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  • 1
    Online-Ressource
    Online-Ressource
    Seroprevalence of Toxoplasma gondii infection among women of childbearing age in an endemic region of Romania, 2016–2018
    EDP Sciences ; 2020
    In:  Parasite Vol. 27 ( 2020), p. 59-
    Details
    In: Parasite, EDP Sciences, Vol. 27 ( 2020), p. 59-
    Kurzfassung: La toxoplasmose est une zoonose mondiale importante causée par le parasite protozoaire Toxoplasma gondii . Cette infection parasitaire est souvent asymptomatique chez les sujets immunocompétents. Cependant, si l’infection survient chez la femme enceinte, elle peut avoir de graves conséquences pour le fœtus. Dans cette étude, nous avons évalué la séroprévalence de T. gondii chez les femmes en âge de procréer dans le comté d’Arad, dans l’ouest de la Roumanie. Des échantillons de sérum de 2626 femmes ont été analysés avec le Siemens ADVIA Centaur XP. Des anticorps IgG contre T. gondii ont été mis en évidence chez 1081 femmes (41 %) et la prévalence avait tendance à augmenter avec l’âge, passant de 32 % chez les femmes âgées de 15 à 19 ans à 62 % chez les femmes âgées de 40 à 45 ans. La prévalence était plus élevée dans les zones rurales (46 %) que dans les zones urbaines (36 %). Cette étude fournit de nouvelles données sur la séroprévalence de T. gondii chez les femmes en âge de procréer de l’ouest de la Roumanie.
    Materialart: Online-Ressource
    ISSN: 1776-1042
    URL: Article
    DOI: 10.1051/parasite/2020057
    Sprache: Englisch
    Verlag: EDP Sciences
    Publikationsdatum: 2020
    ZDB Id: 2278575-9
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Seroprevalence of Anti-Echinococcus granulosus Antibodies and Risk Factors for Infection in Blood Donors from Western Romania
    MDPI AG ; 2023
    In:  Life Vol. 13, No. 4 ( 2023-03-24), p. 871-
    Details
    In: Life, MDPI AG, Vol. 13, No. 4 ( 2023-03-24), p. 871-
    Kurzfassung: Cystic echinococcosis is a worldwide-distributed zoonotic parasitic disease. This cross-sectional study aimed to assess the seroprevalence and risk factors potentially associated with Echinococcus granulosus in healthy blood donors from Timis County, an endemic region in Western Romania. Serum samples were collected from 1347 Romanian blood donors. Serologic tests to determine the presence of anti-Echinococcus antibodies were performed using an anti-Echinococcus-ELISA immunoassay. Anti-Echinococcus antibodies were detected in 38 blood donors, indicating an overall seroprevalence of 2.8%. The seropositivity rate was 3.7% in females and 3.1% in blood donors residing in urban areas. The highest seropositivity was found in the age group of 31–40 years (3.6%). There were no significant differences between Echinococcus seropositivity and gender, area of residence, age, contact with dogs, or raising sheep. This serologic survey evaluated for the first time the presence of Echinococcus antibodies in healthy blood donors from Western Romania and the potential risk factors associated with echinococcosis. Our results suggest that this zoonotic infection might evolve asymptomatically in apparently healthy individuals. Further studies should be conducted in the general population to estimate the true extent of human echinococcosis and its risk factors.
