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  • 1
    Online Resource
    Online Resource
    Hyaluronic acid stimulation of stem cells for cardiac repair: a cell-free strategy for myocardial infarct
    Springer Science and Business Media LLC ; 2024
    In:  Journal of Nanobiotechnology Vol. 22, No. 1 ( 2024-04-04)
    Details
    In: Journal of Nanobiotechnology, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2024-04-04)
    Abstract: Myocardial infarction (MI), a representative form of ischemic heart disease, remains a huge burden worldwide. This study aimed to explore whether extracellular vesicles (EVs) secreted from hyaluronic acid (HA)-primed induced mesenchymal stem cells (HA-iMSC-EVs) could enhance the cardiac repair after MI. Results HA-iMSC-EVs showed typical characteristics for EVs such as morphology, size, and marker proteins expression. Compared with iMSC-EVs, HA-iMSC-EVs showed enhanced tube formation and survival against oxidative stress in endothelial cells, while reduced reactive oxygen species (ROS) generation in cardiomyocytes. In THP-1 macrophages, both types of EVs markedly reduced the expression of pro-inflammatory signaling players, whereas HA-iMSC-EVs were more potent in augmenting anti-inflammatory markers. A significant decrease of inflammasome proteins was observed in HA-iMSC-EV-treated THP-1. Further, phospho-SMAD2 as well as fibrosis markers in TGF-β1-stimulated cardiomyocytes were reduced in HA-iMSC-EVs treatment. Proteomic data showed that HA-iMSC-EVs were enriched with multiple pathways including immunity, extracellular matrix organization, angiogenesis, and cell cycle. The localization of HA-iMSC-EVs in myocardium was confirmed after delivery by either intravenous or intramyocardial route, with the latter increased intensity. Echocardiography revealed that intramyocardial HA-iMSC-EVs injections improved cardiac function and reduced adverse cardiac remodeling and necrotic size in MI heart. Histologically, MI hearts receiving HA-iMSC-EVs had increased capillary density and viable myocardium, while showed reduced fibrosis. Conclusions Our results suggest that HA-iMSC-EVs improve cardiac function by augmenting vessel growth, while reducing ROS generation, inflammation, and fibrosis in MI heart. Graphical Abstract
    Type of Medium: Online Resource
    ISSN: 1477-3155
    URL: Article
    DOI: 10.1186/s12951-024-02410-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2100022-0
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  • 2
    Online Resource
    Online Resource
    Efficacy of health coaching and a web‐based program on physical activity, weight, and distress management among cancer survivors: A multi‐centered randomised controlled trial
    Wiley ; 2020
    In:  Psycho-Oncology Vol. 29, No. 7 ( 2020-07), p. 1105-1114
    Details
    In: Psycho-Oncology, Wiley, Vol. 29, No. 7 ( 2020-07), p. 1105-1114
    Abstract: To investigate the efficacy of health coaching and a web‐based program on survivor physical activity (PA), weight, and distress management among stomach, colon, lung and breast cancer patients. Methods This randomised, controlled, 1‐year trial conducted in five hospitals recruited cancer survivors within 2 months of completing primary cancer treatment who had not met ≥1 of these behavioural goals: (i) conducting moderate PA for at least 150 minutes/week or strenuous exercise for over 75 minutes per week or, in the case of lung cancer patients, low or moderate intensity exercise for over 12.5 MET per week, (ii) maintaining normal weight, and (iii) attaining a score  〉 72 in the Post Traumatic Growth Inventory (PTGI). Participants were randomly assigned to one of three groups: the control group, a web‐only group, or a health coaching + web group. The primary endpoint was based on a composite of PA, weight, and PTGI score at 12 months. Results Patients in the health coaching + web group (difference = 6.6%, P = .010) and the web‐only group (difference = 5.9%, P = .031) had greater overall improvements across the three‐outcome composite than the control group. The health coaching + web group had greater overall improvement in PTGI (difference = 12.6%; P   〈  .001) than the control group, but not in PA and weight. Conclusion The web‐based program, with or without health coaching, may improve health behaviours including PA, weight, and distress management among cancer survivors within 2 months of completing primary cancer treatment. The web‐based program with health coaching was mainly effective for reducing psychological distress.
