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  • 1
    Online Resource
    Online Resource
    Elsevier BV ; 2022
    In:  American Journal of Otolaryngology Vol. 43, No. 4 ( 2022-07), p. 103510-
    In: American Journal of Otolaryngology, Elsevier BV, Vol. 43, No. 4 ( 2022-07), p. 103510-
    Type of Medium: Online Resource
    ISSN: 0196-0709
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 2041649-0
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  • 2
    Online Resource
    Online Resource
    American Association for Cancer Research (AACR) ; 2020
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 29, No. 12_Supplement ( 2020-12-01), p. PO-044-PO-044
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 29, No. 12_Supplement ( 2020-12-01), p. PO-044-PO-044
    Abstract: Introduction: The authors examined feasible mechanisms for a cancer research lab at a university to improve racial/cultural cancer disparities issues in Minneapolis/St. Paul, Minnesota. The goal was to find tangible mechanisms to preliminarily and proactively attend to racial disparities issues based on recent events in our community. Materials and Methods: The authors identified four domains of activity that could potentially be deployed to the local Black community. These consisted of improved community education, improved health care access, improved researcher education about racism/cultural bias, and education on the concept of trauma informed care. Community cancer education outreach was judged most feasible program’s researchers. In the past, education outreach had been performed at K-8 school science fairs and a community cancer education program where we have been instructors (an entity called Mini-medical school). Demographics for past interactions were analyzed to gauge directing further outreach. Results: In the Twin cities proper 16-19% of the residents are Black (Primarily African American and Somali); in the larger metropolitan area 8-9%, and 6-7% overall in Minnesota. We found that our research program outreach had occurred at a school with only 4.4% Black/African American students. At the larger Cancer education program (Mini medical school), approximately 3.5% of attendees were African American. Both of these outreach activities occurred in communities with much lower percentage than the 16-19% Black community demographic (P & lt;0.001). Discussion: We plan to contact primary schools in local communities of color where we can participate at science or technology fairs as educators/judges based on our scientific expertise. Further, through these local schools and their communities, Cancer disparities education (such as the mini-medical school) could be tailored to neighborhood school communities as part of this outreach. The authors felt participation in this activity by Black physicians/scientists/students, inexpensive access, and maximizing student/family availability for the program would be necessary to optimize the experience. We conclude that such a grass root pilot would provide useful education for the community, perhaps improve cancer research interests in primary grade students, and could feasibly be extended to additional cancer research labs at our university, based on the results of a 1-2 school pilot effort. Citation Format: Juliana M. Ondrey, Frank Ondrey. A pilot concept for cancer education outreach to community K-8 schools [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-044.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2020
    detail.hit.zdb_id: 2036781-8
    detail.hit.zdb_id: 1153420-5
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  • 3
    Online Resource
    Online Resource
    Wiley ; 2000
    In:  The Laryngoscope Vol. 110, No. 2 ( 2000-02), p. 217-217
    In: The Laryngoscope, Wiley, Vol. 110, No. 2 ( 2000-02), p. 217-217
    Abstract: Background: Otologic structures are often contained within head and neck cancer radiation treatment ports. The dosimetry to otologic structures has not been routinely analyzed and radiation treatment planning does not currently attempt to specifically avoid the inner ear structures when dosimetry is calculated. Recent studies demonstrate that up to 30% of patients experience sensorineural hearing loss on multimodality therapy with cisplatin and radiation. Methods: In the current case series, radiation dosimetry to otologic structures was calculated from computed tomogram treatment plans on patients. Fifteen nasopharyngeal, oral cavity, oropharyngeal, and hypopharyngeal cancer patients were analyzed. Results: Between 8% and 102% of the total dose is delivered to the petrous bone/cochlea, with 4 of 15 patients getting more than 50% of the dose to at least one cochlea. The mastoid air cells received between 3% and 75% of the total dose, with higher doses being delivered to patients with bulky high neck metastases or nasopharyngeal tumors. The eustachian tubes received between 2% and 102% of the total dose, with 10 of 15 patients receiving more than 50% of the dose to this anatomic site. Conclusion: We conclude that the cochlea and eustachian tubes receive significant radiation during treatment, particularly in nasopharyngeal cancer patients. Careful design of radiation treatment ports may allow for the reduction of radiation to hearing structures.