    Materialart: Online-Ressource
    ISSN: 2075-1729
    URL: Article
    DOI: 10.3390/life13040871
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2023
    ZDB Id: 2662250-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
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    Seroepidemiology of Toxoplasma gondii Infection in Blood Donors from Western Romania
    MDPI AG ; 2022
    In:  Microorganisms Vol. 10, No. 5 ( 2022-05-05), p. 973-
    Details
    In: Microorganisms, MDPI AG, Vol. 10, No. 5 ( 2022-05-05), p. 973-
    Kurzfassung: Background: Toxoplasma gondii is estimated to infect 33% of blood donors worldwide, and seroprevalence varies widely between countries. We aimed to evaluate, for the first time, the seroprevalence and risk factors associated with T. gondii in blood donors from Western Romania. Methods: Serologic testing to demonstrate the presence of T. gondii antibodies was conducted in 1347 healthy blood donors. Risk factors for T. gondii infection were assessed through an epidemiological questionnaire. Results: The overall prevalence of T. gondii antibodies was 45.9%, with a significant age-associated increase (p 〈 0.001) from 32.6% in age group 18–25 years to 67.6% in age group 56–63 years. T. gondii seroprevalence decreased with increasing level of education, from 64.3% in individuals who graduated from elementary/middle school to 40.4% in those who graduated from University (p 〈 0.001). The multiple logistic regression analysis revealed that age, level of education and having pets (cats and/or dogs) were significantly associated with T. gondii infection. Conclusions: This study brings new and valuable data regarding the seroepidemiology of T. gondii infection in Romania. Our findings indicate a high prevalence of T. gondii antibodies in blood donors and may serve as a starting point for further epidemiological studies that should lead to implementation of prevention programs for toxoplasmosis.
    Materialart: Online-Ressource
    ISSN: 2076-2607
    URL: Article
    DOI: 10.3390/microorganisms10050973
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2720891-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Online-Ressource
    Online-Ressource
    Seroprevalence of SARS-CoV-2 antibodies in 2115 blood donors from Romania
    Elsevier BV ; 2021
    In:  Clinical Microbiology and Infection Vol. 27, No. 5 ( 2021-05), p. 817-819
    Details
    In: Clinical Microbiology and Infection, Elsevier BV, Vol. 27, No. 5 ( 2021-05), p. 817-819
    Materialart: Online-Ressource
    ISSN: 1198-743X
    URL: Article
    DOI: 10.1016/j.cmi.2020.12.027
    Sprache: Englisch
    Verlag: Elsevier BV
    Publikationsdatum: 2021
    ZDB Id: 2020034-1
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Toxoplasma gondii Infection in Patients with Cardiovascular Diseases from Western Romania: A Case–Control Study
    MDPI AG ; 2023
    In:  Life Vol. 13, No. 7 ( 2023-07-17), p. 1575-
    Details
    In: Life, MDPI AG, Vol. 13, No. 7 ( 2023-07-17), p. 1575-
    Kurzfassung: (1) Background: Toxoplasma gondii infects approximately one third of the world’s human population. The seroepidemiology of T. gondii in cardiovascular patients is poorly discussed in the existing literature. We aimed to evaluate, for the first time, the seroprevalence of T. gondii in cardiovascular patients from Western Romania. (2) Methods: Serologic testing to demonstrate the presence of T. gondii antibodies was conducted in 256 patients with cardiovascular diseases and 261 matched blood donors. (3) Results: The overall seroprevalence of T. gondii antibodies was 64.06% in patients with cardiovascular diseases and 52.88% in blood donors and tended to increase with age in both groups. The seroprevalence of T. gondii antibodies was significantly higher in cardiovascular male patients (69.94%) compared to male blood donors (55.69%) (p = 0.006). When compared to the control group, a significantly higher prevalence of T. gondii antibodies was found among patients with hypertension (82.35%; p = 0.01) and unstable angina (67.56%; p = 0.02). (4) Conclusions: This study brings new epidemiological information on the prevalence of T. gondii in Romanian cardiovascular patients. T. gondii seroprevalence was significantly higher in patients with hypertension and unstable angina, suggesting that individuals with these diagnoses may be more frequently infected with T. gondii. This study may be a valuable starting point for further research to better evaluate the impact of T. gondii exposure on patients with cardiovascular diseases.
