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  • 1
    Online Resource
    Online Resource
    Association of Circadian Locomotor Output Cycles Kaput Rs1801260 and Hypocretin Receptor 1 Rs2271933 Polymorphisms in Patients with Chronic Migraine and Sleep Disorder
    Medknow ; 2022
    In:  Neurological Sciences and Neurophysiology Vol. 39, No. 2 ( 2022), p. 98-108
    Details
    In: Neurological Sciences and Neurophysiology, Medknow, Vol. 39, No. 2 ( 2022), p. 98-108
    Abstract: Insomnia and excessive daytime sleepiness (EDS) are frequently reported as sleep disorders, especially in patients with chronic migraine (CM). The main drive of conducting a study on the relationship of genes that regulate circadian rhythm is that migraine contains a robust genetic background, and it is known that migraine attacks have circadian characteristics. This study aims to evaluate the relationship of circadian locomotor output cycles kaput (CLOCK) rs1801260 and hypocretin receptor 1 (HCRTR1) rs2271933 gene-related circadian rhythm of patients with CM and sleep disorders. Methods: The present study was designed prospectively in the Mersin University Neurology Clinic. Volunteer individuals aged 18–75 were included in the study in three groups. Each group was made up of 100 individuals. The first group was created among the patients diagnosed with CM. The sleep disorders of patients were evaluated by Epworth Sleep Scale and Pittsburgh Sleep Quality Scale. The second group healthy first-degree relatives of patients. Finally, the third group was formed by the other healthy volunteers who did not have blood relations with the patients. Genotyping was performed for the CLOCK rs1801260 and HCRTR1 rs2271933 genes. Results: Eighty-seven (87%) of the patients, 56 (56%) of the control group 1, and 50 (50%) of the control group 2 consisted of female patients. Their mean ages were 41.1 ± 11.5, 45.7 ± 15.2, and 35.9 ± 10. EDS was detected in 27% of the patients, and poor sleep quality was detected in 67%. About 21% of the patients were found to be suffering from both EDS and poor sleep quality. The CLOCK rs1801260 AG genotype was 6.71 times higher than the AA genotype in the migraine patient group with EDS compared to the second control group (odds ratio [OR]: 6.71, 95% confidence interval [CI] : 0.819–54.992, P = 0.076). The GG genotype, according to the AA genotype, also was found 2.87 times higher in this group (OR = 2.87, 95% CI: 0.336–24.566, P = 0.335). In the group of patients with CM and insomnia, the CLOCK rs1801260 AG genotype was 17.763 times higher than the AA genotype compared to the second control (OR = 17.763, 95% CI: 2.242–140.740, P = 0.006). Conclusion: When CM patients were compared with control groups, CLOCK rs1801260 gene AG genotype was associated with both insomnia and EDS. However, there was no significant relationship between patients and control groups regarding the HCRTR1 rs2271933 gene.
    Type of Medium: Online Resource
    ISSN: 2636-865X
    URL: Article
    DOI: 10.4103/nsn.nsn_195_21
    Language: English
    Publisher: Medknow
    Publication Date: 2022
    detail.hit.zdb_id: 3043067-7
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  • 2
    Online Resource
    Online Resource
    Gender differences in older adults with chronic migraine in T urkey
    Wiley ; 2015
    In:  Geriatrics & Gerontology International Vol. 15, No. 5 ( 2015-05), p. 652-658
    Details
    In: Geriatrics & Gerontology International, Wiley, Vol. 15, No. 5 ( 2015-05), p. 652-658
    Abstract: Chronic migraine is a growing and disabling subtype of migraine with different risk factors and clinical features, even in older adults. We sought to define and differentiate clinical features of chronic migraine in older adults. We also aimed to compare major clinical features of chronic migraine in older adults with those in younger people of both sexes. Methods We used electronic dataset ( T urkish Headache Database) from 13 tertiary headache centers in T urkey. Electronic dataset included detailed headache‐defining features according to ICHD‐II criteria based on face‐to‐face interviews and examination by a headache specialist. Using statistical methods, clinical variables of chronic migraine in older adults were compared with those of younger adults. We included 915 patients with chronic migraine (mean age 43.80 ± 13.95 years); 83.3% were females. In total, 301 patients (32.9%) with chronic migraine aged 〉 50 years were compared with 614 patients aged 〈 50 years. Results There was no significant change in men with increasing age. However, duration of headache history, severity of attacks, previous histories of motion sickness and positive family history of headaches were significantly different in women with increasing age. Further sex‐related differences have been shown in parameters such as attack duration, quality and associated nausea. Conclusion Chronic migraine is an infrequent type of migraine and shows age‐related changes in some phenotypic characteristics, such as severity of attacks, especially in women aged older than 50 years. Furthermore, positive family history of headaches and history of motion sickness increase the likelihood of developing chronic migraine in older women, indicating involvement of some gender‐related, but as‐yet unknown, genetic factors. Geriatr Gerontol Int 2015; 15: 652–658.
