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  • 1
    Online Resource
    Online Resource
    Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2
    Springer Science and Business Media LLC ; 2023
    In:  Clinical Research in Cardiology Vol. 112, No. 10 ( 2023-10), p. 1372-1381
    Details
    In: Clinical Research in Cardiology, Springer Science and Business Media LLC, Vol. 112, No. 10 ( 2023-10), p. 1372-1381
    Abstract: Right ventricular (RV) function plays a critical role in the pathophysiology and acute prognosis of pulmonary embolism (PE). We analyzed the temporal changes of RV function in the cohort of a prospective multicentre study investigating if an early switch to oral anticoagulation in patients with intermediate-risk PE is effective and safe. Methods Echocardiographic and laboratory examinations were performed at baseline (PE diagnosis), 6 days and 6 months. Echocardiographic parameters were classified into categories representing RV size, RV free wall/tricuspid annulus motion, RV pressure overload and right atrial (RA)/central venous pressure. Results RV dysfunction based on any abnormal echocardiographic parameter was present in 84% of patients at baseline. RV dilatation was the most frequently abnormal finding (40.6%), followed by increased RA/central venous pressure (34.6%), RV pressure overload (32.1%), and reduced RV free wall/tricuspid annulus motion (20.9%). As early as day 6, RV size remained normal or improved in 260 patients (64.7%), RV free wall/tricuspid annulus motion in 301 (74.9%), RV pressure overload in 297 (73.9%), and RA/central venous pressure in 254 (63.2%). At day 180, the frequencies slightly increased. The median NT-proBNP level decreased from 1448 pg/ml at baseline to 256.5 on day 6 and 127 on day 180. Conclusion In the majority of patients with acute intermediate-risk PE switched early to a direct oral anticoagulant, echocardiographic parameters of RV function normalised within 6 days and remained normal throughout the first 6 months. Almost one in four patients, however, continued to have evidence of RV dysfunction over the long term. Graphical Abstract
    Type of Medium: Online Resource
    ISSN: 1861-0684 , 1861-0692
    URL: Article
    DOI: 10.1007/s00392-022-02138-4
    RVK:
    XA 37040
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2218331-0
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  • 2
    Online Resource
    Online Resource
    Diabetes mellitus, obesity and chronic pancreatitis? Independent risk factors for pancreatic adenocarcinoma (PAC) in Romanian Black Sea coast area
    Elsevier BV ; 2015
    In:  Pancreatology Vol. 15, No. 3 ( 2015-06), p. S86-
    Details
    In: Pancreatology, Elsevier BV, Vol. 15, No. 3 ( 2015-06), p. S86-
    Type of Medium: Online Resource
    ISSN: 1424-3903
    URL: Article
    DOI: 10.1016/j.pan.2015.05.316
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2015
    detail.hit.zdb_id: 2043694-4
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  • 3
    Online Resource
    Online Resource
    Upper endoscopy in patients with acute ST-elevation myocardial infarction (STEMI) and postthrombolysis upper gastrointestinal bleeding – results, therapeutic utility
    Walter de Gruyter GmbH ; 2012
    In:  ARS Medica Tomitana Vol. 18, No. 3 ( 2012-08-1), p. 146-150
    Details
    In: ARS Medica Tomitana, Walter de Gruyter GmbH, Vol. 18, No. 3 ( 2012-08-1), p. 146-150
    Abstract: Upper endoscopy is the “golden standard” for the diagnosis of upper gastrointestinal bleeding (UGB); it appreciates the persistence of bleeding in more than 90% of cases, it reveals the UGB lesion, gives prognostic information about re-bleeding risk and offers the possibility of endoscopic haemostasis. Uncomplicated STEMI by itself is not a contraindication for upper endoscopy [1,2]. The aim of our study was to observe the haemorrhagic lesions in STEMI patients with postthrombolysis UGB and to evaluate the safety and therapeutic utility of upper endoscopy in this category of patients. We performed upper endoscopy in STEMI patients with postthrombolytic UGB during a period of 4 years (1st of Jan 2008 - 31st of Dec 2011). Patients with systolic blood pressure (SBP) 〈 100 mmHg, with Killip class 〉 1, with unstable ECG and/or with severe associated conditions (respiratory distress, cerebrovascular stroke, consciousness disorders) were withdrawn from undergoing upper endoscopy, as well as patients who refused the investigation. During studied period, 618 STEMI patients underwent pharmacological coronary reperfusion. Postthrombolysis UGB occurred in 42 of them (6.79%). We could perform upper endoscopy in 30 patients (71.43%), the rest of 12 (28.57%) being withdrawn from endoscopy (6 patients with Killip class 〉 1, 4 patients with systolic blood pressure 〈 100mmHg, 2 patients refused the investigation). Incriminated haemorrhagic lesions were: erosive gastroduodenitis in 20 cases (66.67%) and duodenal ulcer in 10 cases (33.33%). As about therapeutic utility, amongst 30 patients investigated just 4 needed endoscopic treatment (haemoclips used in Forrest IB patients with duodenal ulcers). Endoscopy was a safe investigation in STEMI patients with postthrombolysis UGB. Erosive gastroduodenitis was incriminated as the source of bleeding in most of the cases. As it concerns the therapeutic utility of UE in STEMI patients with UGB, 13.33% of bleeding patients benefited from endoscopic treatment (mechanical haemmostasis).
