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  • 1
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 62, No. 9 ( 2014-09), p. 619-631
    Abstract: The mechanism by which neuropilin-1 (NRP-1) induces malignancy in Epithelial Ovarian Cancer (EOC) is still unknown. This study is the first to demonstrate the relationship between NRP-1 expression and EMT markers vimentin, N-cadherin, E-cadherin and Slug. We used tissue microarrays containing the three main subtypes of EOC tumors: serous, mucinous cystadenocarcinoma and endometrioid adenocarcinoma and representative cases retrieved from our pathology archives. Immunohistochemistry was performed to detect the expression levels and location of NRP-1 and the aforementioned EMT proteins. NRP-1 was mainly expressed on cancer cells but not in normal ovarian surface epithelium (OSE). The Immunoreactive Scoring (IRS) values revealed that the expression of NRP-1, Slug and E-cadherin in the malignant subtypes of ovarian tissues was significantly higher (5.18 ± 0.64, 4.84 ± 0.7, 4.98 ± 0.68, respectively) than their expression in the normal and benign tissues (1.04 ± 0.29, 0.84 ± 0.68, 1.71 ± 0.66, respectively), with no significant differences among the studied subtypes. Vimentin was expressed in the cancer cell component of 43% of tumors and it was exclusively localized in the stroma of all mucinous tumors. The Spearman’s rho value indicated that NRP-1 is positively related to the EMT markers E-cadherin and Slug. This notion might indicate that NRP-1 is a partner in the EMT process in EOC tumors.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 1421306-0
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Thomas Telford Ltd. ; 2023
    In:  Journal of Environmental Engineering and Science
    In: Journal of Environmental Engineering and Science, Thomas Telford Ltd.
    Abstract: Droughts have become more severe and prolonged in recent years, causing significant social and environmental impacts. Analyzing the drought conditions with various climatic and socioeconomic factors is critical for effective drought monitoring. This study investigated the correlation between drought severity and climatic and socioeconomic changes in a study area – San Diego County, California. The drought severity was quantified using three drought indices: Standardized Precipitation Index (SPI), Standardized Precipitation Evapotranspiration Index (SPEI), and Standardized Streamflow Index (SSI). These indices were also used to describe the variation of the drought severity in the study area. The study employed Spearman’s correlation coefficient analysis to evaluate the correlations between the drought indices and climatic and socioeconomic factors. The results showed that the drought indices evaluated similar variations of the droughts in the study area; however, the severity, duration, and frequency of the droughts varied with the time scales in the drought index analysis. Additionally, this study found that the drought conditions based on the three indices had strong negative correlations with precipitation, soil moisture, agricultural area, and forest area, which were more pronounced as the time scale increased. The findings will provide insights into effective drought monitoring and management, especially targeting severe droughts.
    Type of Medium: Online Resource
    ISSN: 1496-2551 , 1496-256X
    Language: English
    Publisher: Thomas Telford Ltd.
    Publication Date: 2023
    detail.hit.zdb_id: 2074025-6
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  • 3
    In: Nature, Springer Science and Business Media LLC, Vol. 600, No. 7889 ( 2021-12-16), p. 472-477
    Abstract: The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases 3–7 . They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease.
    Type of Medium: Online Resource
    ISSN: 0028-0836 , 1476-4687
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    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 120714-3
    detail.hit.zdb_id: 1413423-8
    SSG: 11
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  • 4
    In: Viruses, MDPI AG, Vol. 11, No. 10 ( 2019-10-14), p. 944-
    Abstract: Canine distemper virus (CDV) and phocine distemper (PDV) are closely-related members of the Paramyxoviridae family, genus morbillivirus, in the order Mononegavirales. CDV has a broad host range among carnivores. PDV is thought to be derived from CDV through contact between terrestrial carnivores and seals. PDV has caused extensive mortality in Atlantic seals and other marine mammals, and more recently has spread to the North Pacific Ocean. CDV also infects marine carnivores, and there is evidence of morbillivirus infection of seals and other species in Antarctica. Recently, CDV has spread to felines and other wildlife species in the Serengeti and South Africa. Some CDV vaccines may also have caused wildlife disease. Changes in the virus haemagglutinin (H) protein, particularly the signaling lymphocyte activation molecule (SLAM) receptor binding site, correlate with adaptation to non-canine hosts. Differences in the phosphoprotein (P) gene sequences between disease and non-disease causing CDV strains may relate to pathogenicity in domestic dogs and wildlife. Of most concern are reports of CDV infection and disease in non-human primates raising the possibility of zoonosis. In this article we review the global occurrence of CDV and PDV, and present both historical and genetic information relating to these viruses crossing species barriers.
