GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Detection of a 4 bp Mutation in the 3′UTR Region of Goat Sox9 Gene and Its Effect on the Growth Traits
    MDPI AG ; 2020
    In:  Animals Vol. 10, No. 4 ( 2020-04-13), p. 672-
    Details
    In: Animals, MDPI AG, Vol. 10, No. 4 ( 2020-04-13), p. 672-
    Abstract: The SRY-type HMG box 9 (Sox9) gene plays an important role in chondrocyte development as well as changes in hypertrophic chondrocytes, indicating that Sox9 can regulate growth in animals. However, no studies to date have examined the correlation between variations in Sox9 and growth traits in goats. Here, we found a 4 bp indel in the 3′UTR of Sox9 and verified its association with growth traits in Shaanbei white cashmere goats (n = 1109). The frequencies of two genotypes (ID and II) were 0.397 and 0.603, respectively, and polymorphic information content (PIC) values showed that the indel had a medium PIC (PIC 〉 0.25). The 4 bp indel was significantly correlated with body length (p = 0.006), heart girth (p = 0.001), and hip width (p = 4.37 × 10 −4). Notably, individuals with the ID genotype had significantly superior phenotypic traits compared with individuals bearing the II genotype. Hence, we speculated that the 4 bp indel is an important mutation affecting growth traits in goat, and may serve as an effective DNA molecular marker for marker-assisted selection in goat breeding programs.
    Type of Medium: Online Resource
    ISSN: 2076-2615
    URL: Article
    DOI: 10.3390/ani10040672
    Language: English
    Publisher: MDPI AG
    Publication Date: 2020
    detail.hit.zdb_id: 2606558-7
    SSG: 23
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Frequency, determinants, and effects of early seizures after thrombolysis for acute ischemic stroke : The ENCHANTED trial
    Ovid Technologies (Wolters Kluwer Health) ; 2017
    In:  Neurology Clinical Practice Vol. 7, No. 4 ( 2017-08), p. 324-332
    Details
    In: Neurology Clinical Practice, Ovid Technologies (Wolters Kluwer Health), Vol. 7, No. 4 ( 2017-08), p. 324-332
    Type of Medium: Online Resource
    ISSN: 2163-0402 , 2163-0933
    URL: Article
    DOI: 10.1212/CPJ.0000000000000384
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
    detail.hit.zdb_id: 2645818-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Deletion of Mettl3 in mesenchymal stem cells promotes acute myeloid leukemia resistance to chemotherapy
    Springer Science and Business Media LLC ; 2023
    In:  Cell Death & Disease Vol. 14, No. 12 ( 2023-12-05)
    Details
    In: Cell Death & Disease, Springer Science and Business Media LLC, Vol. 14, No. 12 ( 2023-12-05)
    Abstract: Acute myeloid leukemia (AML) cell survival and chemoresistance are influenced by the existence of bone marrow mesenchymal stem cells (BMMSCs); however, the pathways by which BMMSCs contribute to these processes remain unclear. We earlier revealed that methyltransferase-like 3 (METTL3) expression is significantly reduced in AML BMMSCs and that METTL3 mediates BMMSC adipogenesis to promote chemoresistance in human AML cell lines in vitro. In this investigation, we evaluated the METTL3 function in vivo. Mice exhibiting a conditional removal of Mettl3 in BMMSCs were developed by mating Prrx1-Cre ERT2 ;Mettl3 fl/+ mice with Mettl3 fl/fl mice using the CRISPR-Cas9 system. The Mettl3 deletion increased bone marrow adiposity, enhanced disease progression in the transplantation-induced MLL-AF9 AML mouse model, and chemoresistance to cytarabine. The removal of Mettl3 in BMMSCs resulted in a significant increase in BMMSC adipogenesis. This effect was attributed to the downregulation of AKT1 expression, an AKT serine/threonine kinase 1, in an m 6 A-dependent manner. The development of chemoresistance in AML is linked to the promoted adipogenesis of BMMSCs. We conclude that METTL3 expression in BMMSCs has a critical function in limiting AML progression and chemoresistance, providing a basis for the progression of therapeutic approaches for AML.