    Type of Medium: Online Resource
    ISSN: 1841-4036
    URL: Article
    DOI: 10.2478/v10307-012-0022-x
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2012
    detail.hit.zdb_id: 2860314-X
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  • 4
    Online Resource
    Online Resource
    Specific Adverse Effects of Bevacizumab in the Treatment of Non-Squamous Non-Small Cell Lung Cancer (NSCLC) in Clinical Practice
    Revista de Chimie SRL ; 2019
    In:  Revista de Chimie Vol. 69, No. 12 ( 2019-1-15), p. 3644-3647
    Details
    In: Revista de Chimie, Revista de Chimie SRL, Vol. 69, No. 12 ( 2019-1-15), p. 3644-3647
    Abstract: Lung cancer is the most common cause of cancer-related mortality, and non-small cell lung cancer (NSCLC) represents about 85% of all lung cancers. In the last years, novel targeted therapies have been developed and approved in the treatment of NSCLC. Angiogenesis is a very complex process, and cancer angiogenesis is the most important event concerning cancer growth, invasion and metastasis. VEGF signalling pathway plays a significant role in cancer angiogenesis, and it is demonstrated that VEGF levels are correlated with increased angiogenesis and with poor prognosis and metastasis in NSCLC patients. Bevacizumab is a recombinant humanised monoclonal IgG1 antibody, it is one of the first agent used for anti-angiogenic treatment, and it was approved for the treatment of non-squamous NSCLC in combination with chemotherapy.
    Type of Medium: Online Resource
    ISSN: 0034-7752 , 2668-8212
    URL: Article
    DOI: 10.37358/RC.18.12.6810
    Language: English
    Publisher: Revista de Chimie SRL
    Publication Date: 2019
    detail.hit.zdb_id: 2488208-2
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  • 5
    Online Resource
    Online Resource
    Involvement of Adiponectin in Early Phase of Acute Myocardial Infarction with ST-Segment Elevation (STEMI)
    Revista de Chimie SRL ; 2019
    In:  Revista de Chimie Vol. 70, No. 2 ( 2019-3-15), p. 522-526
    Details
    In: Revista de Chimie, Revista de Chimie SRL, Vol. 70, No. 2 ( 2019-3-15), p. 522-526
    Abstract: Adiponectin is secreted by fatty tissue; it has a peptide biochemical structure and among other roles, it seems to inhibit endothelial inflammation. C-reactive protein has an essential role in host defense. Troponin is a protein that is part of cardiac and skeletal muscle contraction. Myocardial infarction is an acute event defined as myocardial cell necrosis, caused by sudden and sustained ischemia. The purpose of our search work was to analyze the connection between various biomarkers over the early phase of acute STEMI: adiponectin, high sensitive-C reactive protein (hs-CRP), high sensitive-Troponin T (hs-Troponin T), triglycerides, total -, LDL- and HDL-cholesterol. Our study included two groups of patients - one group of 30 patients diagnosed with STEMI in the first 12 h after onset, and the second group of 30 patients with unstable angina pectoris, normal hs-Troponin T, and normal findings at coronary angiography computed tomography (CT). Subjects in the STEMI-arm had a higher serum level of hs-CRP, hs-Troponin T, total cholesterol, LDL cholesterol, triglycerides, and decreased levels of HDL-cholesterol and adiponectin than those in the angina-arm. We identified diminished adiponectin plasma concentrations during the first hours of STEMI evolution. We also found out a directly proportional ratio among adiponectin and HDL-cholesterol and an inverse report between this hormone and all other studied biomarkers. Our results may support the anti-inflammatory and anti-atherogenic features of adiponectin.
