemotherapy, S. Karger AG, Vol. 46, No. 6 ( 2000), p. 395-401
Abstract:
〈 i 〉 Background: 〈 /i 〉 〈 i 〉 Candida dubliniensis 〈 /i 〉 is a recently described 〈 i 〉 Candida 〈 /i 〉 species closely related to 〈 i 〉 Candida albicans 〈 /i 〉 , which has been associated with oral candidiasis in HIV-infected patients. Fluconazole-resistant strains of 〈 i 〉 C. dubliniensis 〈 /i 〉 are easily obtained in vitro and this fact could be a complication if this resistance develops during treatment with this drug. 〈 i 〉 Methods: 〈 /i 〉 In the present study, the in vitro antifungal susceptibilities of 36 〈 i 〉 C. dubliniensis 〈 /i 〉 clinical isolates and culture strains to current and new antifungal agents, such as amphotericin B (AMB), amphotericin B lipid complex (ABLC), amphotericin B colloidal dispersion (ABCD), 5-fluorocytosine (5FC), fluconazole (FLC), itraconazole (ITC), ketoconazole (KTC), liposomal amphoteri- cin B (LAMB), liposomal nystatin (LNYT), LY303366 (LY), SCH56592 (SCH), and voriconazole (VRC), were determined according to the National Committee for Clinical Laboratory Standards M27-A broth microdilution method for yeasts. 〈 i 〉 Results: 〈 /i 〉 Most isolates of 〈 i 〉 C. dubliniensis 〈 /i 〉 were susceptible to both new and current antifungal drugs, with 75.9% isolates susceptible to KTC, 86.2% to FLC and to ITC, and ∼100% to the other antifungal agents tested. The cross-resistance phenotypes are detailed. Four isolates were resistant (MIC ≥64 μg/ml) to FLC. These 4 isolates were also resistant to KTC, and 3 of them were also resistant to ITC (MIC ≥1 μg/ml for both agents). However, these isolates were highly susceptible to 5FC and all polyene formulations (AMB, ABLC, ABCD, LAMB, and LNYT), triazole (SCH and VRC) and echinocandin (LY) antifungal agents. 〈 i 〉 Conclusion: 〈 /i 〉 The new liposomal and lipidic formulations of AMB, LNYT, and the new triazoles and echinocandins may provide new alternatives to FLC for the treatment of infections by 〈 i 〉 C. dubliniensis 〈 /i 〉 .
Type of Medium:
Online Resource
ISSN:
0009-3157
,
1421-9794
Language:
English
Publisher:
S. Karger AG
Publication Date:
2000
detail.hit.zdb_id:
1482111-4
SSG:
15,3
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