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    Language: English
    Publisher: Wiley
    Publication Date: 2000
    detail.hit.zdb_id: 2026089-1
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  • 4
    In: The Laryngoscope, Wiley, Vol. 121, No. 2 ( 2011-02), p. 372-374
    Type of Medium: Online Resource
    ISSN: 0023-852X
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 2026089-1
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  • 5
    Online Resource
    Online Resource
    Wiley ; 1996
    In:  The Laryngoscope Vol. 106, No. 2 ( 1996-02), p. 129-134
    In: The Laryngoscope, Wiley, Vol. 106, No. 2 ( 1996-02), p. 129-134
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    Language: English
    Publisher: Wiley
    Publication Date: 1996
    detail.hit.zdb_id: 2026089-1
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  • 6
    Online Resource
    Online Resource
    Wiley ; 2008
    In:  The Laryngoscope Vol. 118, No. 8 ( 2008-08), p. 1395-1399
    In: The Laryngoscope, Wiley, Vol. 118, No. 8 ( 2008-08), p. 1395-1399
    Abstract: Objectives/Hypothesis: It is well known that invasion is a seminal event in the progression of oral and other head and neck carcinoma sites. We have previously demonstrated tumor necrosis factor (TNF)‐α and its dependent cytokines are upregulated in saliva during oral carcinogenesis. TNF‐dependent events stimulate nuclear factor (NF)‐κB and many NF‐κB‐dependent genes are associated with cancer progression. Materials and Methods: In the present study, we examined NF‐κB stimulation of matrix metalloproteinase (MMP)‐9 in a precancerous keratinocyte cell line that models leukoplakia (Rhek cells). We stimulated Rhek cells with both TNF‐α and phorbol myristate acetate, known stimulants of NF‐κB. We then assayed MMP‐9 transcription and secretion by luciferase reporter genes, quantitative real‐time polymerase chain reaction, and fluorometric enzyme‐linked immunosorbent serologic assay. Results: We discovered that the MMP‐9 promoter was significantly stimulated by phorbol myristate acetate and TNF‐α on luciferase reporter gene assays. Further, we uncovered that functional MMP‐9 promoter activation was accompanied by significant increases in MMP‐9 gene expression, as judged by quantitative real‐time polymerase chain reaction 〈 !—AQ1: Per style, genes are set italic while proteins are roman. Please underline genes.— 〉 . Functional activation of the MMP‐9 protein was stimulated by TNF‐α and PMA on a fluorescent enzyme‐linked immunosorbent serologic assay. Finally, we searched our salivary proteomic database for increases in MMP‐9 and discovered it was the third most significant protein in salivas of oral cavity cancer patients over normal controls. Conclusions: We conclude the milieu cytokine, TNF‐α, has the capacity to provide stimulation of events related to early invasion of oral cavity cancer, as judged by its ability to stimulate MMP‐9.
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2026089-1
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  • 7
    Online Resource
    Online Resource
    Wiley ; 2009
    In:  The Laryngoscope Vol. 119, No. S3 ( 2009-01)
    In: The Laryngoscope, Wiley, Vol. 119, No. S3 ( 2009-01)
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 2026089-1
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  • 8
    In: The Laryngoscope, Wiley, Vol. 116, No. 10 ( 2006-10), p. 1873-1876
    Abstract: Background: Vogt‐Koyanagi‐Harada (VKH) syndrome is a systemic condition characterized by ocular inflammatory disease as well as skin, ear, and meningeal manifestations. Patients with VKH often report tinnitus and hearing loss, but these symptoms tend to be given secondary consideration because most undergo treatment with steroids to prevent blindness resulting from granulomatous uveitis, exudative retinal detachment, and optic nerve inflammation. Methods/Study Design: In the current retrospective review, 24 patients with this syndrome were screened for auditory system abnormalities. All patients denied history of noise exposure or ototoxic agent exposure. The age range of the patients was 13 to 42 years. Results: Three patients reported tinnitus and two patients reported sudden hearing loss. One patient experienced vertigo and aural fullness. Eight of 24 patients had pure‐tone thresholds greater than 25 dB hearing loss at two or more frequencies. Five of 24 of these patients experienced hearing loss outside of the 95% confidence interval for published age‐matched control populations. There was sloping sensorineural hearing loss at 4 kHz and above in five of 24 patients. All eight patients with hearing loss experienced some degree of hearing loss at 4 kHz or above. Three patients had mild to moderate low‐frequency sensorineural hearing loss. There were no tympanometric abnormalities suggestive of conductive involvement. Abnormal acoustic reflex decay was observed in one patient. Conclusions: We conclude that a significant number of patients with VKH experience sensorineural hearing loss and that every patient with VKH should undergo a review of systems for auditory abnormalities and referral for audiologic testing if symptomatic. It is possible that untreated patients may experience worse symptoms.
    Type of Medium: Online Resource
    ISSN: 0023-852X , 1531-4995
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 2026089-1
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  • 9
    Online Resource
    Online Resource
    Elsevier BV ; 2005
    In:  Cancer Detection and Prevention Vol. 29, No. 1 ( 2005-1), p. 42-45
    In: Cancer Detection and Prevention, Elsevier BV, Vol. 29, No. 1 ( 2005-1), p. 42-45
    Type of Medium: Online Resource
    ISSN: 0361-090X
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2005
    detail.hit.zdb_id: 2004189-5
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  • 10
    In: Oral Oncology, Elsevier BV, Vol. 42, No. 10 ( 2006-11), p. 994-1004
    Type of Medium: Online Resource
    ISSN: 1368-8375
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2006
    detail.hit.zdb_id: 2011971-9
    detail.hit.zdb_id: 2202218-1
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