    Type of Medium: Online Resource
    ISSN: 0034-7752 , 2668-8212
    URL: Article
    DOI: 10.37358/RC.19.2.6948
    Language: English
    Publisher: Revista de Chimie SRL
    Publication Date: 2019
    detail.hit.zdb_id: 2488208-2
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  • 6
    Online Resource
    Online Resource
    A case of late diagnosis of Gaucher disease with lung involvement (case study)
    Walter de Gruyter GmbH ; 2015
    In:  ARS Medica Tomitana Vol. 21, No. 2 ( 2015-5-1), p. 63-66
    Details
    In: ARS Medica Tomitana, Walter de Gruyter GmbH, Vol. 21, No. 2 ( 2015-5-1), p. 63-66
    Abstract: The present authors report the case of an adult male with no medical history, who developed prolonged fever of unknown cause, progression of anemia and lung fibrosis. A hematological disease was suspected and further investigations were done. The bone marrow aspirate raised the suspicion of Gaucher’s disease. The positive diagnosis was Gaucher’s disease with lung involvement (pulmonary fibrosis and pulmonary hypertension), and cardiac involvement (restrictive cardiomyopathy). Clinical evolution was unfavorable, and the patient died of cardiorespiratory failure. In conclusion, the present case report illustrates a late diagnosis of Gaucher’s disease with lung and cardiac involvement resulting in death in a short period
    Type of Medium: Online Resource
    ISSN: 1841-4036
    URL: Article
    DOI: 10.1515/arsm-2015-0022
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2015
    detail.hit.zdb_id: 2860314-X
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  • 7
    Online Resource
    Online Resource
    “Bare Metal” Stent Placement Complications: Interventional Treatment
    Walter de Gruyter GmbH ; 2016
    In:  ARS Medica Tomitana Vol. 22, No. 4 ( 2016-11-1), p. 285-289
    Details
    In: ARS Medica Tomitana, Walter de Gruyter GmbH, Vol. 22, No. 4 ( 2016-11-1), p. 285-289
    Abstract: The rapid implementation of stents in standard practice and expansion of the indication for their utilization also introduced a new problem: in-stent restenosis. Management of patients with restenosis after stent implantation is still considered an important clinical problem. Although balloon angioplasty is still one of the prefered strategies that provide satisfactory results and a low incidence of complication, repeat stenting with “drug eluting” stents or “drug balloon” angioplasty become a very atractive methods of treatment for selected lesions and patients.
    Type of Medium: Online Resource
    ISSN: 1841-4036
    URL: Article
    DOI: 10.1515/arsm-2016-0048
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2016
    detail.hit.zdb_id: 2860314-X
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  • 8
    Online Resource
    Online Resource
    Multifactorial Analysis of Cardiovascular Risk Factors in a Group of Patients with Acute Myocardial Infarction
    Walter de Gruyter GmbH ; 2014
    In:  Romanian Journal of Diabetes Nutrition and Metabolic Diseases Vol. 21, No. 4 ( 2014-12-1), p. 327-333
    Details
    In: Romanian Journal of Diabetes Nutrition and Metabolic Diseases, Walter de Gruyter GmbH, Vol. 21, No. 4 ( 2014-12-1), p. 327-333
    Abstract: Background and Aims: Acute myocardial infarction is one of the main causes of mortality worldwide, atherosclerosis being the most common mechanism of coronary artery obstruction. Many cardiovascular (CV) risk factors are associated with these pathogenic processes. The aim of our study was to investigate a group of patients with ST-segment elevation acute myocardial infarction in terms of the prevalence of cardiovascular risk factors. Materials and Methods: We investigated 97 patients with acute myocardial infarction (AMI) and 30 persons without AMI (control group) for CV risk parameters (metabolic syndrome, diabetes, sedentary, dyslipidemia, glycosylated hemoglobin- HbA1c), and the risk of developing AMI. Results: We found statistically significant differences (p 〈 0.05) for the patients with metabolic syndrome, diabetes, sedentary lifestyle, high level of total cholesterol, LDLc, HbA1c, low level of HDLc for the risk to develop AMI. Conclusion: This study emphasizes the need to implement measures of primary and secondary prevention, and carry out a strict control of cardiovascular risk factors as well as implicitly improve the therapeutic conduct.
