In:
Digestion, S. Karger AG, Vol. 90, No. 1 ( 2014), p. 1-9
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 We investigated the association between long-segment Barrett's esophagus and obesity in the Japanese population in a multicenter case-control trial. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 One hundred thirteen patients with endoscopically detected Barrett's esophagus with a length of more than 2 cm and the same number of sex- and age-matched controls were prospectively enrolled. Barrett's esophagus was diagnosed based on the Prague C and M criteria. The body mass index (BMI) of the subjects was categorized into the following groups: normal, BMI 〈 22.9; overweight, BMI 23.0-24.9, and obese, BMI 〉 25.0. To determine the association between BMI and the risk of Barrett's esophagus, multivariate logistic regression analyses were performed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The basically adjusted regression model adjusted for smoking and alcohol consumption revealed that overweight and obesity were significantly associated with an elevated risk of Barrett's esophagus (OR 2.4, 95% CI 1.2-4.7, and OR 2.5, 95% CI 1.3-4.6, respectively). The intensity of the association was not attenuated even after adjustment for gastroesophageal reflux disease-related parameters. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 An increased BMI was associated with an increased risk for Barrett's esophagus through a gastroesophageal reflux-independent mechanism in the Japanese population. Further, unlike in Caucasian populations, being even slightly overweight with a BMI of 23.0-24.9 was an independent risk factor in the Japanese population.
Type of Medium:
Online Resource
ISSN:
0012-2823
,
1421-9867
Language:
English
Publisher:
S. Karger AG
Publication Date:
2014
detail.hit.zdb_id:
1482218-0
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