    Materialart: Online-Ressource
    ISSN: 2075-1729
    URL: Article
    DOI: 10.3390/life13071575
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2023
    ZDB Id: 2662250-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
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    Cystic Echinococcosis in Hospitalized Adult Patients from Western Romania: 2007–2022
    MDPI AG ; 2023
    In:  Microorganisms Vol. 11, No. 10 ( 2023-09-25), p. 2388-
    Details
    In: Microorganisms, MDPI AG, Vol. 11, No. 10 ( 2023-09-25), p. 2388-
    Kurzfassung: Cystic echinococcosis (CE) is a neglected parasitic disease caused by the tapeworm Echinococcus granulosus. The aim of this study was to assess the epidemiological features of human cystic echinococcosis in patients from Western Romania. We retrospectively investigated the medical records of patients hospitalized with CE between 1 January 2007 and 1 September 2022. A total of 366 patients (range 18–90 years) were recorded. The number of hospitalized individuals was higher in patients aged 50–59 years (83/366, 22.7%), in females (194/366, 53%), and in residents of rural areas (225/366, 61.5%). The liver was the most common localization of the cysts (302/366, 82.5%). Ninety-eight patients (26.8%) presented complications, including biliary fistula, allergies, and infection of the cyst. Patients with complications had a longer mean hospital stay (15.7 ± 8.3 days) compared to patients without complications (11.5 ± 7.3 days) (p 〈 0.001). The results of this study revealed that patients diagnosed with CE required hospitalization and extended medical care, indicating that this zoonotic disease remains a significant public health problem in Western Romania. Public health authorities should enhance CE surveillance by implementing control programs and mandatory notification of new cases.
    Materialart: Online-Ressource
    ISSN: 2076-2607
    URL: Article
    DOI: 10.3390/microorganisms11102388
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2023
    ZDB Id: 2720891-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
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    Epidemiology of Cryptosporidium Infection in Romania: A Review
    MDPI AG ; 2023
    In:  Microorganisms Vol. 11, No. 7 ( 2023-07-12), p. 1793-
    Details
    In: Microorganisms, MDPI AG, Vol. 11, No. 7 ( 2023-07-12), p. 1793-
    Kurzfassung: Since 1983, when the first report of a human Cryptosporidium spp. infection was published in Romania, and until now, many studies on cryptosporidiosis have been published in our country, but most of them are in the Romanian language and in national journals less accessible to international scientific databases. Although the infection was first recognized as a problem in children or immunocompromised people or more of a problem in low-income or underdeveloped global countries, we have shown in this review that it can also occur in people with normal immunological function and that the epidemiology of our country can provide a theoretical basis for the formulation of a Cryptosporidium spp. prevention strategy. In addition, 9.1% of healthy children and 73% of immunocompromised children were observed to have Cryptosporidium spp. infections. Higher rates have also been reported in immunocompromised adults (1.8–50%). Analyzing the prevalence of Cryptosporidium spp. infection in animals, we found values of 28.52% in cattle, 18% in buffalo calves, between 27.8 and 60.4% in pigs, 52.7% in dogs, and 29.4% in cats. Furthermore, in Romania, the burden of cryptosporidiosis, including acute infections and long-term sequelae, is currently unknown.
    Materialart: Online-Ressource
    ISSN: 2076-2607
    URL: Article
    DOI: 10.3390/microorganisms11071793
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2023
    ZDB Id: 2720891-6
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    Seroprevalence and Risk Factors of Trichinella spiralis Infection in Blood Donors from Western Romania
    MDPI AG ; 2022
    In:  Medicina Vol. 58, No. 1 ( 2022-01-15), p. 128-
    Details
    In: Medicina, MDPI AG, Vol. 58, No. 1 ( 2022-01-15), p. 128-
    Kurzfassung: Background and Objectives: Trichinellosis, a serious and sometimes fatal human disease, is a foodborne zoonotic disease with worldwide distribution caused by parasitic nematodes of the genus Trichinella. Humans are infected with Trichinella larvae through the ingestion of meat that has not been properly cooked. Romania reported most of the confirmed cases of trichinellosis among the EU countries. The aim of this cross-sectional study was to evaluate, for the first time, the seroprevalence and risk factors of Trichinella infection in blood donors from Western Romania. Materials and Methods: Serum samples of 1347 consecutive blood donors were investigated using an immunoenzymaticassay (ELISA) for the determination of specific IgG class antibodies against T.spiralis. A questionnaire interview was used to obtain information regarding the potential risk factors associated with T. spiralis infection. Mantel–Haenszel chi-squared test or the Fisher exact two-tailed test, as appropriate, were used for comparison between T. spiralis positive and T. spiralis negative blood donors. Student’s t-test was used to evaluate differences between means in studied groups and body mass index was calculated by dividing weight in kilograms by height in meters squared. Statistical analysis was performed using Epi Info Version 7.2 and Stata 16.1. Results: T. spiralis IgG antibodies were detected in 2.00% (27) of 1347 consecutive blood donors. Eating raw and/or undercooked meat, from pigs or wild boars, was found to be the main risk factor (p 〈 0.001). Strong alcoholic drink consumption was highly associated with T. spiralis infection (p = 0.009). Trichinella seroprevalence was higher among rural residents and males. Subjects identified as Trichinella seropositive were not previously diagnosed and have not been treated for Trichinella infection with any specific therapy. Conclusions: The demonstration of T. spiralis antibodies in healthy blood donors suggests that Trichinella infection may be detected in asymptomatic individuals that were not previously diagnosed with this zoonosis.
