In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 10 ( 2021-10-25), p. e1009928-
Abstract:
Non-specific protective effects of certain vaccines have been reported, and long-term boosting of innate immunity, termed trained immunity , has been proposed as one of the mechanisms mediating these effects. Several epidemiological studies suggested cross-protection between influenza vaccination and COVID-19. In a large academic Dutch hospital, we found that SARS-CoV-2 infection was less common among employees who had received a previous influenza vaccination: relative risk reductions of 37% and 49% were observed following influenza vaccination during the first and second COVID-19 waves, respectively. The quadrivalent inactivated influenza vaccine induced a trained immunity program that boosted innate immune responses against various viral stimuli and fine-tuned the anti-SARS-CoV-2 response, which may result in better protection against COVID-19. Influenza vaccination led to transcriptional reprogramming of monocytes and reduced systemic inflammation. These epidemiological and immunological data argue for potential benefits of influenza vaccination against COVID-19, and future randomized trials are warranted to test this possibility.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1009928
DOI:
10.1371/journal.ppat.1009928.g001
DOI:
10.1371/journal.ppat.1009928.g002
DOI:
10.1371/journal.ppat.1009928.g003
DOI:
10.1371/journal.ppat.1009928.g004
DOI:
10.1371/journal.ppat.1009928.g005
DOI:
10.1371/journal.ppat.1009928.t001
DOI:
10.1371/journal.ppat.1009928.s001
DOI:
10.1371/journal.ppat.1009928.s002
DOI:
10.1371/journal.ppat.1009928.s003
DOI:
10.1371/journal.ppat.1009928.s004
DOI:
10.1371/journal.ppat.1009928.s005
DOI:
10.1371/journal.ppat.1009928.s006
DOI:
10.1371/journal.ppat.1009928.s007
DOI:
10.1371/journal.ppat.1009928.r001
DOI:
10.1371/journal.ppat.1009928.r002
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2205412-1
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