In:
British Journal of Pharmacology, Wiley, Vol. 113, No. 4 ( 1994-12), p. 1231-1236
Abstract:
The effects of chronic treatments with a selective β 3 ‐adrenoceptor agonist and a selective α 2 ‐adrenoceptor antagonist and their interactions with physical exercise training were studied in experimental obesity. BRL 35135 (β 3 ‐agonist, 0.5 mg kg −1 day −1 p.o.), atipamezole (α 2 ‐antagonist, 4.0 mg kg −1 day −1 p.o.) and placebo were given to genetically obese male Zucker rats. Half of the rats were kept sedentary whereas the other half were subjected to moderate treadmill exercise training. Body weight gain, cumulative food intake, the neuropeptide Y content of the hypothalamic paraventricular nucleus, brown adipose tissue thermogenic activity (measured as GDP binding), plasma insulin and glucose levels were measured after 3 weeks' treatment and exercise. Treatment with BRL 35135 reduced weight gain by 19%, increased brown adipose tissue thermogenic activity 45‐fold and reduced plasma insulin by 50%. Atipamezole slightly increased food intake and neuropeptide Y content in the paraventricular hypothalamic nucleus but had no effect on the other measured parameters. Exercise alone had no effect on weight gain, food intake or thermogenic activity, whereas it reduced plasma insulin and glucose levels. The effect of BRL 35135 on weight gain and thermogenic activity was significantly potentiated by exercise; the reduction in weight gain was 56% in comparison with 19% in sedentary animals. Food intake was significantly reduced in the BRL 35135‐treated‐exercise‐trained animals, although neither β 3 ‐agonist nor exercise alone affected it. Based on the present results in genetically obese Zucker rats, combination of β 3 ‐agonist treatment with a moderate physical training may offer a new feasible approach to the therapy of obesity.
Type of Medium:
Online Resource
ISSN:
0007-1188
,
1476-5381
DOI:
10.1111/bph.1994.113.issue-4
DOI:
10.1111/j.1476-5381.1994.tb17129.x
Language:
English
Publisher:
Wiley
Publication Date:
1994
detail.hit.zdb_id:
80081-8
detail.hit.zdb_id:
2029728-2
SSG:
15,3
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