In:
European Journal of Organic Chemistry, Wiley, Vol. 2020, No. 40 ( 2020-10-31), p. 6375-6381
Abstract:
[ 18 F]Fluoroaliphatic carboxylic acids are important PET tracers that have demonstrated a considerable potential to address the fatty acid oxidation‐dependent processes in clinical patients. Herein, we report an efficient radiosynthetic approach to ω‐[ 18 F]fluoroaliphatic carboxylic esters and acids by nucleophilic radiofluorination of the readily available iodocarboxylic esters. Methyl 6‐[ 18 F]fluorohexanoate was further applied as a starting material for the preparation of the succinimide ester (NHS ester)‐containing bifunctional radiofluorinated prosthetic group in two simple steps, 10 min each. The synthesized NHS ester of 6‐[ 18 F]fluorohexanoic acid can serve as an important reagent for a quick and efficient conjugation with peptides or proteins via amino groups of lysines.
Type of Medium:
Online Resource
ISSN:
1434-193X
,
1099-0690
DOI:
10.1002/ejoc.v2020.40
DOI:
10.1002/ejoc.202000934
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
1475010-7
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