    Type of Medium: Online Resource
    ISSN: 1444-1586 , 1447-0594
    URL: Issue
    URL: Article
    DOI: 10.1111/ggi.2015.15.issue-5
    DOI: 10.1111/ggi.12314
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2078308-5
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  • 3
    Online Resource
    Online Resource
    Uncovering clinical and radiological asymmetry in progressive supranuclear palsy—Richardson’s syndrome
    Springer Science and Business Media LLC ; 2022
    In:  Neurological Sciences Vol. 43, No. 6 ( 2022-06), p. 3677-3682
    Details
    In: Neurological Sciences, Springer Science and Business Media LLC, Vol. 43, No. 6 ( 2022-06), p. 3677-3682
    Abstract: Richardson’s syndrome (RS) is considered the most symmetric phenotype of progressive supranuclear palsy (PSP) as opposed to PSP with predominant corticobasal syndrome (PSP-CBS) or parkinsonism (PSP-P). Objectives Evaluate asymmetrical motor and higher cortical features in probable PSP-RS and compare the degree of asymmetry of cortical lobes and hemispheres between PSP-RS, PSP-CBS, PSP-P, and age-matched healthy controls (HC). Methods Asymmetry of motor and higher cortical features evaluated with an extensive videotaped neurologic examination was investigated in 28 PSP-RS, 8 PSP-CBS, and 14 PSP-P. Brain MRI to compute the laterality index (LI) was performed in 36 patients as well as in 56 HC. Results In PSP-RS, parkinsonism was the most common asymmetric motor feature (53.6%), followed by dystonia and myoclonus (21.4% and 17.9%, respectively). Among higher cortical features, limb apraxia was found asymmetric in about one-third of patients. PSP-RS disclosed higher LI for hemispheres compared to HC, indicating a greater degree of asymmetry ( p  = 0.003). The degree of asymmetry of clinical features was not different between PSP-RS and those qualifying for PSP-CBS or PSP-P. As for imaging, LI was not different between PSP-RS, PSP-CBS, and PSP-P in any cortical region. Conclusions Motor and higher cortical features are asymmetric in up to 50% of PSP-RS who also present a greater degree of asymmetry in hemispheres compared to age-matched HC. Lateralization of clinical features should be annotated in PSP.
    Type of Medium: Online Resource
    ISSN: 1590-1874 , 1590-3478
    URL: Article
    DOI: 10.1007/s10072-022-05919-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 1481772-X
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  • 4
    Online Resource
    Online Resource
    What is the contribution of non-pharmacological procedures on the management of chronic migraine?
    Medknow ; 2018
    In:  Neurological Sciences and Neurophysiology Vol. 35, No. 2 ( 2018-06-29), p. 60-69
    Details
    In: Neurological Sciences and Neurophysiology, Medknow, Vol. 35, No. 2 ( 2018-06-29), p. 60-69
    Type of Medium: Online Resource
    ISSN: 2636-865X
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.5152/NSN.2018
    DOI: 10.5152/NSN.
