In:
Dermatology, S. Karger AG, Vol. 224, No. 3 ( 2012), p. 236-243
Kurzfassung:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Large disease registries are the preferred method to assess long-term treatment safety. If psoriasis registries collaborate in a network, their power to assess safety is increased. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To identify heterogeneity in psoriasis registries and methodological challenges for synthesising the data they provide. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We surveyed the registries in PSONET and identified and addressed the challenges to collaborative analysis for the network in several round table meetings. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Eight out of 10 registries had a prospective comparator cohort with similar disease characteristics but not on biologics. Registries differed in the coding and validation or follow-up of adverse events and in the way they sampled their population. Fifteen challenges to registries collaborating were identified in the areas of operational governance, structural conduct, bias and analysis. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Participation in PSONET, a network of psoriasis registries, helps identify and solve common issues, enhancing the individual registries, and provides larger sets of more powerful safety data in a diverse population. Challenges to interpreting data collectively include heterogeneity in sampling, variable penetration of biologics and compatibility of different datasets.
Materialart:
Online-Ressource
ISSN:
1018-8665
,
1421-9832
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2012
ZDB Id:
1482189-8
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