In:
Geriatrics & Gerontology International, Wiley, Vol. 22, No. 9 ( 2022-09), p. 715-722
Abstract:
To investigate the association between medication use and long‐term all‐cause mortality in a Brazilian stroke cohort. Methods Both ischemic and hemorrhagic stroke were evaluated. Medication use was assessed as: never, only pre‐stroke, only post‐stroke, and continuous use. We evaluated anti‐hypertensives, anti‐diabetics, lipid‐lowering drugs, anti‐platelets, and anti‐coagulants. Cox regression models were adjusted for sociodemographic and cardiovascular risk factors. Results Among 1173 incident stroke cases (median age: 68; 86.8% were ischemic, 70% first‐ever stroke), medication use was low (overall: 17.5% pre‐stroke, 26.4% post‐stroke, and 40% were under continuous use). Anti‐hypertensives and anti‐platelets (aspirin) were the continuous cardiovascular medications used most often, at 83.5% and 72%, respectively, while statins (39.7%) and anti‐diabetics (31.3%) were the least used. Medication use (pre‐stroke, post‐stroke and continuous use) was associated with a reduction in all‐cause mortality risk, particularly among those under continuous use (multivariable hazard ratio, 0.52; 95% confidence interval (CI), 0.46–0.66) compared with never‐users. Among ischemic stroke patients, this effect was similar (multivariable hazard ratio, 0.52; 95% CI, 0.40–0.68). No significant associations were evident among hemorrhagic stroke patients. Conclusions The risk of all‐cause mortality was reduced by 48% among those with ischemic stroke under continuous use of medications. Secondary prevention should be emphasized more strongly in clinical practice. Geriatr Gerontol Int 2022; 22: 715–722 .
Type of Medium:
Online Resource
ISSN:
1444-1586
,
1447-0594
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2078308-5
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