    Type of Medium: Online Resource
    ISSN: 1999-4915
    Language: English
    Publisher: MDPI AG
    Publication Date: 2019
    detail.hit.zdb_id: 2516098-9
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  • 5
    In: Journal of Information Technology Education: Research, Informing Science Institute, Vol. 19 ( 2020), p. 953-975
    Abstract: Aim/Purpose: The main objective of this study is to explore students’ beliefs with regard to social media use (SMU) in higher education and the consequences of such use on the perception of their academic performance. Additionally, the study aims to determine the major influential factors with regard to SMU in student learning settings as a means of enhancing their performance. To achieve these objectives, drawing on the literature related to SMU in higher education settings, a research model has been developed. Background: Social media platforms have led to a significant transformation with regard to the communication landscape in higher education in terms of offering enhanced learning and improved teaching experience. Nevertheless, little is known, particularly in developing countries such as Jordan, as to whether or not the use of such platforms by students in higher education increases the perceptions of their academic performance. Therefore, this study has developed a model to examine the perceptions of higher education students with regard to social media use and its effect on their performance. Methodology: The Structural Equation Modelling approach is used to analyze data collected via an online survey in the form of a questionnaire to examine the use of such a model. The study sample is drawn from undergraduate and postgraduate students from three universities (one public and two private) in Jordan. Convenience sampling is used to collect data. Out of 730 sent questionnaire, 513 responses were received, of which 403 were deemed qualified to be part of the data analysis process. Contribution: This study contributes to the literature on social media in higher education by enhancing our understanding of the perceptions of higher education students on the use of social media in their learning. The tested model can be used as a benchmark for other studies that target the impact of social media on student performance in higher education. Findings: The results reveal that perceptions of (1) usefulness, collaborative learning, enhanced communication, enjoyment, and ease of use of social media have a positive effect on the use of such media in student learning; (2) resource sharing has an insignificant effect on social media use in student learning, and (3) social media use has a positive influence on students’ perceptions of their academic performance. Recommendations for Practitioners: Senior management and policy makers in higher education institutions will have to train faculty members on effective strategies and methods in order to effectively integrate social media into education. This would equip faculty members with the necessary digital skills needed to help them to be fully informed regarding the benefits of social media and its tools in learning and teaching activities and would also allow them to avoid any possible drawbacks. Furthermore, faculty members should reconsider their current techniques and strategies, and adopt new methods in their teaching that encourage students to use social media platforms as part of their learning. For example, they can regularly post discussions and assignments on social media platforms to inculcate the habit of using such platforms among students for educational purposes. Students, on the other hand, should be aware of the implications and potential advantageous aspects of SMU in their learning. This could be done by conducting regular workshops and seminars in the various faculties and schools at universities. Recommendation for Researchers: Researchers are encouraged to investigate additional factors that might influence the use of social media by students as well as faculty members. Specially, an emphasis should be given to identify any potential obstacles that might hinder the use of social media in higher education. Impact on Society: Social media is not only useful for socializing, but also it can be an effective educational tool that enhance students’ performance in higher education. Future Research: Although the collected data support the research model, this study is subjected to various limitations that need to be tackled by further studies. This study is based on the principles of quantitative research design. Data for this study was collected via survey questionnaires. Accordingly, future studies may consider a qualitative research design in order to uncover additional factors that may impact the use of social media on the part of higher education students. This would allow researchers to generate in-depth insights and a holistic understanding of SMU by higher education students. A convenience sampling method was employed to select respondents for this study. The respondents who participated in this study were from three universities (one public and two private) in Jordan. Accordingly, future research is deemed to be necessary to achieve a degree of generalizability regarding the findings of this study.
    Type of Medium: Online Resource
    ISSN: 1547-9714 , 1539-3585
    Language: English
    Publisher: Informing Science Institute
    Publication Date: 2020
    detail.hit.zdb_id: 2133325-7
    detail.hit.zdb_id: 2725356-9
    SSG: 5,3
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  • 6
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2021
    In:  Medicinal Chemistry Research Vol. 30, No. 9 ( 2021-09), p. 1614-1634
    In: Medicinal Chemistry Research, Springer Science and Business Media LLC, Vol. 30, No. 9 ( 2021-09), p. 1614-1634
    Type of Medium: Online Resource
    ISSN: 1054-2523 , 1554-8120
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2191978-1
    SSG: 15,3
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  • 7
    In: International Journal of Pharmaceutical and Bio-Medical Science, Everant Journals, Vol. 03, No. 06 ( 2023-05-16), p. 245-278
    Abstract: Background: Antibiotics are potent medication that can stop or significantly limit bacterial development. Misuse of antibiotics is a big issue around the world. Antibiotic resistance has become a major worldwide health concern since it is linked to more cases of illness and death, higher healthcare costs, and longer hospital stays. Numerous studies on antibiotic awareness have demonstrated cultural, behavioral, educational, and healthcare system differences in students' perspectives on antibiotics. The purpose of this pilot study was to assess medical students' perspectives, familiarity, and understanding of antibiotics at two Saudi Arabian universities. Aim: Examine medical students' understanding and perspective on the proper use of antibiotics. The purpose of this survey is to assess the level of knowledge regarding antibiotic resistance among medical students and to provide suggestions for reducing this problem. Methods: Students in the College of Medicine at Alfaisal University and Majmaah University were surveyed using a pre-designed, self-administered questionnaire for this study. A panel of specialists in the field has reviewed the questionnaire. The study's success will depend on the opinions of three distinct cohorts of future doctors. Results: The poll revealed a higher level of knowledge at Majmaah University (74.3%), but at Alfaisal University (71.81%) it was lower. Majmaah University had a higher rate of knowledge acquisition, according to the research. In addition, the study revealed that the rate of awareness at Al Faisal University was (86.35%), whereas the rate of awareness at Majmaah University was (87.13%), and the rate of attitude at Alfaisal University was (86.23%). Moreover, we discovered that as students’ progress in their education, so do their levels of knowledge, attitude, and awareness. Conclusion: The foundation of a thriving society is the use of sound scientific methods. Effective education, from this vantage point, plays a crucial role in imparting knowledge, awareness, and attitude that leads to change in behavior and habits, and therefore in the level of outputs that feed the community with a comprehensive health strategy.