    Type of Medium: Online Resource
    ISSN: 1057-9249 , 1099-1611
    URL: Issue
    URL: Article
    DOI: 10.1002/pon.v29.7
    DOI: 10.1002/pon.5394
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1495115-0
    SSG: 5,2
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  • 3
    Online Resource
    Online Resource
    A Double-Blind, Randomized, Placebo-Controlled, Phase II Clinical Study To Evaluate the Efficacy and Safety of Camostat Mesylate (DWJ1248) in Adult Patients with Mild to Moderate COVID-19
    American Society for Microbiology ; 2023
    In:  Antimicrobial Agents and Chemotherapy Vol. 67, No. 1 ( 2023-01-24)
    Details
    In: Antimicrobial Agents and Chemotherapy, American Society for Microbiology, Vol. 67, No. 1 ( 2023-01-24)
    Abstract: Although several antiviral agents have become available for coronavirus disease 2019 (COVID-19) treatment, oral drugs are still limited. Camostat mesylate, an orally bioavailable serine protease inhibitor, has been used to treat chronic pancreatitis in South Korea, and it has an in vitro inhibitory potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study was a double-blind, randomized, placebo-controlled, multicenter, phase 2 clinical trial in mild to moderate COVID-19 patients. We randomly assigned patients to receive either camostat mesylate (DWJ1248) or placebo orally for 14 days. The primary endpoint was time to clinical improvement of subject symptoms within 14 days, measured using a subjective 4-point Likert scale. Three hundred forty-two patients were randomized. The primary endpoint was nonsignificant, where the median times to clinical improvement were 7 and 8 days in the camostat mesylate group and the placebo group, respectively (hazard ratio [HR] = 1.09; 95% confidence interval [CI] , 0.84 to 1.43; P  = 0.50). A post hoc analysis showed that the difference was greatest at day 7, without reaching significance. In the high-risk group, the proportions of patients with clinical improvement up to 7 days were 45.8% (50/109) in the camostat group and 38.4% (40/104) in the placebo group (odds ratio [OR] = 1.33; 95% CI, 0.77 to 2.31; P  = 0.31); the ordinal scale score at day 7 improved in 20.0% (18/90) of the camostat group and 13.3% (12/90) of the placebo group (OR = 1.68; 95% CI, 0.75 to 3.78; P  = 0.21). Adverse events were similar in the two groups. Camostat mesylate was safe in the treatment of COVID-19. Although this study did not show clinical benefit in patients with mild to moderate COVID-19, further clinical studies for high-risk patients are needed. (This trial was registered with ClinicalTrials.gov under registration no. NCT04521296).
    Type of Medium: Online Resource
    ISSN: 0066-4804 , 1098-6596
    URL: Article
    DOI: 10.1128/aac.00452-22
    RVK:
    XA 24552
    Language: English
    Publisher: American Society for Microbiology
    Publication Date: 2023
    detail.hit.zdb_id: 1496156-8
    SSG: 12
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Development and Validation of the Mood Instability Questionnaire-Trait (MIQ-T)
    MDPI AG ; 2021
    In:  Medicina Vol. 57, No. 8 ( 2021-08-18), p. 838-
    Details
    In: Medicina, MDPI AG, Vol. 57, No. 8 ( 2021-08-18), p. 838-
    Abstract: Background and objectives: Mood instability (MI) is a stable trait associated with psychiatric disorders, yet there is a lack of tools to measure MI. The purpose of this study was to develop and validate the Mood Instability Questionnaire-Trait (MIQ-T) to evaluate MI in mood disorder patients. Material and methods: Items were taken from various established questionnaires to create an initial list of MIQ-T questions. Data from 309 psychiatric patients (n = 309; 62 major depressive disorder, 58 bipolar I disorder, and 189 bipolar II disorder) were gathered from their medical records and were utilized in an exploratory factor analysis to clarify the underlying components of MI. Then, anonymous survey data from 288 individuals from the general population were included in the analysis as a comparison group. Associations between MIQ-T and other previously validated clinical instruments for mood disorders were examined to test external validity. Results: The exploratory factor analysis demonstrated that the five-factor structure (Lability, Upward Tendency, Downward Tendency, Childhood Instability, and Seasonality) of 59 items was the most appropriate with clear, cohesive features. MIQ-T exhibited high internal consistency (α = 0.96) and moderate to strong correlations with other previously validated clinical instruments, which were consistent with theoretical predictions, providing evidence of criterion validity. Short forms were also created to address the high internal consistency value, which can indicate redundancy, and to increase the approachability of the measure. We found that the patients with bipolar II disorder had higher MIQ-T scores than the patients with bipolar I disorder or major depressive disorder and the comparison group. Conclusion: Together, these findings validate the newly developed MIQ-T as an instrument of mood instability. MIQ-T can be a potential research tool for mood disorder.