    Type of Medium: Online Resource
    ISSN: 2284-6417
    URL: Article
    DOI: 10.2478/rjdnmd-2014-0040
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2014
    detail.hit.zdb_id: 2860636-X
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  • 9
    Online Resource
    Online Resource
    Diabetes Mellitus, Obesity and Underlying Non Alcoholic Fatty Liver Disease - Independent Risk Factors for Hepatocellular Carcinoma
    Walter de Gruyter GmbH ; 2013
    In:  Romanian Journal of Diabetes Nutrition and Metabolic Diseases Vol. 20, No. 2 ( 2013-06-1), p. 117-122
    Details
    In: Romanian Journal of Diabetes Nutrition and Metabolic Diseases, Walter de Gruyter GmbH, Vol. 20, No. 2 ( 2013-06-1), p. 117-122
    Abstract: Background and Aims . Hepatocellular carcinoma (HCC) is one of the most common malignancies. Obesity, together with the underlying liver steatosis, has received increased attention as a risk factor for HCC. Diabetes Mellitus (DM) is also reported to be associated with HCC. We aimed to estimate the risk of HCC in obese and diabetic patients. Material and method . We prospectively analyzed 414 obese and diabetic patients, over a period of 5 years. We evaluated all patients using screening methods such as abdominal ultrasound and serum alpha-fetoprotein every 6 month, in order to detect HCC occurrence. Kaplan-Meier analysis estimated the cumulative incidence of HCC. Univariate and multivariate Cox regression analysis assessed the association between HCC and obesity. Results . Median follow-up was 4.3 years. 11 from 77 cirrhotic obese patients, and 18 from 150 non-cirrhotic obese patients developed HCC (p=ns). 7 from 51 patients with DM and cirrhosis, and 14 from 136 non-cirrhotic patients with DM developed HCC (p=ns). The cumulative incidence of HCC was 2.8%, respectively 2.6%, in cirrhotic patients with obesity or DM, compared with 2.2%, respectively 2.0%, in non-cirrhotic patients with obesity or DM (p=ns). Conclusion . Obesity and DM, along with nonalcoholic fatty liver disease (NAFLD), seems to be independent risk factors for HCC occurrence.
    Type of Medium: Online Resource
    ISSN: 2284-6417 , 2068-8245
    URL: Article
    DOI: 10.2478/rjdnmd-2013-0014
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2013
    detail.hit.zdb_id: 2860636-X
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  • 10
    Online Resource
    Online Resource
    Capsule endoscopy – accurate diagnosis method for detection of obscure digestive bleedings and secondary chronic anemia
    Walter de Gruyter GmbH ; 2012
    In:  ARS Medica Tomitana Vol. 18, No. 2 ( 2012-12-1), p. 93-97
    Details
    In: ARS Medica Tomitana, Walter de Gruyter GmbH, Vol. 18, No. 2 ( 2012-12-1), p. 93-97
    Abstract: Background. Capsule endoscopy is a revolutionary new diagnostic method for the detection of digestive diseases, especially localized at the level of small bowel and colorectal tract. This method is the only technique that allows endoscopic examination of the digestive tract without sedation. Obscure gastrointestinal bleeding is the most common indication for capsule endoscopy, which commonly diagnoses arteriovenous malformations, small bowel tumors, ulcers or tumors missed at standard endoscopy or other imaging examinations [1]. Aim. Our study aimed to detect the accuracy of endoscopic videocapsule in detecting the cause of microscopic anemia in patients with supposed digestive pathologies. Material and method. We used PillCam 2 Platform provided by Given Imaging, a system consisting of PillCam 2 videocapsules, a data recorder, a set of sensors and the Rapid 7 Access computer soft capable to receive and transform pictures into films, in order to visualize the entire digestive gastrointestinal tract. We examined 25 patients with chronic anemia, all of them without any known hematologic, renal or digestive disease, investigated by standard imagistic and lab techniques. Results. From the total of 25 investigated patients, 18 (72%) of them presented sources of bleeding discovered with videocapsule endoscopy. The source of bleeding was the small bowel in 10 cases (55%) and the colorectal tract in 8 cases (45%). The accuracy of videocapsule was very good for detecting the digestive tract obscure sources of bleeding (Sn=74%, Sp=87%). Conclusions. The videocapsule endoscopy is an accurate imagistic option to detect digestive sources of bleeding and to identify the cause of many chronic anemia
    Type of Medium: Online Resource
    ISSN: 1841-4036
    URL: Article
    DOI: 10.2478/v10307-012-0019-5
    Language: English
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2012
    detail.hit.zdb_id: 2860314-X
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