In:
Chemical Communications, Royal Society of Chemistry (RSC), Vol. 58, No. 31 ( 2022), p. 4901-4904
Abstract:
Although extracellular regulated protein kinases (ERKs) are considered important targets for the treatment of various cancers, the occurrence of severe side effects in clinical trials restricts the development of ERK inhibitors. Here, we developed the first series of photocaged ERK inhibitors, which can be selectively activated by UV irradiation to release a highly potent ERK inhibitor in multiple cancer cell lines including A375, A549 and HCT116, and Compound 2 demonstrated clear anticancer activity in a zebrafish xenograft model. In conclusion, photocaged ERK inhibitor 2 provides a new strategy for precise cancer therapy.
Type of Medium:
Online Resource
ISSN:
1359-7345
,
1364-548X
Language:
English
Publisher:
Royal Society of Chemistry (RSC)
Publication Date:
2022
detail.hit.zdb_id:
1472881-3
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