In:
EMBO reports, EMBO, Vol. 21, No. 12 ( 2020-12-03)
Abstract:
image Inhibition of mitochondrial pyruvate import in brown adipocytes activates lipid cycling and increases energy expenditure even in the absence of adrenergic stimulation. In the absence of mitochondrial pyruvate entry, the TCA cycle receives carbons from glutamine to support beta‐oxidation. Genetic and pharmacological targeting of the mitochondrial pyruvate carrier (MPC) activates lipolysis and shifts metabolism towards fatty acid utilization. The activation of lipolysis induces an energy demanding cycle of esterification and triglyceride breakdown. The increase in energy expenditure is supported by glutamine oxidation and the activation of the malate‐aspartate shuttle.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.201949634
Language:
English
Publisher:
EMBO
Publication Date:
2020
detail.hit.zdb_id:
2025376-X
SSG:
12
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