    Type of Medium: Online Resource
    ISSN: 2041-4889
    URL: Article
    DOI: 10.1038/s41419-023-06325-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2541626-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Nutrient Removal from Chinese Coastal Waters by Large-Scale Seaweed Aquaculture Using Artificial Upwelling
    MDPI AG ; 2019
    In:  Water Vol. 11, No. 9 ( 2019-08-22), p. 1754-
    Details
    In: Water, MDPI AG, Vol. 11, No. 9 ( 2019-08-22), p. 1754-
    Abstract: Ecological engineering by artificial upwelling for enhancing seaweed growth and consequently increasing nutrient removal from seawater has proved promising in combating intense coastal eutrophication. However, a key issue needs to be answered: how much economic and ecological benefit could this engineering bring if it were to be implemented in national aquaculture areas. This study estimated the promoting effect of nutrient concentration change induced by artificial upwelling on kelp growth using a model simulation based on the temperature, light intensity, and nutrient concentration data from three bays in Shandong Province, China— Aoshan Bay, Jiaozhou Bay, and Sanggou Bay. Our results indicate that ecological engineering by artificial upwelling can increase the average yield of kelp by 55 g per plant. Furthermore, based on the current existing kelp aquaculture area of China and the aquaculture density of 12 plants/m2, we inferred that this ecological engineering could increase the natural kelp yield by 291,956 t and the removal of nitrogen (N) and phosphorus (P) nutrients by 4875–6422 t and 730–1080 t, respectively.
    Type of Medium: Online Resource
    ISSN: 2073-4441
    URL: Article
    DOI: 10.3390/w11091754
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2521238-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Transcriptome study of oleanolic acid in the inhibition of breast tumor growth based on high-throughput sequencing
    Impact Journals, LLC ; 2021
    In:  Aging Vol. 13, No. 19 ( 2021-10-15), p. 22883-22897
    Details
    In: Aging, Impact Journals, LLC, Vol. 13, No. 19 ( 2021-10-15), p. 22883-22897
    Type of Medium: Online Resource
    ISSN: 1945-4589
    URL: Issue
    URL: Article
    DOI: 10.18632/aging.v13i19
    DOI: 10.18632/aging.203582
    Language: English
    Publisher: Impact Journals, LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2535337-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Semi-dynamic spatial–temporal graph neural network for traffic state prediction in waterways
    Elsevier BV ; 2024
    In:  Ocean Engineering Vol. 293 ( 2024-02), p. 116685-
    Details
    In: Ocean Engineering, Elsevier BV, Vol. 293 ( 2024-02), p. 116685-
    Type of Medium: Online Resource
    ISSN: 0029-8018
    URL: Article
    DOI: 10.1016/j.oceaneng.2024.116685
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 160791-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Development and validation of nomogram for predicting early recurrence after radical gastrectomy of gastric cancer
    Springer Science and Business Media LLC ; 2024
    In:  World Journal of Surgical Oncology Vol. 22, No. 1 ( 2024-01-19)
    Details
    In: World Journal of Surgical Oncology, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2024-01-19)
    Abstract: After radical surgery, early detection of recurrence and metastasis is a crucial factor in enhancing the prognosis and survival of patients with gastric cancer (GC). Therefore, assessing the risk of recurrence in gastric cancer patients and determining the timing for postoperative recurrence is crucial. Methods The clinicopathological data of 521 patients with recurrent gastric cancer, who underwent radical gastrectomy at Zhejiang Cancer Hospital between January 2010 and January 2017, were retrospectively analyzed. These patients were randomly divided into two groups: a training group ( n  = 365) and a validation group ( n  = 156). In the training set, patients were further categorized into early recurrence ( n  = 263) and late recurrence ( n  = 102) groups based on a 2-year boundary. Comparative analyses of clinicopathological features and prognoses were conducted between these two groups. Subsequently, a nomogram for predicting early recurrence was developed and validated. Results In this study, the developed nomogram incorporated age, serous infiltration, lymph node metastasis, recurrence mode, and the tumour marker CA19-9. In the training cohort, the area under the curve (AUC value) was 0.739 (95% CI, 0.682–0.798), with a corresponding C-index of 0.739. This nomogram was subsequently validated in an independent validation cohort, yielding an AUC of 0.743 (95% CI, 0.652–0.833) and a C-index of 0.743. Furthermore, independent risk factors for prognosis were identified, including age, absence of postoperative chemotherapy, early recurrence, lymph node metastasis, abdominal metastasis, and vascular cancer embolus. Conclusion Independent risk factors for gastric cancer recurrence following radical surgery were utilized to construct a nomogram for predicting early relapse. This nomogram effectively assesses the risk of recurrence, aids in treatment decision-making and follow-up planning in clinical settings, and demonstrated strong performance in the validation cohort.