    Type of Medium: Online Resource
    ISSN: 2767-827X , 2767-830X
    Uniform Title: Medical Students' Understanding, Attitudes, and Awareness of Antibiotic Resistance
    Language: Unknown
    Publisher: Everant Journals
    Publication Date: 2023
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  • 8
    In: Archiv der Pharmazie, Wiley, Vol. 354, No. 9 ( 2021-09)
    Abstract: Sphingosine kinase 1 (SphK1) has emerged as an attractive drug target for different diseases. Recently, discovered SphK1 inhibitors have been recommended in cancer therapeutics; however, selectivity and potency are great challenges. In this study, a novel series of benzimidazoles was synthesized and evaluated as SphK1 inhibitors. Our design strategy is twofold: It aimed first to study the effect of replacing the 5‐position of the benzimidazole ring with a polar carboxylic acid group on the SphK1‐inhibitory activity and cytotoxicity. Our second aim was to optimize the structures of the benzimidazoles through the elongation of the chain. The enzyme inhibition potentials against all the synthesized compounds toward SphK1 were evaluated, and the results revealed that most of the studied compounds inhibited SphK1 effectively. The binding affinity of the benzimidazole derivatives toward SphK1 was measured by fluorescence binding and molecular docking. Compounds 33 , 37 , 39 , 41 , 42 , 43 , and 45 showed an appreciable binding affinity. Therefore, the SphK1‐inhibitory potentials of compounds 33 , 37 , 39 , 41 , 42 , 43 , and 45 were studied and IC 50 values were determined, to reveal high potency. The study showed that these compounds inhibited SphK1 with effective IC 50 values. Among the studied compounds, compound 41 was the most effective one with the lowest IC 50 value and a high cytotoxicity on a wide spectrum of cell lines. Molecular docking revealed that most of these compounds fit well into the ATP‐binding site of SphK1 and form hydrogen bond interactions with catalytically important residues. Overall, the findings suggest the therapeutic potential of benzimidazoles in the clinical management of SphK1‐associated diseases.
    Type of Medium: Online Resource
    ISSN: 0365-6233 , 1521-4184
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1496815-0
    SSG: 15,3
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  • 9
  • 10
    In: International Journal of Environmental Research and Public Health, MDPI AG, Vol. 19, No. 24 ( 2022-12-16), p. 16910-
    Abstract: Background: This study aimed to evaluate the midline mandibular lingual canals and foramina and their anatomic variations using CBCT scans. Methods: This study used retrospective analysis. A total of 320 CBCT scans were used to evaluate the study parameters, which comprised the presence or absence of the mandibular lingual foramen (MLF)/mandibular lingual canal (MLC) and its category, the distance between the buccal cortex and the start of the MLC, the distance between the inferior border of the mandible and the superior border of the foramen at its lingual and buccal terminals. The length and diameter of each canal at its lingual and buccal terminals. Results: MLC was found in all included CBCT scans. Out of 320 included CBCT scans, a single canal was represented by 30.9%, double canals (Supra with Infra -spinosum) configuration appeared in 54.7%, and triple canals (Supra-Inter-Infra) represented 14.7%. The supraspinosum canals averaged 5.81 ± 2.08 mm in length and 0.87 ± 0.30 mm in diameter at the lingual terminal. In terms of the number of canals, there was a significant difference between men and women (p ≤ 0.001), with 60% of the men in the sample having double canals and 43.1% of the women having single canals. Moreover, the male gender had a higher prevalence of triple canals (21.3% vs. 8.1%) than females. Males and females were distributed equally among the supraspinosum canals, with no statistically significant difference (p ≤ 0.7). A considerable increase in the finding of interspinosum and infraspinosum canals was seen in the male sample (p ≤ 0.001). Conclusions: midline mandibular canals were found in all investigated CBCTs of the sample of both sexes; however, the anatomy and location of the MLF and canals varied significantly among the Saudi population.
    Type of Medium: Online Resource
    ISSN: 1660-4601
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2175195-X
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