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  • 1
    Online Resource
    Online Resource
    Case report of a long term cotton string granuloma mimicking intracranial tumour
    Romanian Society of Legal Medicine ; 2017
    In:  Romanian Journal of Legal Medicine Vol. 25, No. 1 ( 2017-03-20), p. 41-43
    Details
    In: Romanian Journal of Legal Medicine, Romanian Society of Legal Medicine, Vol. 25, No. 1 ( 2017-03-20), p. 41-43
    Type of Medium: Online Resource
    ISSN: 1221-8618 , 1844-8585
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.4323/rjlm.2017
    DOI: 10.4323/rjlm
    DOI: 10.4323/rjlm.2017.41
    Language: Unknown
    Publisher: Romanian Society of Legal Medicine
    Publication Date: 2017
    detail.hit.zdb_id: 2652619-0
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  • 2
    Online Resource
    Online Resource
    Parasagittal meningiomas – literature review and a case report
    Digital ProScholar Media ; 2017
    In:  Journal of Clinical and Investigative Surgery Vol. 2, No. 1 ( 2017-05-01), p. 39-44
    Details
    In: Journal of Clinical and Investigative Surgery, Digital ProScholar Media, Vol. 2, No. 1 ( 2017-05-01), p. 39-44
    Abstract: Meningiomas are tumors that can develop anywhere along the neuraxis, but with increased concentration in some specific areas. Parasagittal meningiomas have the dural attachment on the external layer of the superior sagittal sinus (SSS) and invade the parasagittal angle displacing brain away from its normal position. Among meningiomas, the parasagittal location is the most common (22%). Taking into account their anatomic insertion along SSS, parasagittal meningiomas can have their dural attachment in the anterior, the middle or the posterior third of the SSS. Most frequently parasagittal meningiomas are located in the middle third of the superior sagittal sinus (between coronal suture and lambdoid suture). The clinical picture of parasagittal meningiomas depends on the tumor location along the SSS and so is the attitude towards ligation and reconstruction of the sinus. Controversial issues regarding surgical management of parasagittal meningiomas concerning leaving a tumor remnant that invades the SSS instead attempting total resection, or the attitude in the case of totally occluded segment of a sinus are summarized in this paper. The special care for the venous system is emphasized. The recurrence matter is also approached underlining the importance of adjuvant radiosurgery for the management of residual tumors. Results described in the main papers of the literature are reviewed. Conclusions are referring to the historical evolution regarding the surgical management of parasagittal meningiomas: aggressiveness of resection, sinus reconstruction, importance of adjuvant techniques: radiosurgery, endovascular surgery and to the importance of microsurgery and careful and meticulous planning of the approach in order to avoid interference with venous collaterals. A suggestive clinical case from the authors experience is presented.
    Type of Medium: Online Resource
    ISSN: 2559-5555
    URL: Journal
    URL: Article
    DOI: 10.25083/2559-5555
    DOI: 10.25083/2559.5555.21.3944
    Language: Unknown
    Publisher: Digital ProScholar Media
    Publication Date: 2017
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  • 3
    Online Resource
    Online Resource
    Factors influencing the recurrence rate of operated chronic subdural hematomas
    Romanian Society of Neurosurgery ; 2016
    In:  Romanian Neurosurgery Vol. 30, No. 2 ( 2016-06-1), p. 162-167
    Details
    In: Romanian Neurosurgery, Romanian Society of Neurosurgery, Vol. 30, No. 2 ( 2016-06-1), p. 162-167
    Abstract: In this study we are trying to establish a correlation between the surgical technique used for the treatment of chronic subdural hematomas and the risk of recurrence. Between 01.06.2008 and 31.05.2014, 123 patients with 138 chronic subdural hematomas (CSDH) were operated on and followed-up in our department. Among them, 16 hematomas (11,6%) recurred. Factors related to the patients (gender, age, location of the hematoma) are analyzed as possible predictors of recurrence. Several surgical techniques were used in the treatment of chronic subdural hematomas. Each of them is analyzed to find possibly connections with the recurrence risk of the size of the approach, the reposition of the bone flap, the suture of the dura and other aspects. There are obvious, statistically significant correlations between the risk of recurrence and some elements of the surgical technique employed.
    Type of Medium: Online Resource
    ISSN: 2344-4959 , 1220-8841
    URL: Article
    DOI: 10.1515/romneu-2016-0026
    Language: Unknown
    Publisher: Romanian Society of Neurosurgery
    Publication Date: 2016
    detail.hit.zdb_id: 2595416-7
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  • 4
    Online Resource
    Online Resource
    Comparative Study of the Dyes Induced Citotoxicity in Cultures of Cerebelar Granular Neurons
    Revista de Chimie SRL ; 2019
    In:  Revista de Chimie Vol. 70, No. 7 ( 2019-8-15), p. 2439-2441
    Details
    In: Revista de Chimie, Revista de Chimie SRL, Vol. 70, No. 7 ( 2019-8-15), p. 2439-2441
    Abstract: Determining neural viability in cell cultures is an essential element in both fundamental and clinical research, including testing the efficacy of certain neuroprotective drug compounds. Therefore, for a more rigorous evaluation of neuronal death associated with either experimental conditions or experimental models of neurological diseases, it is important that the research method and especially the staining method does not produce additional neural injuries and does not change the number destroyed cells. In the present study we tested how several types of dyes: Trypan Blue (TB), Calcein AM, Hoechst 33342, Propidium Iodide and WST-1/Formazan, affect neuronal viability in cell cultures before and after hypoxia and also, which dyes are associated with a higher percentage of cytotoxicity.
