In:
Journal of Crohn's and Colitis, Oxford University Press (OUP), Vol. 15, No. 11 ( 2021-11-08), p. 1824-1836
Abstract:
Inflammatory bowel disease [IBD] is linked to psychiatric morbidity, but few studies have assessed general population comparators. We aimed to investigate the risk of psychiatric morbidity and suicide in adult-onset IBD patients. Methods We used a nationwide population-based cohort study in Sweden [1973–2013]. We studied the risk of psychiatric disorders and suicide in 69,865 adult-onset IBD patients [ulcerative colitis, UC: n = 43,557; Crohn’s disease, CD: n = 21,245; and IBD-unclassified: n = 5063] compared to 3,472,913 general population references and 66 292 siblings. Results During a median follow-up of 11 years, we found 7465 [10.7%] first psychiatric disorders in IBD [incidence rate, IR/1000 person-years 8.4] and 306 911 [9.9%] in the general population [IR 6.6] , resulting in 1.8 extra psychiatric morbidity per 100 patients followed-up for 10 years and a hazard ratio [HR] of 1.3 [95% confidence interval, 95%CI = 1.2–1.3] . The highest risk of overall psychiatric morbidity was seen in the first year after IBD diagnosis [HR = 1.4, 95%CI = 1.2–1.6] and in patients with extraintestinal manifestations [HR = 1.6, 95%CI = 1.5–1.7] . Psychiatric morbidity was more common in all IBD subtypes [HR 1.3–1.5]. An increased risk of suicide attempts was observed among all IBD types [HR = 1.2–1.4] , whereas completed suicide was explicitly associated with CD [HR = 1.5] and elderly-onset [diagnosed at the age of & gt; 60 years] IBD [HR = 1.7] . Conclusion Adult-onset IBD was associated with an increased risk of psychiatric disorders and suicide attempts. Psychological follow-up should be provided to patients with IBD, especially those with extraintestinal manifestations and elderly-onset IBD. This follow-up should be within the first year after IBD diagnosis.
Type of Medium:
Online Resource
ISSN:
1873-9946
,
1876-4479
DOI:
10.1093/ecco-jcc/jjab039
Language:
English
Publisher:
Oxford University Press (OUP)
Publication Date:
2021
detail.hit.zdb_id:
2389631-0
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