In:
Communications Biology, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2023-04-21)
Abstract:
Skeletal muscle is sensitive to gravitational alterations. We recently developed a multiple artificial-gravity research system (MARS), which can generate gravity ranging from microgravity to Earth gravity (1 g ) in space. Using the MARS, we studied the effects of three different gravitational levels (microgravity, lunar gravity [1/6 g ], and 1 g ) on the skeletal muscle mass and myofiber constitution in mice. All mice survived and returned to Earth, and skeletal muscle was collected two days after landing. We observed that microgravity-induced soleus muscle atrophy was prevented by lunar gravity. However, lunar gravity failed to prevent the slow-to-fast myofiber transition in the soleus muscle in space. These results suggest that lunar gravity is enough to maintain proteostasis, but a greater gravitational force is required to prevent the myofiber type transition. Our study proposes that different gravitational thresholds may be required for skeletal muscle adaptation.
Type of Medium:
Online Resource
ISSN:
2399-3642
DOI:
10.1038/s42003-023-04769-3
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2023
detail.hit.zdb_id:
2919698-X
Permalink