    Materialart: Online-Ressource
    ISSN: 1648-9144
    URL: Article
    DOI: 10.3390/medicina58010128
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2088820-X
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    A Review of Digital Health and Biotelemetry: Modern Approaches towards Personalized Medicine and Remote Health Assessment
    MDPI AG ; 2022
    In:  Journal of Personalized Medicine Vol. 12, No. 10 ( 2022-10-05), p. 1656-
    Details
    In: Journal of Personalized Medicine, MDPI AG, Vol. 12, No. 10 ( 2022-10-05), p. 1656-
    Kurzfassung: With the prevalence of digitalization in all aspects of modern society, health assessment is becoming digital too. Taking advantage of the most recent technological advances and approaching medicine from an interdisciplinary perspective has allowed for important progress in healthcare services. Digital health technologies and biotelemetry devices have been more extensively employed for preventing, detecting, diagnosing, monitoring, and predicting the evolution of various diseases, without requiring wires, invasive procedures, or face-to-face interaction with medical personnel. This paper aims to review the concepts correlated to digital health, classify and describe biotelemetry devices, and present the potential of digitalization for remote health assessment, the transition to personalized medicine, and the streamlining of clinical trials.
    Materialart: Online-Ressource
    ISSN: 2075-4426
    URL: Article
    DOI: 10.3390/jpm12101656
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2022
    ZDB Id: 2662248-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Patterns and Factors Associated with Self-Medication among the Pediatric Population in Romania
    MDPI AG ; 2020
    In:  Medicina Vol. 56, No. 6 ( 2020-06-25), p. 312-
    Details
    In: Medicina, MDPI AG, Vol. 56, No. 6 ( 2020-06-25), p. 312-
    Kurzfassung: Background and objectives: Self-medication is a global phenomenon in both developed and emerging countries. At present, data regarding the practice, patterns, and factors associated with self-medication in Romanian patient groups of various ages and health are relatively scarce. A pilot study that uses a questionnaire was conducted to observe the attitudes as well as the behaviors of a group of Romanian parents related to self-medication, specifically their beliefs and perceived risks of the administration of medicine to their children without medical advice, frequency of self-medications, symptoms, and types of medications most commonly used without medical advice. Materials and Methods: The questionnaire was sent via e-mail or WhatsApp link on a mobile phone using the existing data at the general practitioner’s office together with the protection of data form and the informed consent form; some participants completed the questionnaire when they came for a regular visit at the general practitioner’s office. Of 246 applied questionnaires, we had a rate of responses of 98%. Results: We found a high percentage (70%) of parents who self-medicate their children. The data reveals a significant relation between parents’ beliefs on self-medication and their tendency to administrate drugs to their children without medical advice. A significant relation was also found between the likelihood of parental self-medication for their children and the number of illnesses experienced by their children over the six-month period prior to the survey. Even when parents have a correct understanding of self-medication risks, these are not aligned with actual behavior; therefore, parents continue to administer drugs to their children without medical advice. Conclusions: Our study helps to describe the patterns of parents’ decisions about self-medicating their children and to identify parents who are more predisposed to administering self-medication to their children.
    Materialart: Online-Ressource
    ISSN: 1648-9144
    URL: Article
    DOI: 10.3390/medicina56060312
    Sprache: Englisch
    Verlag: MDPI AG
    Publikationsdatum: 2020
    ZDB Id: 2088820-X
    Standort Signatur Einschränkungen Verfügbarkeit
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