    Type of Medium: Online Resource
    ISSN: 1648-9144
    URL: Article
    DOI: 10.3390/medicina57080838
    Language: English
    Publisher: MDPI AG
    Publication Date: 2021
    detail.hit.zdb_id: 2088820-X
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  • 5
    Online Resource
    Online Resource
    Neuronal specific βPix‐b stimulates actin‐dependent processes via the interaction between its PRD and WH1 domain of N‐WASP
    Wiley ; 2012
    In:  Journal of Cellular Physiology Vol. 227, No. 4 ( 2012-04), p. 1476-1484
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 227, No. 4 ( 2012-04), p. 1476-1484
    Abstract: βPix, a Pak‐interacting nucleotide exchange factor (Cool‐1/p85SPR), is a Cdc42/Rac1‐specific guanine nucleotide exchange factor (GEF) involved in various actin‐related processes. Many previous studies have focused on ubiquitously expressed βPix‐a, while the role of the neuronal‐specific isoform βPix‐b is still unknown, especially whether its role is distinct from or similar to βPix‐a. Here we show that unlike βPix‐a, overexpression of βPix‐b stimulates actin‐dependent comet formation in BHK21 cells. This effect is attributed to the interaction between its proline‐rich domain (PRD) and the WH1 domain of N‐WASP. In addition, we show that overexpression of βPix‐b stimulates actin‐dependent dendritic spine formation in rat hippocampal neurons in culture, a formation that is blocked by co‐expression of the WH1 domain of N‐WASP or the PRD of βPix‐b. Knocking‐down endogenous expression of βPix‐b by shRNA reduced the number of dendritic spines, which were rescued only by PRD‐containing βPix‐b mutants. GEF activity of βPix‐b is also required for these effects. The results show that neuronal‐specific βPix‐b stimulates actin‐dependent processes in cells via the interaction between its PRD and the WH1 domain of N‐WASP. Our results identify N‐WASP as the first protein shown to interact with the PRD of βPix‐b, raising the possibility that, as an N‐WASP WH1‐binding protein, βPix‐b may regulate N‐WASP's activity in cells. J. Cell. Physiol. 227: 1476–1484, 2012. © 2011 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v227.4
    DOI: 10.1002/jcp.22863
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 1478143-8
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Borderline Personality Pathology in Major Depressive Disorder, Bipolar I and II Disorder, and Its Relationship With Childhood Trauma
    Korean Neuropsychiatric Association ; 2022
    In:  Psychiatry Investigation Vol. 19, No. 11 ( 2022-11-25), p. 909-918
    Details
    In: Psychiatry Investigation, Korean Neuropsychiatric Association, Vol. 19, No. 11 ( 2022-11-25), p. 909-918
    Abstract: Objective Mood disorder and borderline personality pathology (BPP) are frequently comorbid and relate to childhood trauma. We investigated the relationship between childhood trauma and BPP features in mood disorder patients versus controls.Methods A total of 488 mood disorder patients, particularly major depressive disorder (MDD), bipolar I disorder (BD I), and bipolar II disorder (BD II), and 734 controls were included. We examined between-group BPP-related differences and correlated between BPP and childhood trauma using the Childhood Trauma Questionnaire-Short Form (CTQ) and the Personality Assessment Inventory–Borderline Features Scale.Results BD II patients showed significantly higher BPP. Emotional abuse and neglect were prominently associated with BPP, while affective instability and negative relationships exhibited a stronger association with childhood trauma. We also found a positive relationship between childhood trauma and BPP in MDD, BD I, and BD II patients.Conclusion The findings of the present study imply that BPP features are more likely to be found in patients with BD II than BD I or MDD. Mood disorder patients with severe childhood trauma may have higher BPP features. Thus, further study of the relationship between childhood trauma and BPP features could improve the therapeutic approaches and help understand patients with mood disorders.
