In:
The Journal of Immunology, The American Association of Immunologists, Vol. 200, No. 1_Supplement ( 2018-05-01), p. 182.35-182.35
Abstract:
Human immunodeficiency virus type 1 (HIV-1)/simian immunodeficiency virus (SIV) infection causes a progressive impairment of the immune system characterized by massive CD4+ T-cell loss, CD8+ T-cell expansion and sustained immune activation and inflammation. Our data also suggest that pathogenic SIVMAC251 infection in rhesus macaques (RMs) leads to decreased production of several T-helper 1 (TH1) and TH2 cytokines and increased production of IL-17, IFNg, CCL4 and GM-CSF by intestinal CD8+ T-cells 21 days after infection. For an effective T-cell activation and response, costimulation is required in addition to the antigen-specific signal from their antigen receptors. The CD2/CD58 interaction is considered as one of the important T-cell costimulatory pathway for T-cell activation and proliferation. Intestinal lamina propria T cells were reported to be highly responsive to a stimulus delivered by CD2 pathway compared to the conventional CD3/TCR pathway. The role of CD2/CD58 in regulating intestinal T-cell function of acute and chronic SIV infected RMs is poorly documented. Here, we demonstrated a significant reduction of CD58 expression in both T- and B-cell population during acute SIV infection along with the loss of intestinal CD4+ T-cells and high plasma viral load compared to SIV-uninfected normal RMs. The reduction of CD58 expression in T-cells was positively correlated with the reduced expression of T-cell mediated IL2 and TNFa production. Together, these results indicate that the reduction in CD2/CD58 interaction pathway in mucosal lymphocytes might play a crucial role in mucosal T-cell dysfunction during acute SIV/HIV infection.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.200.Supp.182.35
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2018
detail.hit.zdb_id:
1475085-5
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