    Type of Medium: Online Resource
    ISSN: 1477-7819
    URL: Article
    DOI: 10.1186/s12957-023-03294-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2024
    detail.hit.zdb_id: 2118383-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Voluntary Exercise to Reduce Anxiety Behaviour in Traumatic Brain Injury Shown to Alleviate Inflammatory Brain Response in Mice
    MDPI AG ; 2023
    In:  International Journal of Molecular Sciences Vol. 24, No. 7 ( 2023-03-28), p. 6365-
    Details
    In: International Journal of Molecular Sciences, MDPI AG, Vol. 24, No. 7 ( 2023-03-28), p. 6365-
    Abstract: Traumatic brain injury is a leading cause of neuroinflammation and anxiety disorders in young adults. Immune-targeted therapies have garnered attention for the amelioration of TBI-induced anxiety. A previous study has indicated that voluntary exercise intervention following TBI could reduce neuroinflammation. It is essential to determine the effects of voluntary exercise after TBI on anxiety via inhibiting neuroinflammatory response. Mice were randomly divided into four groups (sham, TBI, sham + voluntary wheel running (VWR), and TBI + VWR). One-week VWR was carried out on the 2nd day after trauma. The neurofunction of TBI mice was assessed. Following VWR, anxiety behavior was evaluated, and neuroinflammatory responses in the perilesional cortex were investigated. Results showed that after one week of VWR, neurofunctional recovery was enhanced, while the anxiety behavior of TBI mice was significantly alleviated. The level of pro-inflammatory factors decreased, and the level of anti-inflammatory factors elevated. Activation of nucleotide oligomerization domain-like thermal receptor protein domain associated protein 3 (NLRP3) inflammasome was inhibited significantly. All these alterations were consistent with reduced microglial activation at the perilesional site and positively correlated with the amelioration of anxiety behavior. This suggested that timely rehabilitative exercise could be a useful therapeutic strategy for anxiety resulting from TBI by targeting neuroinflammation.