    Type of Medium: Online Resource
    ISSN: 1738-3684 , 1976-3026
    URL: Article
    DOI: 10.30773/pi.2022.0114
    Language: English
    Publisher: Korean Neuropsychiatric Association
    Publication Date: 2022
    detail.hit.zdb_id: 2414488-5
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  • 7
    Online Resource
    Online Resource
    SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane
    The Company of Biologists ; 2010
    In:  Journal of Cell Science Vol. 123, No. 10 ( 2010-05-15), p. 1742-1750
    Details
    In: Journal of Cell Science, The Company of Biologists, Vol. 123, No. 10 ( 2010-05-15), p. 1742-1750
    Abstract: SNX18 and SNX9 are members of a subfamily of SNX (sorting nexin) proteins with the same domain structure. Although a recent report showed that SNX18 and SNX9 localize differently in cells and appear to function in different trafficking pathways, concrete evidence regarding whether they act together or separately in intracellular trafficking is still lacking. Here, we show that SNX18 has a similar role to SNX9 in endocytic trafficking at the plasma membrane, rather than having a distinct role. SNX18 and SNX9 are expressed together in most cell lines, but to a different extent. Like SNX9, SNX18 interacts with dynamin and stimulates the basal GTPase activity of dynamin. It also interacts with neuronal Wiskott-Aldrich syndrome protein (N-WASP) and synaptojanin, as does SNX9. SNX18 and SNX9 can form a heterodimer and colocalize in tubular membrane structures. Depletion of SNX18 by small hairpin RNA inhibited transferrin uptake. SNX18 successfully compensates for SNX9 deficiency during clathrin-mediated endocytosis and vice versa. Total internal reflection fluorescence microscopy in living cells shows that a transient burst of SNX18 recruitment to clathrin-coated pits coincides spatiotemporally with a burst of dynamin and SNX9. Taken together, our results suggest that SNX18 functions with SNX9 in multiple pathways of endocytosis at the plasma membrane and that they are functionally redundant.
    Type of Medium: Online Resource
    ISSN: 1477-9137 , 0021-9533
    URL: Article
    DOI: 10.1242/jcs.064170
    Language: English
    Publisher: The Company of Biologists
    Publication Date: 2010
    detail.hit.zdb_id: 219171-4
    detail.hit.zdb_id: 1483099-1
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Linkage of the locus for canine dewclaw to chromosome 16
    Elsevier BV ; 2004
    In:  Genomics Vol. 83, No. 2 ( 2004-2), p. 216-224
    Details
    In: Genomics, Elsevier BV, Vol. 83, No. 2 ( 2004-2), p. 216-224
    Type of Medium: Online Resource
    ISSN: 0888-7543
    URL: Article
    DOI: 10.1016/S0888-7543(03)00234-9
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2004
    detail.hit.zdb_id: 1468023-3
    SSG: 12
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  • 9
    Online Resource
    Online Resource
    A Retrospective Study of First-Line Therapy Involving Immune Checkpoint Inhibitors in Patients With Poor Risk Metastatic Renal Cell Carcinoma
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 12 ( 2022-4-28)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-4-28)
    Abstract: Patients with International Metastatic RCC Database Consortium (IMDC) poor risk metastatic renal cell carcinoma (mRCC) rarely respond to first-line tyrosine kinase inhibitors (TKIs) including sunitinib, and carries a very poor prognosis. In recent years, combination therapy involving immune checkpoint inhibitors (ICIs) have demonstrated superior efficacy to sunitinib in poor risk disease. Materials and Methods In a retrospective study using a cancer chemotherapy registry, 206 consecutive patients with mRCC in the first-line setting were identified between Oct 2019 and Dec 2020. Sixty-one patients had a poor risk mRCC, and were treated with TKI monotherapy (n=36), nivolumab plus ipilimumab (n=16), or pembrolizumab plus axitinib (n=9). Endpoints included overall survival (OS), progression-free survival (PFS), response rate (RR), and safety. Results Patients’ median age was 61 years and the median number of risk factors was 3 (range, 3-5). During a median 23.0 months of follow-up, the median OS was 24.3 months with ICI-based combinations and 14.8 months with TKI monotherapy, and the median PFS periods were 9.3 months and 3.4 months, respectively. An objective response occurred in 60% of the patients receiving ICI-based combinations and in 19% of those receiving TKI monotherapy (P=0.001). In the multivariate regression model, number of IMDC risk factors and the ICI-based combination therapy were independent prognostic factors for PFS. All-causality grade 3 or 4 adverse events were 44% for ICI-based combinations and 50% for TKI monotherapy. Conclusions Among patients with poor risk mRCC, first-line ICI-based therapy showed significantly longer OS and PFS, as well as a higher RR, than TKI monotherapy.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2022.874385
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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  • 10
    Online Resource
    Online Resource
    Current Prophylactic Hypothermia for Intracranial Hypertension after Traumatic Brain Injury
    Korean Neurointensive Care Society ; 2020
    In:  Journal of Neurointensive Care Vol. 3, No. 2 ( 2020-10-30), p. 29-32
    Details
    In: Journal of Neurointensive Care, Korean Neurointensive Care Society, Vol. 3, No. 2 ( 2020-10-30), p. 29-32
    Type of Medium: Online Resource
    ISSN: 2635-5280
    URL: Article
    DOI: 10.32587/jnic.2020.00311
    Language: English
    Publisher: Korean Neurointensive Care Society
    Publication Date: 2020
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