In:
International Journal of Cancer, Wiley, Vol. 140, No. 2 ( 2017-01-15), p. 370-380
Abstract:
What's new? It is essential to focus cancer immunotherapies on tumor antigens that are specifically expressed in the tumor and in many patients. Immune complexes (ICs), which are the direct and stable products of immunological recognition by humoral immunity, may help achieve this. Here, the authors separated ICs from serum and subjected them to direct tryptic digestion and nano‐liquid chromatography‐tandem mass spectrometry to comprehensively identify and profile the constituent antigens in ICs. In the pilot study, gelsolin and inter‐alpha‐trypsin inhibitor heavy chains were specifically and frequently ( 〉 80%) detected in the ICs of lung cancer patients, with phosphoproteins also being specifically expressed.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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