    DOI: 10.5152/NSN.2018.11031
    Language: Unknown
    Publisher: Medknow
    Publication Date: 2018
    detail.hit.zdb_id: 3043067-7
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  • 5
    Online Resource
    Online Resource
    Gray Zones in the Trigeminal Autonomic Cephalalgias
    Medknow ; 2023
    In:  Neurological Sciences and Neurophysiology Vol. 40, No. 1 ( 2023), p. 15-19
    Details
    In: Neurological Sciences and Neurophysiology, Medknow, Vol. 40, No. 1 ( 2023), p. 15-19
    Abstract: Limited data are available about the importance of migrainous features of the trigeminal autonomic cephalalgias (TACs). Methods: We enrolled 99 patients with TACs including 71 cluster headaches, 11 with short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing, 10 with paroxysmal hemicrania, and seven with hemicrania continua. The presence of diagnostic migraine criteria such as throbbing headache, nausea and/or vomiting, photophobia, phonophobia, and aggravation by physical activity was questioned in these patients as well as autonomic features. Furthermore, supportive features of migraine including motion sickness, atopy and allergy, exacerbation during menstrual periods, irregular sleep, dizziness, and family history of any primary headache were noted. Results: The most common cranial autonomic symptom was lacrimation (87.9%) and the most common migrainous features were throbbing headache (51.5%), phonophobia (41.4%), nausea (39.4%), and photophobia (34.3%). Family history of any primary headache (25.3%) and atopy and allergy (13.1%) was the most common supportive features. Conclusion: We found higher percentages of migrainous features in patients with TACs; phonophobia, throbbing headache, and nausea frequently accompanied TACs. Aggravation by physical activity, which is one of the diagnostic migraine criteria, and motion sickness, which is one of the supportive features of migraine, were much lower in patients with TAC compared with migraineurs.
    Type of Medium: Online Resource
    ISSN: 2636-865X
    URL: Article
    DOI: 10.4103/nsn.nsn_108_22
    Language: English
    Publisher: Medknow
    Publication Date: 2023
    detail.hit.zdb_id: 3043067-7
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  • 6
    Online Resource
    Online Resource
    Alzheimer’s disease and Parkinson’s disease dementia: Practical tips for physicians
    AccScience Publishing ; 2023
    In:  Brain & Heart Vol. 2, No. 1 ( 2023-11-28), p. 1712-
    Details
    In: Brain & Heart, AccScience Publishing, Vol. 2, No. 1 ( 2023-11-28), p. 1712-
    Abstract: Dementia is a progressive disorder that weakens the intellectual abilities and causes the cognitive, behavioral, and functional decline in occupational and social areas. This research is targeted to extract a profile for the dementia diagnostic and clinical characteristics by evaluating the near-term effects of Alzheimer & rsquo;s disease (AD) and Parkinson & rsquo;s disease dementia (PD-D). A total of 240 individuals, including 60 AD patients, 60 PD-D patients, and 120 healthy controls, were included in the study. Data of individuals treated in a local dementia outpatient clinic between 2013 and 2023 were obtained from the clinic database. AD and PD-D diagnoses were made based on the revised National Institute on Aging and Alzheimer & rsquo;s Association (NIA-AA) criteria and movement disorder society (MDS) clinical diagnostic criteria, respectively. Functional, clinical, and neuropsychological evaluations of the patients were made by the same neurologist. Dementia staging and daily living activities were determined and categorized. In the patient group, functionality and instrumental activities of daily living (ADLs) scores were significantly worse than those of the control group, but there was no difference between the AD and PD-D groups. Calculation, verbal fluency, word list, early learning, and clock drawing test scores were lower in the AD group than in the PD-D group. Apathy, disinhibition, elution, irritability, abnormal motor movements, sleep, and appetite scores were significantly higher in the patient group than in the control group. While depression parameters were not significantly different between all the groups, hallucinations and anxiety parameters were significantly higher in the PD-D group than in the AD group. As an important predictor of independent living and the burden of disease, functional impairment is an important issue in patients with AD compared to those with PD-D. This study also highlights the neuropsychiatric perception disorder in terms of functional loss in AD and significant anxiety disorder for PD-D accompanied by early functional losses.
    Type of Medium: Online Resource
    ISSN: 2972-4139
    URL: Article
    DOI: 10.36922/bh.1712
    Language: Unknown
    Publisher: AccScience Publishing
    Publication Date: 2023
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