In:
Pediatric Allergy and Immunology, Wiley, Vol. 26, No. 4 ( 2015-06), p. 316-322
Abstract:
Children with cow's milk allergy ( CMA ) are at risk for inadequate nutritional intake and growth. Dietary management of CMA , therefore, requires diets that are not only hypoallergenic but also support adequate growth in this population. This study assessed growth of CMA infants when using a new amino acid‐based formula ( AAF ) with prebiotics and probiotics (synbiotics) and evaluated its safety in the intended population. Methods In a prospective, randomized, double‐blind controlled study, full‐term infants with diagnosed CMA received either an AAF (control; n = 56) or AAF with synbiotics (oligofructose, long‐chain inulin, acidic oligosaccharides, Bifidobacterium breve M‐16V) (test; n = 54) for 16 wk. Primary outcome was growth, measured as weight, length and head circumference. Secondary outcomes included allergic symptoms and stool characteristics. Results Average age (± SD ) of infants at inclusion was 4.5 ± 2.4 months. Both formulas equally supported growth according to WHO 2006 growth charts and resulted in similar increases of weight, length and head circumference. At week 16, differences (90% CI ) in Z ‐scores (test–control) were as follows: weight 0.147 (−0.10; 0.39, p = 0.32), length −0.299 (−0.69; 0.09, p = 0.21) and head circumference 0.152 (−0.15; 0.45, p = 0.40). Weight‐for‐age and length‐for‐age Z ‐scores were not significantly different between the test and control groups. Both formulas were well tolerated and reduced allergic symptoms; the number of adverse events was not different between the groups. Conclusions This is the first study that shows that an AAF with a specific synbiotic blend, suitable for CMA infants, supports normal growth and growth similar to the AAF without synbiotics. This clinical trial is registered as NCT 00664768.
Type of Medium:
Online Resource
ISSN:
0905-6157
,
1399-3038
DOI:
10.1111/pai.2015.26.issue-4
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2008584-9
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