    Type of Medium: Online Resource
    ISSN: 0034-7752 , 2668-8212
    URL: Article
    DOI: 10.37358/RC.19.7.7357
    Language: English
    Publisher: Revista de Chimie SRL
    Publication Date: 2019
    detail.hit.zdb_id: 2488208-2
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  • 5
    Online Resource
    Online Resource
    Analyze of Saliva Cortisol as Biomarker in Healthy Distressed Subjects
    Revista de Chimie SRL ; 2019
    In:  Revista de Chimie Vol. 70, No. 7 ( 2019-8-15), p. 2601-2603
    Details
    In: Revista de Chimie, Revista de Chimie SRL, Vol. 70, No. 7 ( 2019-8-15), p. 2601-2603
    Abstract: Stress investigation especially in young healthy adults is a main mental health issue due to its individual and social consequences on long term. In order to characterize physiological, pathological and biochemical mechanisms of stress response, several biomarkers were proposed. Among these, the evaluation of the salivary biomarkers represents a fast and simple procedure, both in healthy subjects and patients. Saliva contains a wide range of parameters reflecting physiologic endocrine and immune responses, such as biologically active form of certain hormones (e.g. cortisol), growth factors, immune molecules. The present article is focused on cortisol evaluation as possible biomarker of stress and its analyze in the context of literature data.
    Type of Medium: Online Resource
    ISSN: 0034-7752 , 2668-8212
    URL: Article
    DOI: 10.37358/RC.19.7.7387
    Language: English
    Publisher: Revista de Chimie SRL
    Publication Date: 2019
    detail.hit.zdb_id: 2488208-2
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  • 6
    Online Resource
    Online Resource
    Cinnarizine - Potential Trigger of the Dopamine Supersensitivity Psychosis in Patients with Paranoid Schizophrenia Particular neurobiochemical model
    Revista de Chimie SRL ; 2019
    In:  Revista de Chimie Vol. 70, No. 8 ( 2019-9-15), p. 3003-3007
    Details
    In: Revista de Chimie, Revista de Chimie SRL, Vol. 70, No. 8 ( 2019-9-15), p. 3003-3007
    Abstract: Supersensitivity psychosis is a subdiagnosed clinical reality. This entity, however, is insufficiently elucidated from the point of view of the neurobiochemical mechanisms involved in the pathogenesis. The combination of an antipsychotic with a high D2 receptor blocking capacity and a neuroleptic-like substance such as cinnarizine trigger the dopaminergic hypersensitivity mechanisms. This stimulates the sensitivity for dopamine in the prefrontal cortex, ameliorating the negative and cognitive symptoms at the thalamic level, remodeling sensory integration and decreasing tinnitus, as well as in the cerebral tonsil, consequently decreasing the risk of antisocial behavior.
    Type of Medium: Online Resource
    ISSN: 0034-7752 , 2668-8212
    URL: Article
    DOI: 10.37358/RC.19.8.7474
    Language: English
    Publisher: Revista de Chimie SRL
    Publication Date: 2019
    detail.hit.zdb_id: 2488208-2
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  • 7
    Online Resource
    Online Resource
    Stomach ‘tastes’ the food and adjusts its emptying: A neurophysiological hypothesis (Review)
    Spandidos Publications ; 2020
    In:  Experimental and Therapeutic Medicine ( 2020-06-11)
    Details
    In: Experimental and Therapeutic Medicine, Spandidos Publications, ( 2020-06-11)
    Type of Medium: Online Resource
    ISSN: 1792-0981 , 1792-1015
    URL: Journal
    URL: Article
    DOI: 10.3892/etm
    DOI: 10.3892/etm.2020.8874
    Language: Unknown
    Publisher: Spandidos Publications
    Publication Date: 2020
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  • 8
    Online Resource
    Online Resource
    The Predictive Role of Biochemical Plasma Factors in Patients with Severe Traumatic Brain Injuries
    Revista de Chimie SRL ; 2019
    In:  Revista de Chimie Vol. 70, No. 5 ( 2019-6-15), p. 1754-1757
    Details
    In: Revista de Chimie, Revista de Chimie SRL, Vol. 70, No. 5 ( 2019-6-15), p. 1754-1757
    Abstract: Traumatic brain injuries (TBI) represent a high impact public health problem due to a high rate of death , long term disability and occurrence especially in young adults. Despite several promising animal studies, several parameters were proposed as biological markers and were assessed for this aim. Our study proposes the study of the early biochemical changes in association to hematological parameters for severe TBI patients prognosis. 43 patients with acute TBI were included in study based on clinical, laboratory and imagistic findings. The severity of the TBI was established by Glasgow Coma Scale GCS 3-8. In all patients were evaluated hematologic parameters (Red blood cell count - RBC, Hematocrit, blood Hemoglobin, White blood cell - WBC, Platelet count and biochemical parameters (glucose, urea, creatinine, electrolytes). Outcome was expressed as Glasgow Outcome Scale (GOS), between 1-5. Values were compared to control group -15 cases. Significant early differences in body temperature, heart rate, and systolic blood pressure were observed in TBI group versus control (p[0.05). After correlation, laboratory findings significantly associated to severe outcome - GOS = 1, 2 - (p[0.05) were plasma Na decrease and significant glucose increase. An early increase of temperature and decrease of Na may predict a severe outcome in patients with acute TBI; association with shifts in heart rate and blood pressure, imposes aggressive treatment measures.
