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  • 1
    Online Resource
    Online Resource
    Epidemiology of Helicobacter pylori infection
    Wiley ; 2018
    In:  Helicobacter Vol. 23, No. S1 ( 2018-09)
    Details
    In: Helicobacter, Wiley, Vol. 23, No. S1 ( 2018-09)
    Abstract: This review provides the most recent data concerning the epidemiology of Helicobacter pylori infection. Overall, the trend of declining prevalence of H. pylori infection is continuing, with major evidence available from studies in Europe. However, in some parts of the world, for example, in some countries in the Middle East, the prevalence has remained relatively stable. A number of systematic reviews and meta‐analyses have been published during the past year indicating the lowest prevalence rates of the infection in Oceania (24.4%), the highest in Africa (79.1%), and the global annual recurrence rate of H. pylori (4.3%). The recurrence rates were found to be directly related to the human development index and prevalence of infection. Several studies have addressed the correlation between H. pylori infection and sociodemographic conditions, source of drinking water and dietary factors. A hypothesis on the role of insects and yeasts in transmitting H. pylori has been suggested and addressed. Helicobacter sp. have been found in flow flies in Brazil. So far there is no evidence available that H. pylori may survive and persist on the outer body of the fly.
    Type of Medium: Online Resource
    ISSN: 1083-4389 , 1523-5378
    URL: Issue
    URL: Article
    DOI: 10.1111/hel.2018.23.issue-S1
    DOI: 10.1111/hel.12514
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2020336-6
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Pepsinogen Test for the Evaluation of Precancerous Changes in Gastric Mucosa: a Population-Based Study
    Romanian Society of Gastroenterology and Hepatology ; 2018
    In:  Journal of Gastrointestinal and Liver Diseases Vol. 27, No. 1 ( 2018-03-31), p. 11-17
    Details
    In: Journal of Gastrointestinal and Liver Diseases, Romanian Society of Gastroenterology and Hepatology, Vol. 27, No. 1 ( 2018-03-31), p. 11-17
    Abstract: Aims: The aim of the study was to evaluate the rationale of blood pepsinogen (PG) testing in population based screening settings.Methods: Participants from a cross-sectional population-based study of cardiovascular risk factors in Latvia were invited to participate in the current study. Pepsinogen I and II were measured in blood samples taken during the initial study and at follow-up; upper gastrointestinal endoscopy was performed. There were three groups of patients: with moderately decreased (PG I 〈 70 ng/ml and PG I/PG II ratio 〈 3), with strongly decreased (PG I 〈 30 ng/ml and PG I/PG II ratio 〈 2), and with normal PG level. Biopsy with H. pylori detection was performed (updated Sydney system).Results: Results from 259 patients were analyzed. Pepsinogens were decreased in 133 (51.4%), H. pylori was positive in 177 (66.0%) cases. Mean age was significantly lower in patients with normal compared to strongly decreased PG level group (52.8 vs. 64.1 years, p 〈 0.001). Prevalence of severe corpus atrophy was higher in the strongly decreased compared to the normal PG test group: 7.0% vs. 0%; the same tendency was noted in the distribution of OLGA stages III-IV – 10.5% and 0.0%, OLGIM stages III-IV – 3.5% and 0%, and low-grade dysplasia – 15.8% and 2.4% (p 〈 0.05). Two cases of gastric cancer were found; both presented decreased PG levels. A strong association between H. pylori eradication and PG ratio dynamics was found (p 〈 0.05).Conclusions: All high-risk lesions were found in the decreased PG test groups; two cancer cases were revealed.However, PG demonstrated low specificity and low value of repeated testing. The value of PG as a sole test for gastric cancer risk is limited.
    Type of Medium: Online Resource
    ISSN: 1842-1121 , 1841-8724
    URL: Article
    DOI: 10.15403/jgld.2014.1121.271.pep
    Language: Unknown
    Publisher: Romanian Society of Gastroenterology and Hepatology
    Publication Date: 2018
    detail.hit.zdb_id: 2253255-9
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  • 3
    Online Resource
    Online Resource
    Case report: High-volumetric atypical hemihepatectomy in patient with colorectal cancer with extensive metastatic disease
    Open Access Text Pvt, Ltd. ; 2017
    In:  Liver and Pancreatic Sciences Vol. 2, No. 1 ( 2017)
    Details
    In: Liver and Pancreatic Sciences, Open Access Text Pvt, Ltd., Vol. 2, No. 1 ( 2017)
    Type of Medium: Online Resource
    ISSN: 2513-986X
    URL: Journal
    URL: Article
    DOI: 10.15761/LPS
    DOI: 10.15761/LPS.1000110
    Language: Unknown
    Publisher: Open Access Text Pvt, Ltd.
    Publication Date: 2017
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  • 4
    Online Resource
    Online Resource
    Clinicopathological characteristics of Epstein-Barr virus-positive gastric cancer in Latvia
    Ovid Technologies (Wolters Kluwer Health) ; 2019
    In:  European Journal of Gastroenterology & Hepatology Vol. 31, No. 11 ( 2019-11), p. 1328-1333
    Details
    In: European Journal of Gastroenterology & Hepatology, Ovid Technologies (Wolters Kluwer Health), Vol. 31, No. 11 ( 2019-11), p. 1328-1333
    Abstract: Epstein-Barr virus (EBV)-associated gastric cancer has been proposed to be a distinct gastric cancer molecular subtype. The prognostic significance of EBV infection in gastric cancer remains unclear and needs further investigation. Our study aimed to analyze EBV-positive and EBV-negative gastric cancer patients regarding their personal and tumor-related characteristics, and compare their overall survival. Methods Gastric cancer patients consecutively treated at the Riga East University Hospital during 2009–2016 were identified retrospectively. Tumor EBV status was determined by in-situ hybridization for EBV-encoded RNA (EBER). Information about clinicopathological characteristics was obtained from patient questionnaires, hospital records. Overall survival was ascertained through 30 July 2017. Cox proportional hazard regression models adjusted for personal and tumor-related covariates compared survival between EBV-positive and EBV-negative patients. Results There were a total of 302 gastric cancer patients (61% males) with mean and SD age 63.6 ± 11.5 years. EBER positivity was present in 8.6% of tumors. EBV-positive gastric cancer patients had better survival at 80 months [adjusted hazard ratio = 0.37, 95% confidence interval (CI) = 0.19–0.72] compared to EBV-negative patients. Worse survival was observed for patients with stage III (hazard ratio = 2.76, 95% CI = 1.67–4.56) and stage IV (hazard ratio = 10.02, 95% CI = 5.72–17.57) compared to stage I gastric cancer, and overlapping and unspecified subsite (hazard ratio = 1.85; 95% CI = 1.14; 3.00) compared to distal tumors. Conclusion Tumor EBV positivity is a favorable prognostic factor in gastric cancer.
    Type of Medium: Online Resource
    ISSN: 0954-691X
    URL: Article
    DOI: 10.1097/MEG.0000000000001521
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2019
    detail.hit.zdb_id: 2030291-5
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