In:
Frontiers in Pharmacology, Frontiers Media SA, Vol. 12 ( 2022-1-18)
Abstract:
Background: The lack of the recovery of CD4 + T-cells (CD4 + recovery) among immunodeficiency virus (HIV)-infected patients on antiretroviral therapy (ART) is not well known. We aimed to analyze the association between single nucleotide polymorphisms (SNPs) underlying vitamin D metabolism and the CD4 + recovery in naïve HIV-infected patients who started ART with low baseline CD4 + . Methods: We conducted a retrospective study in 411 naïve individuals with plasma HIV load & gt;200 copies/mL and CD4 + & lt;200 cells/mm 3 . During 24 months of follow-up, all patients had plasma HIV load & lt;50 copies/mL. DNA genotyping was performed using the Sequenom MassARRAY platform. The outcome variable was the change in CD4 + during the study. Results: CD4 + recovery was higher in patients carrying DBP rs7041 AA genotype (AA versus CC/AC) and DHCR7 rs3829251 AA genotype (AA versus GG/AG) ( p -value & lt; 0.05). DBP rs7041 AA genotype was linked to increase in CD4 + (adjusted arithmetic mean ratio (aAMR) = 1.22; q -value = 0.011), increase in CD4 + ≥P75th [adjusted odds ratio (aOR) = 2.31; q -value = 0.005], slope of CD4 + recovery (aAMR = 1.25; q -value = 0.008), slope of CD4 + recovery ≥ P75th (aOR = 2.55; q -value = 0.005) and achievement of CD4 + ≥500 cells/mm 3 (aOR = 1.89; q -value = 0.023). Besides, DHCR7 rs3829251 AA genotype was related to increase in CD4 + (aAMR = 1.43; q -value = 0.031), increase in CD4 + ≥P75th (aOR = 3.92; q -value = 0.030), slope of CD4 + recovery (aAMR = 1.40; q -value = 0.036), slope of CD4 + recovery ≥ P75th (aOR = 3.42; q -value = 0.031) and achievement of CD4 + ≥500 cells/mm 3 (aOR = 5.68; q -value = 0.015). Conclusion: In summary, DHCR7 rs3829251 and DBP rs7041 polymorphisms were associated with CD4 + recovery in HIV-infected patients who started cART with low CD4 + T-cell counts.
Type of Medium:
Online Resource
ISSN:
1663-9812
DOI:
10.3389/fphar.2021.773848
DOI:
10.3389/fphar.2021.773848.s001
DOI:
10.3389/fphar.2021.773848.s002
DOI:
10.3389/fphar.2021.773848.s003
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2587355-6
SSG:
15,3
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