    Type of Medium: Online Resource
    ISSN: 0034-7752 , 2668-8212
    URL: Article
    DOI: 10.37358/RC.19.5.7209
    Language: English
    Publisher: Revista de Chimie SRL
    Publication Date: 2019
    detail.hit.zdb_id: 2488208-2
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  • 9
    Online Resource
    Online Resource
    Atypical olfactory groove meningioma associated with uterine fibromatosis; case report
    Digital ProScholar Media ; 2016
    In:  Journal of Clinical and Investigative Surgery Vol. 1, No. 2 ( 2016-11-01), p. 84-88
    Details
    In: Journal of Clinical and Investigative Surgery, Digital ProScholar Media, Vol. 1, No. 2 ( 2016-11-01), p. 84-88
    Abstract: The concomitant presence of the olfactory groove meningioma with uterine fibrosis is very rare. Our report presents the case of a giant olfactory groove meningioma revealed after a uterine fibroma resection in a 44 years-old female, due to a generalized seizure 10 days after operation. Cranial CT-scan identified the tumor as an olfactory groove meningioma. The tumor was operated with a macroscopically complete resection; the endothermal coagulation of the dura attachment was performed (Simpson II) with a good postoperative evolution. Laboratory results showed the presence of receptors for steroid hormones both in meningioma and uterine tumor, and the histopathological examination revealed an atypical meningioma with 17% proliferation markers. Our findings suggest that even though meningiomas are benign tumors and a complete resection usually indicates a good prognosis, the association with uterine fibromatosis and the presence of high percentage of steroid receptors creates a higher risk to relapse, imposing therefore a good monitoring.
    Type of Medium: Online Resource
    ISSN: 2559-5555
    URL: Journal
    URL: Article
    DOI: 10.25083/2559-5555
    DOI: 10.25083/2559.5555.12.8488
    Language: Unknown
    Publisher: Digital ProScholar Media
    Publication Date: 2016
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  • 10
    Online Resource
    Online Resource
    A rare case of multiple meningiomas with different histology
    Digital ProScholar Media ; 2017
    In:  Journal of Clinical and Investigative Surgery Vol. 2, No. 2 ( 2017-09-01), p. 114-119
    Details
    In: Journal of Clinical and Investigative Surgery, Digital ProScholar Media, Vol. 2, No. 2 ( 2017-09-01), p. 114-119
    Abstract: Meningiomas are generally benign tumors but sometimes they manifest tendency to progress towards malignancy. It is not yet clear if anaplastic meningiomas have an innate malignancy characteristic, or an initially beginning histological appearance that degenerates malignantly in time. According to literature data, the risk of a benign meningioma to progress towards malignant phenotype is about 0.16-2%, such malignant transformation occurring after a variable period of time (2-16 years). A still unanswered question is how many of the malignant meningiomas present this appearance as an innate feature and how many of them originate from benign meningiomas. Multiple meningiomas are defined as the presence of two or more distinct meningiomas. They occur in 6-10% of all patients that present meningiomas. Multiple meningiomas with a distinct histological appearance are rarely discovered. They support the theory of meningiomas that develop independently in the same patient. Different histology of multiple meningiomas is found in less than a third of the patients who suffer from this pathology. We are presenting the case of a patient with multiple meningiomas with distinct histology, one being benign and the other malignant. In connection with this case we are raising a question of therapeutic management in patients diagnosed with malignant meningiomas, namely if other possible small/ benign meningiomas should be also entirely resected.
    Type of Medium: Online Resource
    ISSN: 2559-5555
    URL: Journal
    URL: Article
    DOI: 10.25083/2559-5555
    DOI: 10.25083/2559.5555.22.114119
    Language: Unknown
    Publisher: Digital ProScholar Media
    Publication Date: 2017
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