    Type of Medium: Online Resource
    ISSN: 1422-0067
    URL: Article
    DOI: 10.3390/ijms24076365
    Language: English
    Publisher: MDPI AG
    Publication Date: 2023
    detail.hit.zdb_id: 2019364-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Clinical phase I/II trial of SVF therapy for cartilage regeneration: A cellular therapy with novel 3D MRI imaging for evaluating chondral defect of knee osteoarthritis
    Frontiers Media SA ; 2023
    In:  Frontiers in Cell and Developmental Biology Vol. 11 ( 2023-1-19)
    Details
    In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 11 ( 2023-1-19)
    Abstract: Background: The clinical applications of stromal vascular fraction (SVF) therapy for osteoarthritis (OA) have attracted academic and clinical attention. However, data of the effects of stromal vascular fraction therapy on regeneration of degenerated cartilage are limited in the literature. Meanwhile, there is a great need for a simple and non-invasive evaluation method to analyze the changes of joint cartilage qualitatively and quantitatively in clinical trials. This study entitled “stromal vascular fraction Therapy for Human Knee Osteoarthritis” was registered in ClinicalTrial.gov # NCT05019378. Materials and Methods: We designed and conducted a single center, open labeled clinical phase I/II study, and 6 osteoarthritis patients with both knee cartilage defect I-II were enrolled in this study. The two knees of each patient were randomly assigned to autologous stromal vascular fraction treatment group or non-treatment control group to evaluate the safety and therapeutic effect of stromal vascular fraction therapy for human knee osteoarthritis. We have also established a novel protocol to provide 3D MRI imaging for human knee cartilage enabling us to qualitatively and quantitatively evaluate cartilage degeneration and regeneration in this study. Results: The qualitative and quantitative evaluation of 3D Magnetic Resonance Imaging (MRI) imaging of knee cartilage demonstrated that the stromal vascular fraction therapy reduced the cartilage defects; and significant increase of cartilage value both in defect cartilage area and whole cartilage area of treated group and significant increase of thickness and area of both femoral and tibia cartilage in vertical sections of the stromal vascular fraction treated Group at 12 and 24 W post treatment in cartilage defect I-II osteoarthritis patients. Conclusion: This clinical phase I/II study indicated that stromal vascular fraction therapy is a safe clinical procedure and provided evidence that the stromal vascular fraction therapy significantly facilitated cartilage regeneration, opening the opportunity to a phase III trial investigating authentic efficacy of the procedure. This study is the first qualitative and quantitative evaluation of the efficacy of autologous stromal vascular fraction cellular therapy on cartilage regeneration. Through early and definite diagnosis of knee osteoarthritis patients, and providing safe and efficient therapy to facilitate cartilage regeneration, we will be able to control or reverse cartilage degeneration and completely change the epidemiology of osteoarthritis worldwide.
    Type of Medium: Online Resource
    ISSN: 2296-634X
    URL: Article
    DOI: 10.3389/fcell.2023.1106279
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2737824-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Energy Management and Operational Planning of an Ecological Engineering for Carbon Sequestration in Coastal Mariculture Environments in China
    MDPI AG ; 2019
    In:  Sustainability Vol. 11, No. 11 ( 2019-06-05), p. 3162-
    Details
    In: Sustainability, MDPI AG, Vol. 11, No. 11 ( 2019-06-05), p. 3162-
    Abstract: China is now accelerating the development of an ecological engineering for carbon sequestration in coastal mariculture environments to cope with climate change. Artificial upwelling as the ecological engineering can mix surface water with bottom water and bring rich nutrients to the euphotic zone, enhance seaweed growth in the oligotrophic sea area, and then increase coastal carbon sequestration. However, one of the major obstacles of the artificial upwelling is the high energy consumption. This study focused on the development of energy management technology for air-lift artificial upwelling by optimizing air injection rate. The fundamental principle underlying this technology is that the mode and intensity of air injection are adjusted from the feedback of information on velocity variation in tidal currents, illumination, and temperature of the surface layer. A series of equations to control air injection was derived based on seaweed growth and solar power generation. Although this finding was originally developed for the air-lift artificial upwelling, it also can be used in other areas of engineering, such as water delivery, aeration, and oxygenation. The simulations show that using a variable air injection rate can lift more nitrogen nutrients of 28.2 mol than using a fixed air injection rate of 26.6 mol, mostly with the same energy cost. Using this control algorithm, the changed temperature and dissolved oxygen profiles prove the effective upwelling in the experiments and the average weights of kelp are 33.1 g in the experimental group and 10.1 g in the control group. The ecological engineering was successfully increasing crop yield for carbon sequestration in coastal mariculture environments.
    Type of Medium: Online Resource
    ISSN: 2071-1050
    URL: Article
    DOI: 10.3390/su11113162
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2518383-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...